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Quality detection method of traditional Chinese medicine composition for treating headache

A quality detection method and composition technology, which are applied in the field of traditional Chinese medicine compositions for treating headache and their preparation, and pharmaceutical compositions, can solve problems such as poor tolerance, and achieve the effect of ensuring safety

Active Publication Date: 2012-10-24
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking these drugs for a long time will not only cause addiction, but also have poor tolerance, which cannot fundamentally solve the patient's headache problem

Method used

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  • Quality detection method of traditional Chinese medicine composition for treating headache
  • Quality detection method of traditional Chinese medicine composition for treating headache
  • Quality detection method of traditional Chinese medicine composition for treating headache

Examples

Experimental program
Comparison scheme
Effect test

experiment example 2

[0090] Experimental example 2 Experimental research on quality detection method

[0091] 1. TLC identification of Rhizoma Chuanxiong

[0092] (1) Preparation of the test solution and the reference solution

[0093] Take 20 tablets of the preparation prepared according to Example 1 in four parts, remove the sugar coating, grind finely, add 30 ml of ether for ultrasonic treatment, filter, evaporate the filtrate to dryness, add 1 ml of ethanol to the residue to dissolve, and use it as the test solution.

[0094] Four parts of 1 g of Chuanxiong reference drug were taken, 30 ml of ethanol was added for ultrasonic treatment, filtered, the filtrate was evaporated to dryness, and the residue was dissolved with 1 ml of ethanol as the reference drug solution.

[0095] According to the preparation method of Example 1, a negative sample lacking Rhizoma Chuanxiong was prepared, and then a negative control solution was prepared according to the preparation method of the test solution.

[...

Embodiment 1

[0207] Horn 1400g, Ligusticum chuanxiong 250g, Angelica dahurica 450g, Aconitum 150g, Uncaria 200g

[0208] Pound slices of croissants, decoct twice with water, add 8 times the amount of water for the first time and cook for 3 hours, add 6 times the amount of water for the second time and cook for 3 hours, filter in several times, combine the filtrates, and concentrate to a thick paste of 1.35 (50°C); the rest of Ligusticum chuanxiong was crushed to 24 meshes, according to the percolation method under the item of liquid extract and extract, using 30% ethanol as solvent, percolating at a speed of 150ml / min*kg, until the liquid was completely dry. until there is no alkaloid reaction, collect the ethanol, concentrate to 1.35 thick paste (50°C), mix with croissant and 100g dextrin, granulate, dry, press into 1000 tablets, and coat with sugar, that is have to.

Embodiment 2

[0210] 1400g croissant, 250g Chuanxiong, 450g Angelica dahurica, 150g Chuanwu

[0211] Pound slices of croissants, decoct twice with water, add 8 times the amount of water for the first time and cook for 3 hours, add 6 times the amount of water for the second time and cook for 3 hours, filter in several times, combine the filtrates, and concentrate to a thick paste of 1.35 (50°C); the rest of Ligusticum chuanxiong was crushed to 24 meshes, according to the percolation method under the item of liquid extract and extract, using 30% ethanol as solvent, percolating at a speed of 150ml / min*kg, until the liquid was completely dry. until there is no alkaloid reaction, collect the percolated liquid, recover ethanol, concentrate to 1.35 thick paste (50°C), mix with croissant and 116g dextrin, granulate, dry, press into 1000 tablets, and coat with sugar, that is have to.

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Abstract

The invention provides a traditional Chinese medicine composition for treating headache and its preparation method and quality control method. The traditional Chinese medicine composition comprises cassia seed, szechuan lovage rhizome, dahurian angelica root, prepared aconite root and gambir plant. The traditional Chinese medicine composition can be added with auxiliary materials and be prepared into clinically acceptable tablets, capsules, an oral liquid, dropping pills, soft capsules and granules by conventional processes. The quality control method of the traditional Chinese medicine composition comprises the following steps of carrying out qualitative detection of szechuan lovage rhizome and dahurian angelica root, carrying out qualitative amount-limited detection of aconitine, carrying out quantitative detection of alcohol soluble extract, carrying out detection of nitrogen content, and carrying out quantitative detection of ferulic acid. The traditional Chinese medicine composition has an obvious effect of treating headache.

Description

[0001] The present invention is a divisional application, the original application number is 200810057967.8, the original application date is February 22, 2008, and the original application name is a traditional Chinese medicine composition for treating headache and its preparation method and quality control method. technical field [0002] The invention relates to a pharmaceutical composition, in particular to a traditional Chinese medicine composition for treating headache, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0003] Headache is a clinically common disease, and currently the main symptoms of headache can be found in infectious febrile diseases, hypertension, intracranial disorders, neurosis, concussion and migraine and other diseases. [0004] Headaches can occur in those who suffer from exogenous six evils, internal injury to viscera, blockage of yang qi, upward...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90A61K36/74A61K36/714A61P25/06A61P25/04A61K35/32
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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