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Chinese medicament for treating atrophic gastritis and preparation method thereof

A technology for atrophic gastritis and drugs, applied in the field of drugs for the treatment of atrophic gastritis, can solve the same problems and achieve the effects of easy acceptance, simple and scientific process, and comprehensive indications

Inactive Publication Date: 2012-11-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chronic atrophic gastritis belongs to the category of "epigastric pain" and "fullness" in traditional Chinese medicine, but it cannot be completely equated with it

Method used

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  • Chinese medicament for treating atrophic gastritis and preparation method thereof
  • Chinese medicament for treating atrophic gastritis and preparation method thereof
  • Chinese medicament for treating atrophic gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Animal experiment example 1: Effect of p-xylene on mouse ear swelling

[0023] Observe the effect of the capsule of the present invention on mouse ear swelling caused by xylene. Test drug powder, batch number: 100101; xylene, domestic analytical grade. Yangwei Granules was selected as the positive control drug, batch number: 090403, from Zhengda Qingchunbao Pharmaceutical Co., Ltd. The experimental animals were Kunming mice, provided by the Experimental Animal Center of Fourth Military Medical University.

[0024] Take 50 mice and divide them into 5 groups randomly, 10 mice in each group, with a body weight of 20±2.5g, give the corresponding dose of medicine once a day, for 6 consecutive days, and drop 0.05ml of xylene in the right ear of each mouse after 1 hour of the last administration. Inflammation, the left ear was used as a control, and the left ear was killed after 15 minutes of inflammation. Both ears were cut off, and round ear pieces were respectively punche...

experiment example 2

[0028] Animal Experiment Example 2: Effects on Pain in Mice

[0029] (1) Hot plate method: 50 mice were randomly divided into 5 groups, 10 in each group, and the dosage was the same as above. One hour after the last administration, the mice were put into a hot beaker (constant temperature water bath 55°C ± 1°C); and timed immediately, and the time (s) required for the mice to lick their hind feet from being put into the beaker was recorded as the Rat pain threshold, and calculate the pain threshold increase rate, the calculation formula is: [(average pain threshold after medication-average pain threshold of unmedicated group) / average pain threshold of unmedicated group]×100%. The results showed that the test drug 0.80g / kg and 0.40g / kg had significant analgesic effect (P<0.01).

[0030] The impact of table 2 on mouse pain (n=10; )

[0031]

[0032] Note: * P<0.01 compared with model group.

[0033] (2) Writhing method: each mouse was given ip 0.5% acetic acid solution ...

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Abstract

The invention provides a Chinese medicament for treating atrophic gastritis and a preparation method thereof, and belongs to the technical field of Chinese medicament preparation. The Chinese medicament is prepared from natural Chinese herbal medicines as raw material prescription, and is characterized by comprising the following natural Chinese herbal medicines in parts by weight: 20 to 40 parts of astragalus mongholicus, 15 to 30 parts of raw rehmannia root, 10 to 20 parts of dwarf lilyturf tuber, 20 to 40 parts of white peony root, 10 to 20 parts of Chinese angelica, 8 to 16 parts of curcuma zedoary, 8 to 16 parts of corydalis tuber, and 3 to 6 parts of goldthread. Studies prove that the Chinese medicament has the functions of tonifying qi and nourishing yin, activating blood circulation to relieve pains, and treating chronic atrophic gastritis. The medicament has certain effects in improving symptoms, strengthening appetite, promoting digestion, relieving pains and the like, has no remarkable adverse response and high safety, is especially suitable for treating middle-aged and aged patients with chronic atrophic gastritis, and is rich in raw material sources and low in production cost, so that the economic burden of the patient can be greatly reduced by taking the medicament.

Description

Technical field [0001] The invention belongs to a medicine for treating atrophic gastritis, in particular to a traditional Chinese medicine preparation composed of Chinese herbal medicine extracts. Background technique [0002] Chronic atrophic gastritis, also known as atrophic gastritis, is one of the common diseases of the digestive system. It refers to the pathological changes in which the mucosal glands atrophy or even disappear after repeated damage to the surface of the gastric mucosa, and the muscularis mucosa often thickens. Due to the atrophy or disappearance of the glands, the gastric mucosa is thinned to varying degrees, often accompanied by intestinal metaplasia, inflammatory reactions and atypical hyperplasia; arteriosclerosis, insufficient gastric blood flow, addiction to tobacco, alcohol and tea, etc. are easily damaged The disease is caused by the barrier function of the gastric mucosa. The clinical manifestations of this disease are loss of appetite, nausea...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/16A61K9/20A61K9/48A61P1/04
Inventor 石小鹏栗艳缪珊张伟吴振宇吴寅冯娟文爱东
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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