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Method for extracting synephrine and hesperidin from citrus aurantium

A technology for hesperidin and citrus aurantium is applied in the field of extracting synephrine and hesperidin to achieve the effects of reducing production cost and production process

Active Publication Date: 2012-10-10
SICHUAN XINHUAKANG BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, these extraction methods are either extracting synephrine or extracting hesperidin. There is no process that can obtain synephrine and hesperidin at the same time.

Method used

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  • Method for extracting synephrine and hesperidin from citrus aurantium
  • Method for extracting synephrine and hesperidin from citrus aurantium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) Take 1000kg of citrus aurantium, wash it with tap water, crush it into citrus citrus granules, put it into an extraction tank, add 5000L of 0.08M hydrochloric acid solution and let it soak for 1 hour, then percolate and extract for 6 hours, and collect the extract.

[0034] 2) Concentrating the filtered extract in 1) under reduced pressure to obtain an extract, and the specific gravity of the extract is controlled at 1.1-1.2. The concentration vacuum is controlled at -0.07 ~ -0.08Mpa, and the temperature is below 80°C.

[0035] 3) The extract obtained in 2) is dried under reduced pressure and crushed to obtain a synephrine product.

[0036] 4) Add 4000L of 0.5% sodium bicarbonate solution to the leached citrus aurantium granules extracted by 1) hydrochloric acid solution, heat to boil, keep boiling for 30 minutes, and drain the decoction.

[0037] 5) Add 15,000L of 0.15M sodium hydroxide and 75kg of calcium chloride to the citrus aurantium granules after decocting a...

Embodiment 2

[0042] 1) Take 1000kg of citrus aurantium, wash it with tap water, crush it into citrus citrus granules, put it into an extraction tank, add 7000L of 0.07M hydrochloric acid solution and let it soak for 2 hours, then percolate and extract for 7 hours, and collect the extract.

[0043] 2) Concentrating the filtered extract in 1) under reduced pressure to obtain an extract, and the specific gravity of the extract is controlled at 1.1-1.2. The concentration vacuum is controlled at -0.07 ~ -0.08Mpa, and the temperature is below 80°C.

[0044] 3) Dry the extract obtained in 2) under reduced pressure to obtain synephrine.

[0045] 4) Add 4000L of 0.6% sodium bicarbonate solution to the citrus aurantium grains extracted by 1) hydrochloric acid solution, heat to boil, keep boiling for 30 minutes, and drain the decoction. Decoct three times in the same way (that is, add 4000L of 0.6% sodium bicarbonate solution each time, heat to boil, keep boiling for 30 minutes, and drain the decoct...

Embodiment 3

[0051] 1) Take 1000kg of citrus citrifolia, wash it with tap water, crush it into citrus citrus granules, put it into an extraction tank, add 11000L of 0.06M hydrochloric acid solution and let it soak for 4 hours, then percolate and extract for 7 hours, and collect the extract.

[0052] 2) Concentrating the filtered extract in 1) under reduced pressure to obtain an extract, and the specific gravity of the extract is controlled at 1.1-1.2. The concentration vacuum is controlled at -0.07 ~ -0.08Mpa, and the temperature is below 80°C.

[0053] 3) Dry the extract obtained in 2) under reduced pressure to obtain synephrine.

[0054] 4) Add 4000L of 0.4% sodium bicarbonate solution to the leached citrus aurantium granules extracted by 1) hydrochloric acid solution, heat to boil, keep boiling for 30 minutes, and drain the decoction. Decoct twice in the same way (that is, add 4000L of 0.6% sodium bicarbonate solution each time, heat to boil, keep boiling for 30 minutes, and drain the ...

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Abstract

The invention discloses a method for extracting synephrine and hesperidin from citrus aurantium, and relates to a method for producing and processing traditional Chinese medicine. The method comprises the following steps of: step 1, washing and crushing a citrus aurantium raw material into citrus aurantium granules; adding an acid solution for soaking the citrus aurantium granules, then carrying out percolation and extracting extract, concentrating the extract under the reduced pressure to obtain extractum, and drying the extractum under the reduced pressure to obtain synephrine; step 2, adding a weak base solution into the leached citrus aurantium granules which are extracted after being soaked by the acid solution, carrying out decoction and removing impurities, then adding a mixed solvent of sodium hydroxide and calcium chloride into the citrus aurantium granules, and extracting to obtain extract; step 3, adding hydrochloric acid into the extract for neutralization until the pH value is 3-7, standing still and crystallizating; and step 4, collecting crystalline, and drying to obtain the hesperidin. Compared with the prior art, the method can be used for extracting two components without using an organic solvent, so that the production cost is reduced, the production technology is simplified, the synephrine yield is more than 15%, the content of the synephrine is more than 10%, the hesperidin yield reaches more than 27%, and the content of the hesperidin is more than 96%; and therefore, the method is suitable for industrialized mass production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine production and processing, in particular to a method for extracting synephrine and hesperidin from Citrus aurantium. Background technique [0002] Citrus aurantium is a commonly used traditional Chinese medicine. It is the dried young fruit of Rutaceae plant lime and its cultivars or sweet orange. Synephrine is one of the ingredients in Citrus aurantium, which has the functions of constricting blood vessels, raising blood pressure, expanding trachea and bronchi, anti-shock, improving metabolism, and losing weight. It is a natural stimulant and is used clinically. It is used in the treatment of bronchial asthma, hypotension, collapse and shock during surgery and anesthesia. Hesperidin has the functions of maintaining normal osmotic pressure of blood vessels, reducing the fragility of blood vessels, shortening bleeding time, and preventing arteriosclerosis. It is widely used in medical f...

Claims

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Application Information

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IPC IPC(8): C07C215/60C07C213/10C07H17/07C07H1/08
Inventor 于非夏雯陈华英邓旭
Owner SICHUAN XINHUAKANG BIO TECH
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