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Blood brain barrier pharmacokinefic continuous dosing system and detecting system

A blood-brain barrier and detection system technology, applied in the field of medical detection systems, can solve problems such as difficulty in passing through, and achieve the effects of being easy to popularize and use, simple to manufacture, and convenient to manufacture.

Inactive Publication Date: 2012-11-21
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It is very difficult to evaluate the passage of drugs through the blood-brain barrier and the degree of passage. The existing detection methods have their advantages and disadvantages, and different drugs often show different drug distributions. Therefore, there is no one of the existing detection methods The method can be applied to all drug distribution evaluations. Therefore, it is urgently needed in the current pharmaceutical research and development process to develop a wide-ranging, efficient, and easy-to-operate technical method that passes through the blood-brain barrier. The development of therapeutic drugs is of great significance

Method used

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  • Blood brain barrier pharmacokinefic continuous dosing system and detecting system
  • Blood brain barrier pharmacokinefic continuous dosing system and detecting system
  • Blood brain barrier pharmacokinefic continuous dosing system and detecting system

Examples

Experimental program
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Effect test

Embodiment 1

[0066] Embodiment 1 Blood-brain barrier dynamics detection system shown in the present invention

[0067] Figures 1 to 6 It shows a best preferred mode of the blood-brain barrier dynamics detection system in the awake state of the present invention.

[0068] Such as figure 1 As shown, a blood-brain barrier pharmacokinetic continuous drug delivery system for experimental animals established in the present invention includes a drug delivery part, a connecting part and a fixing part. The administration part includes a heparin cap 1 , a screw 2 , a rigid catheter 3 , an injection inner tube 5 and a screw cap 6 . The heparin cap 1 is connected to the end of the vertical part of the rigid catheter, which can prevent liquid leakage and air embolism. The upper end of the screw 2 can be tightened with the heparin cap 1, and the lower end can be tightened with the nut 6, so as to fix the connection between the injection inner tube and the hard catheter. The rigid catheter 3 is bent...

Embodiment 2

[0086] Example 2 Using the detection system shown in the present invention to study the situation of heparin passing through the blood-brain barrier in rats

[0087] 1. Administering drugs through intravenous continuous drug delivery system

[0088] ① 10% chloral hydrate 0.3ml / 100g urethane (1.2g / kg) anesthetized rats, fixed in supine position; sealed eyes with chlortetracycline eye ointment, in front of front teeth - right armpit and right ear - left armpit The intersection area of ​​the lines defines the first surgical area and performs the first skin preparation, disinfects the first surgical area, lays a perforated surgical drape, cuts a longitudinal skin incision in the first surgical area, about 1-1.5cm, cuts For deep and superficial fascia under the skin, hemostasis was performed in time, the subcutaneous tissue and muscle tissue were bluntly separated along the muscle space along the fiber direction, the right jugular vein was exposed and freed, and a thread was ligate...

Embodiment 3

[0103] Example 3 Using the detection system shown in the present invention to study corn oligopeptides and wheat oligopeptides passing through the blood-brain barrier of rats

[0104] The experimental operation steps and model making are the same as in Example 1, except that the administration is corn oligopeptide and wheat oligopeptide, which are prepared as a 0.01 mg / ml solution, and each mouse is injected with 0.5 ml. The results show that after 20 minutes of administration, The cerebrospinal fluid showed the presence of corn oligopeptides and wheat oligopeptides, and within 20 minutes to 45 minutes, the concentration of corn oligopeptides and wheat oligopeptides in the cerebrospinal fluid was the highest at 40 minutes, suggesting that the drugs can easily pass through the blood-brain barrier.

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Abstract

The invention discloses a detecting system capable of detecting whether drugs permeate through blood brain barrier in real time, and particularly discloses a continuous dosing device and a pharmacokinefic system which continuously extracts cerebrospinal fluid to perform high performance liquid chromatography (HPLC) analysis to detect blood brain barrier in real time under the waking state of an experimental animal. The detecting system overcomes shortcomings of existing monitoring means, is simple in operation and high in sensitivity, and has wide medical application prospects.

Description

technical field [0001] The invention belongs to the field of medical detection systems, and relates to a set of detection systems for real-time detection of drugs passing through the blood-brain barrier, in particular to a blood-brain barrier pharmacokinetic continuous drug delivery system and detection system, especially to a set of detection systems for rats in an awake state A continuous drug delivery device and a pharmacokinetic system that continuously draws cerebrospinal fluid for HPLC analysis to detect the blood-brain barrier in real time. Background technique [0002] The BBB is a structure that maintains the stability of the microenvironment around neurons in the central nervous system, thereby ensuring the normal functional activities of neurons. According to the shape, the BBB can be divided into three categories: blood-brain barrier (BBB), blood-cerebrospinal fluid barrier, and cerebrospinal fluid-brain barrier. Among them, the blood-brain barrier is the most i...

Claims

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Application Information

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IPC IPC(8): A61D7/00A61B10/00
Inventor 顾怀宇徐晔邓盛文邱佳和陈佛平余照亮邱帅
Owner SUN YAT SEN UNIV
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