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PLGA(polylactic-co-glycolic acid)/hydroxyapatite/calcium carbonate compound microspheres and preparation method thereof

A technology of hydroxyapatite and composite microspheres is applied in the field of preparation of biomedical materials, which can solve the problems of unfavorable degradable material application, slow degradation rate of hydroxyapatite, etc., so as to improve bone repair ability, avoid residues, and improve bone quality. The effect of osteoconductivity

Active Publication Date: 2014-05-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of hydroxyapatite is too slow, which is not conducive to the application of degradable materials

Method used

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  • PLGA(polylactic-co-glycolic acid)/hydroxyapatite/calcium carbonate compound microspheres and preparation method thereof
  • PLGA(polylactic-co-glycolic acid)/hydroxyapatite/calcium carbonate compound microspheres and preparation method thereof
  • PLGA(polylactic-co-glycolic acid)/hydroxyapatite/calcium carbonate compound microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 1 g of PLGA and 5 mg of dexamethasone and dissolve them in 20 mL of dichloromethane to obtain 20 mL of PLGA organic solution. Weigh 0.5g of hydroxyapatite and 0.2g of calcium carbonate and add to 20mL PLGA organic solution, and stir at 300rpm and 300w ultrasonic power for 10min to obtain a mixed solution of PLGA / hydroxyapatite / calcium carbonate. Weigh 4g of PVA and add it into 500mL of deionized water, heat to 90°C under stirring to dissolve the PVA, and obtain a PVA aqueous solution after cooling. Weigh 0.6g of gluconolactone and dissolve in PVA aqueous solution to obtain acidic PVA aqueous solution. The PLGA / hydroxyapatite / calcium carbonate mixed solution was added dropwise to the acidic PVA aqueous solution under the stirring condition of 350rpm to obtain an oil-in-water single emulsion. The single emulsion was continuously stirred in a fume hood at 350 rpm for 24 hours to volatilize the dichloromethane in the single emulsion and solidify the oil droplets into...

Embodiment 2

[0037] The difference between this example and Example 1 is that no gluconolactone is added to the PVA aqueous solution. Compared with the microspheres in Example 1, the surface pores of the microspheres in this example are mostly closed structures.

Embodiment 3

[0039] Weigh 1 g of PLGA and dissolve it in 20 mL of dichloromethane to obtain 20 mL of PLGA organic solution. Weigh 0.25g of hydroxyapatite and 0.1g of calcium carbonate into the PLGA organic solution, stir at 300rpm and 300w ultrasonic power for 10min to obtain a mixed solution of PLGA / hydroxyapatite / calcium carbonate. Weigh 1 g of PVA and add it to 500 mL of deionized water, heat to 90° C. under stirring to dissolve the PVA, and obtain a PVA aqueous solution after cooling. Weigh 0.5 g of gluconolactone and dissolve in PVA aqueous solution to obtain acidic PVA aqueous solution. The PLGA / hydroxyapatite / calcium carbonate mixture was added dropwise to the acidic PVA aqueous solution under the stirring condition of 400rpm to obtain an oil-in-water single emulsion. The emulsion was continuously stirred for 20 hours in the fume hood to volatilize the dichloromethane in the dairy industry, and the oil droplets solidified into balls. The obtained microspheres were collected, washe...

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PUM

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Abstract

The invention discloses PLGA / hydroxyapatite / calcium carbonate compound microspheres and a preparation method of the PLGA / hydroxyapatite / calcium carbonate compound microspheres. The preparation method of the compound microspheres comprises the following steps of: (1) adding hydroxyapatite and calcium carbonate into a PLGA inorganic solution to obtain a mixture solution; (2) dissolving glucolactone into a PVA (polyvinyl alcohol) aqueous solution to obtain an acidic PVA aqueous solution; (3) adding the mixture solution obtained in step (1) into the acidic PVA aqueous solution, and forming single emulsion of oil in water; and (4) mixing the single emulsion to volatize dichloromethane, curing emulsion drops to be spheres, collecting the obtained microspheres, washing by de-ionized water, and freezing and drying to obtain the compound microspheres. The microspheres obtained by the method disclosed by the invention are regular in appearance, have controllable and porous surfaces, and do not need any externally-added pore-forming agent. The compound microspheres are better in medicine sustained-release capacity and are beneficial to the growth of the cells on the surfaces.

Description

technical field [0001] The invention relates to a preparation technology of biomedical materials, in particular to a preparation method of PLGA / hydroxyapatite / calcium carbonate composite microspheres with porous surfaces. Background technique [0002] Clinically, larger bone defects require bone graft surgery to repair. Although traditional autologous bone transplantation and allogeneic bone transplantation have certain clinical applications, they both have certain defects, such as very limited sources of autologous bone, and the possibility of allogeneic bone spreading diseases. Therefore, bone defect repair methods based on biomaterial scaffolds have attracted increasing attention. Biomaterial scaffolds can provide a three-dimensional space platform for cell growth and metabolism, which is beneficial for cells to obtain nutrients, perform gas exchange, and discharge metabolic waste. Compared with preformed stents, injectable stents have less trauma and can fill defects o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/54
Inventor 王迎军程德林曹晓东高会场郝丽静
Owner SOUTH CHINA UNIV OF TECH
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