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Blonanserin dispersible tablet and its preparation method

A technology of blonanserin and dispersible tablets, which is applied in the field of antipsychotic drugs and its preparation, and can solve the problems of inconvenient taking of multi-dose blonanserin

Inactive Publication Date: 2012-10-17
北京德众万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to improve the inconvenient problem of taking multiple doses of blonanserin by optimizing the dosage form, improve the dissolution rate of blonanserin and the absorption in the human body, and provide a dispersible tablet containing blonanserin and its preparation method

Method used

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  • Blonanserin dispersible tablet and its preparation method
  • Blonanserin dispersible tablet and its preparation method
  • Blonanserin dispersible tablet and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0025]

[0026] Control the particle size of blonanserin at 3-5 μm through an air jet mill, mix well with lactose, 6 g of croscarmellose sodium, and microcrystalline cellulose PH101, and then add 25 g of hydroxypropyl cellulose Vegetable solution (2%) as a binder, wet granulation, and then dry the granules in a constant temperature drying oven at 50°C until the moisture is less than 5%, add 3g croscarmellose sodium, 1.8g microcrystalline cellulose PH102, add magnesium stearate, micro-powder silica gel, mix well, and press into tablets.

Embodiment 2

[0028]

[0029] Micronize the raw material to 3-5μm, mix with lactose, 15.8g croscarmellose sodium, microcrystalline cellulose PH101, add 50g hydroxypropyl cellulose solution (2%) as a binder, Wet granulation, and then dry the granules in a constant temperature drying oven at 50°C until the water content is less than 5%, add 7.9g croscarmellose sodium, magnesium stearate, micro-powder silica gel, mix well, and press into tablets.

Embodiment 3

[0031] 8 mg blonanserin tablets

[0032]

[0033] Micronize the raw material to 3-5μm, mix with lactose, 24g low-substituted hydroxypropyl cellulose, and microcrystalline cellulose PH101, add 108g hydroxypropyl cellulose solution (2%) as a binder, and wet process Then dry the granules in a constant temperature drying oven at 50°C until the water content is less than 5%, add 12g of low-substituted hydroxypropyl cellulose, magnesium stearate and micro-powder silica gel, mix well, and press into tablets.

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Abstract

The invention discloses a blonanserin-containing dispersible tablet combination and its preparation. The dosage form can be rapidly and uniformly dispersed in water to form a suspension, and absorption of the hard-soluble bulk drug blonanserin can be effectively raised.

Description

technical field [0001] The invention relates to an antipsychotic drug and a preparation method thereof, in particular to a composition and a preparation method of a dispersible tablet containing blonanserin. The dosage form can effectively improve the absorption of blonanserin, and is in a uniform suspension state after disintegrating rapidly in water. Background technique [0002] Schizophrenia (schizophrenia) is a common psychiatric disease, characterized by changes in basic personality, split thinking, emotion, and behavior, and incoordination between mental activities and the environment. 1.0% of the burden, the number of patients in my country has exceeded 8 million, and it is increasing year by year, which has caused a series of social problems such as suicide. [0003] Since the discovery of the antipsychotic effects of chlorpromazine in the early 1950s, schizophrenia has been dominated by drug treatment. Currently commonly used antipsychotic drugs are divided into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/496A61K47/38A61P25/18
Inventor 杨帆郭夏
Owner 北京德众万全医药科技有限公司
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