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Composition with auxiliary protection effect on chemical liver injury and preparation method of composition

A technology for chemical liver injury and protection, applied in medical preparations containing active ingredients, food preparation, drug combinations, etc., can solve the problems of unclear toxicological hazards, unclear mechanism of action, and unknown active ingredients.

Inactive Publication Date: 2012-09-19
广州市奥海生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various liver-protecting prescriptions have appeared in modern times, but the traditional Chinese medicine decoction method is mostly used in the production methods, the active ingredients are unknown, the mechanism of action is unclear, and sufficient pharmacological and pathological explanations have not been provided, and no relevant animal or human studies have been carried out. Test, toxicological hazard is not clear

Method used

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  • Composition with auxiliary protection effect on chemical liver injury and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Ingredients: Schisandra 30g, Pueraria 50g, Hovenia dulcis 30g, licorice 20g

[0029] After crushing the schisandra and kudzu root in the weight ratio, extract with Hovenia dulcis and licorice plus 10 times the amount of 70% ethanol for 3 times, each time for 2 hours, the extracts are combined, filtered, and the filtrate is decompressed to recover ethanol, dried under reduced pressure, Crush into fine powder, add appropriate amount of mannitol and aspartame, mix well, granulate with 85% ethanol, dry, granulate to obtain granules.

Embodiment 2

[0031] Ingredients: Schisandra 50g, Pueraria 50g, Hovenia dulcis 50g, licorice 5g

[0032] After crushing the schisandra and kudzu root in the weight ratio, extract with Hovenia dulcis and licorice plus 6 times the amount of 95% ethanol for 4 times, each time for 1 hour, the extracts are combined, filtered, the filtrate is decompressed to recover ethanol, and dried under reduced pressure. Crush into fine powder, add appropriate amount of dextrin and sucrose, mix well, granulate with 85% ethanol, dry, and granulate to obtain granules.

Embodiment 3

[0034] Raw materials: Schisandra 20g, Pueraria 60g, Hovenia dulcis 20g, licorice 40g

[0035] After crushing the schisandra and kudzu root in the weight ratio, extract once with Hovenia dulcis and licorice plus 12 times the amount of 50% ethanol, each time for 3 hours, the extracts are combined, filtered, the filtrate is decompressed to recover ethanol, and dried under reduced pressure. Crush into fine powder, add appropriate amount of auxiliary materials, mix well, granulate with 85% ethanol, dry, and granulate to obtain granules.

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PUM

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Abstract

The invention relates to a composition with an auxiliary protection effect on chemical liver injury and a preparation method of the composition. The composition with the auxiliary protection effect on the chemical liver injury comprises the following ingredients in parts by weight: 1 to 10 parts of schisandra chinensis, 1 to 15 parts of kudzuvine root, 1 to 10 parts of hovenia dulcis thumb and 0.1 to 10 parts of liquorice. The composition provided by the invention belongs to a composition which is screened on the basis of the existing traditional Chinese medicine theory and has the auxiliary protection effect on the chemical liver injury, through scientific matching, the mutual synergistic effect is realized, and experiments prove that the composition belongs to the composition with the auxiliary protection effect on the chemical liver injury and can be further prepared into health-care food or medicine with the auxiliary protection effect on the chemical liver injury.

Description

technical field [0001] The invention belongs to the field of health food and medicine, and relates to a composition with auxiliary protective effect on chemical liver damage and a preparation method thereof. Background technique [0002] Liver injury is a common clinical disease that endangers human health. Liver injury involves a wide range of pathological factors, such as viruses, organisms, drugs, physical chemistry, alcohol, etc., can all lead to liver injury. [0003] Chemical liver injury is liver injury caused by chemical hepatotoxic substances. These chemicals include alcohol, chemical toxins in the environment, and certain drugs. As an important detoxification organ of the human body, the liver has dual blood supply from the hepatic artery and the hepatic vein. Chemicals can enter the liver through the portal vein of the gastrointestinal tract or the systemic circulation for transformation, so the liver is vulnerable to toxic substances in chemicals. There are so...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61P1/16A23L1/29A23L33/00
Inventor 张胜黄东林温婉虹
Owner 广州市奥海生物科技有限公司
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