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Penicillin borneol composition

A penicillin and composition technology, applied in the field of penicillin borneol composition, can solve problems such as increase of drug-resistant bacteria, insignificant treatment effect of penicillin, increase in drug sensitivity, etc., and achieves improvement of drug resistance phenomenon, good antibacterial activity and application prospect expansive effect

Inactive Publication Date: 2012-09-19
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a penicillin borneol composition to improve the sensitivity of these drug-resistant strains to drugs in view of the deficiencies in the prior art, such as the increase of drug-resistant bacteria and the ineffective treatment effect of penicillin.

Method used

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  • Penicillin borneol composition
  • Penicillin borneol composition
  • Penicillin borneol composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 antibacterial experiment

[0020] Get the penicillin borneol antibacterial composition and carry out antibacterial experiment.

[0021] Simple borneol group:

[0022] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8mL of borneol liquid, take out 4mL of the mixed solution from tube 1 by the 2-fold dilution method, place it in test tube 2 containing 4mL of LB medium, and mix Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial suspension with a turbidity of 1 McFarland unit to each tube, and shake well.

[0023] Penicillin alone group:

[0024] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8mL of penicillin liquid, take out 4mL of the mixed solution from tube 1 by the 2-fold dilution method, place it in test tube 2 containing 4mL of LB medium, and mix Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial...

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Abstract

The invention discloses a penicillin borneol composition, which belongs to the technical field of preparation of medicaments. The penicillin borneol composition consists of penicillin and borneol in the mass ratio of 1:0.1-1:10, wherein the optimal mass ratio is 1:1. The composition can be prepared into various dosage forms such as tablets, capsules, particles, a sustained release agent, an injection and the like together with pharmaceutically-general auxiliary materials with the conventional medicament preparation method. The composition has a good inhibiting action on a plurality of medicament-resistant bacteria and a wide application prospect; and the order of magnitude of the MIC (Minimal Inhibitory Concentration) value is lowered, so that phenomenon of medicament resistance existing in the conventional antibiotics is greatly improved.

Description

technical field [0001] The invention relates to the field of antibacterial drugs, in particular to a penicillin borneol composition. Background technique [0002] Penicillin, whose chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetylamino)-4-thia-1-azabicyclo[3.2 .0] Heptane-2-carboxylic acid potassium salt, formula C 16 h 18 N 2 o 4 S, structural formula such as formula ( ) [0003] [0004] ( ) [0005] This product is a β-lactam antibiotic, which has good antibacterial effect on Streptococcus such as hemolytic Streptococcus, Streptococcus pneumoniae and Staphylococcus that does not produce penicillinase. It has moderate antibacterial effect on Enterococcus, Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptococcus moniliforme, Listeria monocytogenes, Leptospira and Treponema pallidum This product is sensitive. This product also has certain antibacterial activity against Haem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61P31/04A61K31/045
CPCY02A50/30
Inventor 李明亚陈燕忠冼嘉雯
Owner GUANGDONG PHARMA UNIV
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