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Preparation method capable of improving yield of medium-molecular-weight hydroxyethyl starch

A technology of hydroxyethyl starch and molecular weight, applied in the field of amylopectin chemical derivatives, can solve the problems of large product loss and hydroxyethyl starch loss, and achieve the effects of stable and reliable quality, improved yield and reduced ultrafiltration times.

Active Publication Date: 2013-10-09
HEBEI GUOLONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the above process is in the ultrafiltration refining stage or the ultrafiltration concentration stage, there will be a greater loss of hydroxyethyl starch, and the more times of ultrafiltration refining, the higher the ultrafiltration concentration concentration, the greater the product loss
According to current patents and related literature reports, the yield of hydroxyethyl starch 130 / 0.4 and 200 / 0.5 is only 20%~38%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A preparation method for improving the yield of medium molecular weight hydroxyethyl starch, comprising the following steps:

[0040] (1) Add 350g of medical amylopectin starch into 1000mL of purified water, stir evenly, add concentrated hydrochloric acid to make the concentration of HCl 0.04mol / L, make a reaction solution, heat the reaction solution vapor to 90°C, and stir until the reaction The kinematic viscosity of the liquid is 22 mm 2Stop heating after / s, rapidly cool to 30°C, add NaOH to neutralize until the reaction liquid is neutral during the cooling process;

[0041] (2) Add NaOH to the reaction solution after the reaction in step (1), the concentration of NaOH is 0.8mol / L, add ethylene oxide after vacuuming, keep the reaction at 20°C for 6 hours, after the reaction, add 1000mL of purified water dilution;

[0042] The molar ratio of amylopectin to ethylene oxide is 1:0.7;

[0043] (3) Use concentrated hydrochloric acid to adjust the pH value of the reacti...

Embodiment 2

[0047] A preparation method for improving the yield of medium molecular weight hydroxyethyl starch, comprising the following steps:

[0048] (1) Add 350g of medical amylopectin starch into 1000mL of purified water, stir evenly, add concentrated hydrochloric acid to make the concentration of HCl 0.06mol / L, make a reaction solution, heat the reaction liquid vapor to 80°C, and stir until the reaction The kinematic viscosity of the liquid is 21 mm 2 Stop heating after / s, rapidly cool to 30°C, add NaOH to neutralize until the reaction liquid is neutral during the cooling process;

[0049] (2) Add NaOH to the reaction solution after the reaction in step (1), the concentration of NaOH is 0.9mol / L, add ethylene oxide after vacuuming, keep the reaction at 35°C for 7 hours, after the reaction, add 1000mL purification water dilution;

[0050] The mol ratio of amylopectin and ethylene oxide is 1:0.75;

[0051] (3) Use concentrated hydrochloric acid to adjust the pH value of the reacti...

Embodiment 3

[0055] A preparation method for improving the yield of medium molecular weight hydroxyethyl starch, comprising the following steps:

[0056] (1) Add 350g of medical amylopectin starch into 1000mL of purified water, stir evenly, add concentrated hydrochloric acid to make the concentration of HCl 0.08mol / L, make a reaction solution, heat the reaction solution vapor to 95°C, and stir until the reaction The kinematic viscosity of the liquid is 24 mm 2 Stop heating after / s, rapidly cool to 30°C, add NaOH to neutralize until the reaction liquid is neutral during the cooling process;

[0057] (2) Add NaOH to the reaction liquid after the reaction in step (1), the concentration of NaOH is 1.0mol / L, add ethylene oxide after vacuuming, keep the reaction at 15°C for 8 hours, after the reaction, add 1000mL purification water dilution;

[0058] The mol ratio of amylopectin and ethylene oxide is 1:0.8;

[0059] (3) Use concentrated hydrochloric acid to adjust the pH value of the reactio...

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Abstract

The invention discloses a preparation method capable of improving yield of medium-molecular-weight hydroxyethyl starch, and belongs to the technical field of amylopectin chemical derivatives. The method includes the steps: firstly, adding amylopectin and hydrochloric acid into water and heating for hydrolyzing; secondly, adding etherifying agent and preserving heat for reaction; thirdly, adjusting pH (potential of hydrogen) value of reaction solution to range from 5 to 7, decoloring, leaching and filtering; fourthly, ultrafiltering and then electrodialyzing; and fifthly, nano-filtrating for concentration and spray-drying to obtain medium-molecular-weight hydroxyethyl starch. By means of the membrane refining process which combines ultrafiltration and electrodialysis, ultrafiltration times are greatly reduced, the refining process is shortened, and product yield and quality are improved. Further, by means of the process of nano-filtrating for concentration before spray-drying, spray-drying efficiency can be improved while yield of the hydroxyethyl starch can be improved. Additionally, products made by the method are low in sodium chloride and stable and reliable in quality; and since water is used as a dispersion medium, production safety is realized, and pollution is avoided.

Description

technical field [0001] The invention belongs to the technical field of pullulan chemical derivatives. Background technique [0002] Due to the shortage of clinical blood sources and the potential risk of blood-borne disease transmission, it is extremely important to study good plasma substitutes for volume therapy. The use of plasma substitutes can reduce blood transfusion or avoid blood transfusion in patients with blood loss. Therefore, plasma substitutes have developed rapidly in the past ten years. Plasma substitutes are mainly used in emergencies such as hypovolemia and shock caused by massive blood loss, plasma loss, and extensive burns to expand blood volume and improve microcirculation, thereby increasing the survival rate of patients. An ideal plasma substitute should have stable physical and chemical properties, be able to quickly replenish blood volume, increase tissue perfusion and have sufficient residence time in blood vessels, improve oxygen supply and organ ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/12
Inventor 赵雄燕王虹王明珠郑小伟殷殿书印杰
Owner HEBEI GUOLONG PHARMA CO LTD
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