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Application of trigonelline in preparation of medicament for preventing and treating diabetes and complication thereof

The technology of fenugreek and diabetes is applied in the field of pharmaceutical preparations for preventing and treating diabetes and its complications, and can solve the problems of unclarified safety and specific action mechanism, no reports of diabetes complications, single diabetes animal model, and the like, Achieve no effect on glucose and lipid metabolism, no toxic side effects, and clear functions

Active Publication Date: 2012-10-03
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although it has been reported that trigonelline can reduce the blood sugar level of diabetic rats, its safety and specific mechanism of action have not yet been elucidated. There is a single animal model of diabetes, and it is only observed that trigonelline can reduce KK-A y Blood sugar in diabetic mice and its possible mechanism of action, and its effect on the prevention and treatment of diabetic complications and its mechanism have not been reported at home and abroad
In order to further apply trigonelline to the prevention and treatment of diabetes and its complications, there are still many technical and mechanism problems, including the treatment of symptoms such as elevated blood lipids and tissue glucose and lipid metabolism disorders often accompanied by type 2 diabetes patients and diabetes complications. The impact of disease, and the impact on normal glucose and lipid metabolism

Method used

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  • Application of trigonelline in preparation of medicament for preventing and treating diabetes and complication thereof
  • Application of trigonelline in preparation of medicament for preventing and treating diabetes and complication thereof
  • Application of trigonelline in preparation of medicament for preventing and treating diabetes and complication thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] Obtaining Trigonelline

[0193] After the fenugreek was pulverized into coarse powder, it was extracted 3 times with 5 times the amount of 50% ethanol at room temperature for 24 hours each time, the filtrate was combined and filtered; concentrated under reduced pressure with a rotary evaporator; vacuum dried to obtain trigonelline, the extraction rate was 2.5 %.

Embodiment 2

[0195] Obtaining Trigonelline

[0196] After the fenugreek is pulverized into coarse powder, 10 times the amount is extracted with 95% ethanol at room temperature for 3 times, each 48h, the filtrate is combined, filtered; concentrated under reduced pressure with a rotary evaporator; vacuum dried to obtain trigonelline, the extraction rate is 3%.

Embodiment 3

[0198] Obtaining Trigonelline

[0199] After the fenugreek was pulverized into coarse powder, 12 times the amount was extracted with 70% ethanol for 3 times, each time for 2 hours, the filtrate was combined and filtered; concentrated under reduced pressure with a rotary evaporator; vacuum-dried to obtain trigonelline, the extraction rate was 4.1 %.

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Abstract

The invention relates to a medicament of a heterocyclic system containing a hexatomic ring using carbon as heterocyclic atoms, in particular to application of trigonelline in preparation of a medicament for preventing and treating diabetes and complication thereof. The medicament consists of 1 to 99.5 percent of trigonelline and pharmaceutically acceptable auxiliary materials. The medicament is an oral preparation such as tablets or capsules.

Description

technical field [0001] The invention relates to a medicinal preparation for preventing and treating diabetes and its complications, in particular to a medicine of a six-membered heterocyclic ring system containing nitrogen as a heterocyclic atom. Background technique [0002] At present, the globalized diabetes has become the third major disease that seriously endangers human health after tumors and cardiovascular and cerebrovascular diseases. According to the World Health Organization and the International Diabetes Federation, the total number of diabetic patients in the world is expected to reach 333 million by 2025. According to the results of the diabetes census published in 19 provinces and cities in my country, with the prolongation of the average life expectancy of the population, the increase of economic income and the change of lifestyle (such as more food and less exercise, mental stress, smoking and drinking, etc.), the total number of diabetic patients will be at...

Claims

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Application Information

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IPC IPC(8): A61K31/455A61P3/10A61P3/06
Inventor 周吉银周世文
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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