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Sustained release tablet containing theobromine

A technology of theobromine and sustained-release base, which is applied in the direction of medical preparations containing active ingredients, pill delivery, drug combination, etc., which can solve the problems of patient inconvenience, prolonged treatment time, and inability to maintain drug concentration, etc., to improve cough The effect of symptoms

Inactive Publication Date: 2014-02-12
AHN GOOK PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the drug release time of the capsule preparation introduced in Korean Patent No. 10-2008-9994 is too fast, so in order to achieve a good cough-relieving effect, the number of times of taking the drug must be more than 2 times a day, which brings inconvenience to the patient
In particular, when the patient cannot abide by the time of taking the medicine and cannot take the medicine on time, the concentration of the medicine in the blood cannot be maintained, so that the cough symptoms cannot be improved, and as a result, the treatment time becomes longer
[0007] However, the previously invented theobromine preparations need to be taken more than twice a day, which is the shortcoming of the existing theobromine preparations.

Method used

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  • Sustained release tablet containing theobromine
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  • Sustained release tablet containing theobromine

Examples

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Embodiment 1

[0028] Table 1 (unit: weight %)

[0029]

[0030] Table 2 (unit: weight %)

[0031]

[0032] Table 3 (unit: weight %)

[0033]

[0034] According to the structural proportions of the immediate-release layer recorded in the above Tables 1 to 3, the active substance "theobromine" and the excipient "microcrystalline cellulose" were mixed together, and hydroxypropyl cellulose was added here. After the granulation process, the above-mentioned granules are dried, and then coscamiles sodium and magnesium stearate are mixed here to produce an immediate-release layer compound.

[0035]Then, according to the structural proportions of the slow-release layer recorded in the above Tables 1 to 3, the active substance "theobromine" is mixed with microcrystalline cellulose and hydroxypropyl methylcellulose, and then added here The binding solution composed of propyl cellulose, after the wet granulation process, the above-mentioned granules are dried. After mixing polyethylene oxid...

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Abstract

The present invention relates to a sustained release tablet containing theobromine. More particularly, the present invention relates to a sustained release tablet containing theobromine, comprising a sustained release layer and an immediate release layer, wherein the sustained release layer consists of 40 to 60 wt % of theobromine as an active ingredient, and 14 to 19 wt % of a sustained release base consisting of polyethylene oxide and hydroxypropyl methylcellulose, and the immediate release layer consists of 10 to 30 wt % of theobromine as an active ingredient, and 0.5 to 2 wt % of a disintegrant consisting of one or more elements selected from among croscarmellose sodium, crospovidone and sodium starch glycolate. The sustained release table of the present invention effectively improves various types of cough symptoms by being taken just once per day.

Description

technical field [0001] The present invention relates to sustained-release lozenges containing theobromine, and in more detail, it relates to comprising: 40-60% by weight of theobromine or its salts, polyethylene oxide (polyethylene oxide) and hydroxypropyl methylcellulose (hydroxypropyl methyl cellulose) composed of 14-19% by weight of the slow-release base agent, 1-2% by weight of the binder, and 0.5-1% by weight of the lubricant; the slow-release layer consists of 10-30% by weight of theobromine or its salt, 0.5~2 of one of the three substances of croscarmellose natrium, crospovidone and sodium starch glycolate or two or more substances Theobromine-containing sustained-release lozenges with an immediate-release layer composed of a disintegrant, 0.3-1.5% by weight of a binder, and 0.1-0.5% by weight of a lubricant. Background technique [0002] As we all know, although coughing is a kind of human body defense function that also occurs in normal people, coughing caused by v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K31/522
CPCA61K9/2054A61K9/209A61K9/2059A61K9/2027A61K31/522A61K9/2031A61P11/14
Inventor 鱼津金昌焕韩昌均郑贤根金亮仲金钟杰尹柱勇李贞和
Owner AHN GOOK PHARMA CO LTD
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