Triggerable and disposable microchip liquid pump based on chemical reaction

A chemical reaction and microchip technology, applied in chemical instruments and methods, chemical/physical processes, chemical/physical/physicochemical processes, etc., can solve problems such as uncertainty, analysis results, etc.

Inactive Publication Date: 2014-04-02
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, for chips used for analysis and detection, liquid flow drive often involves quantitative reagent addition, mixing and other processes, but users cannot be required to have the technology of manually quantitatively adding reagents, otherwise it will make the analysis artificial uncertainty

Method used

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  • Triggerable and disposable microchip liquid pump based on chemical reaction
  • Triggerable and disposable microchip liquid pump based on chemical reaction
  • Triggerable and disposable microchip liquid pump based on chemical reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Step 1. Expose the glass chromium plate with a patterned film (the pattern includes the middle pump chamber and the driving U pipeline at the back, refer to 9 and 10 in the accompanying drawing), and then use 1mol / L HF acid solution to Etching for 0.5 hours and 4 hours serves as a template for the upper and lower PDMS sheets.

[0028] Step 2. Mix polydimethylsiloxane (PDMS) and curing agent at a ratio of 5:1, pour it on the glass mold, use a vacuum pump to remove air bubbles, and heat in an oven at 100°C for 0.2 hours to make PDMS Curing, and then peeling off from the mold to make the top and bottom PDMS sheets, punch holes with a puncher at the exit of the top PDMS sheet as the top sheet of PDMS.

[0029] Step 3. Add 0.1 μL of fluorosilane solution dropwise to the middle tank of the solid on the PDMS top sheet, and dry it under an infrared lamp.

[0030] Step 4. Put plastic tape on the PDMS bottom piece, and add NaHCO in the middle slot 3 , so that it is firmly attac...

Embodiment 2

[0035] Step 1. Expose the glass chromium plate with a patterned film (the pattern includes the middle pump chamber and the driving U pipeline at the back, refer to 9 and 10 in the accompanying drawing), and then use 1mol / L HF acid solution to Etching for 0.5 hours and 4 hours serves as a template for the upper and lower PDMS sheets.

[0036] Step 2. Mix polydimethylsiloxane (PDMS) and curing agent at a ratio of 10:1, pour it on the glass mold, use a vacuum pump to remove air bubbles, and heat it in an oven at 60°C for 2 hours to make PDMS Cured, peeled off from the mold, and punched with a puncher at the outlet, as a PDMS top sheet.

[0037] Step 3. Add 0.5 μL of fluorosilane solution dropwise to the middle tank of the solid on the PDMS top sheet, and dry it under an infrared lamp.

[0038] Step 4. Put plastic tape on the PDMS bottom piece, and add CaCO in the middle slot 3 , so that it is firmly attached to the surface of the tape.

[0039] Step 5. Paste a plastic sheet on...

Embodiment 3

[0043] Step 1. Expose the glass chromium plate with a patterned film (the pattern includes the middle pump chamber and the driving U pipeline at the back, refer to 9 and 10 in the accompanying drawing), and then use 1mol / L HF acid solution to Etching for 0.5 hours and 4 hours serves as a template for the upper and lower PDMS sheets.

[0044] Step 2. Mix polydimethylsiloxane (PDMS) and curing agent at a ratio of 8:1, pour it on the glass mold, use a vacuum pump to remove air bubbles, and heat it in an oven at 80°C for 1 hour to make PDMS Cured, peeled off from the mold, and punched with a puncher at the outlet, as a PDMS top sheet.

[0045] Step 3. Add 0.3 μL of fluorosilane solution to the middle tank of the solid on the PDMS top sheet, and dry it under infrared light.

[0046] Step 4. Put plastic tape on the bottom of PDMS, and add CaHCO in the middle slot 3 , so that it is firmly attached to the surface of the tape.

[0047] Step 5. Paste a plastic sheet on the solid groo...

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Abstract

The invention relates to a triggerable and disposable microchip liquid pump based on chemical reaction, which comprises a solution filling tank 1 and an acidic solution tank 2. One end of the solution filling tank 1 is communicated with one end of the acidic solution tank 2 through micrometer tubes. A fluorosilane modified front small micrometer tube array 3 is arranged at the other end of the acidic solution tank 2 and is communicated with one end of an intermediate tank 4. A fluorosilane modified rear small micrometer tube array 5 is arranged at the other end of the intermediate tank 4 and can isolate liquid which flows into the intermediate tank 4 under the effect finger pressure. The rear small micrometer tube array 5 is connected with a gas guide passage and a gas guide passage 7 which generate gas. The triggerable and disposable microchip liquid pump based on chemical reaction is used as a part of a chip which is required to be driven by liquid and is designed and produced in a microchip. As long as the concentration of filling solution is changed and the quantity of solid reaction materials is enabled to be excessive, the driving effect to quantified liquid with different volumes can be realized and the chip structure and the finger tip pressure are not required to be changed. The invention additionally discloses a production method of the disposable microchip liquid pump.

Description

technical field [0001] The invention relates to a liquid pump on a microfluidic chip and its preparation, in particular to a disposable microchip liquid pump based on chemical reactions and which can be triggered. Background technique [0002] Microfluidics is a research field that emerged at the end of the 20th century based on the particularity of the micron structure. It is a research field that realizes a series of functional operations through the control of ultra-micro solutions in the micron structure. It is a technology-intensive and interdisciplinary research direction. . It can realize high-throughput, ultra-fast material screening, separation, enrichment, configuration regulation and identification through the control of ultra-trace liquid, and may even have a feedback recognition function. It has broad development prospects in the fields of precise scale bionics, drug screening and controlled release, real-time online life monitoring system, microelectronics and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00B01J19/00
Inventor 俞涛徐碧漪徐静娟陈洪渊
Owner NANJING UNIV
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