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Preparation method of soft capsule without gelatin

A soft capsule and gelatin technology, applied in the direction of capsule delivery, etc., can solve the problems of poor bioavailability, uneven quality, lack of management, etc., and achieve the effects of improving the level of science and technology, ensuring physical health, and product safety and reliability

Inactive Publication Date: 2012-09-19
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 5. Drugs with volatile components and easy to escape
[0010] 6. Hydrophobic drugs with poor bioavailability
For a long time, there have been some deficiencies in the quality inspection of soft capsule shells, coupled with the lack of management in the domestic gelatin market, the quality is uneven, and some people even use industrial gelatin prepared from leather base rubber to prepare soft capsules, making traditional gelatin soft capsules There are many safety hazards in the quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 100g of pullulan and 3g of xanthan gum, mix them evenly, add 50g of glycerin, then add 500mL of deionized water, mix them evenly, place them in a constant temperature water bath at 70°C for heating and stirring to dissolve, place them in a 0.09~0.1Mpa Degassing under vacuum for 30 minutes, then poured into a film forming device, dried in a drying oven at 60-70°C for 12 hours, and peeled off the film. Two gelatin-free diaphragms made by the above-mentioned process are respectively placed on the two rollers of the rotary film method soft capsule pressing machine, then soft capsule molding is carried out according to the conventional gelatin soft capsule pressing process, and the obtained gelatin capsules are formed while molding. Medicines or health food that need to be filled are packed into soft capsules. The prepared soft capsules are similar to gelatin soft capsules in terms of transparency, elasticity and mechanical strength, and the disintegration time limit m...

Embodiment 2

[0027] Weigh 100g of pullulan and 4g of carrageenan, mix well, add 60g of glycerin, then add 700mL of deionized water, mix well, heat and stir in a constant temperature water bath at 70°C to dissolve, and place in a vacuum of 0.09~0.1Mpa Degassing at high temperature for 30 minutes, then poured into the film forming device, dried in a drying oven at 60~70°C for 14 hours, and peeled off the film. Put two gelatin-free diaphragms prepared by the above-mentioned process on the two rollers of the rotary film method soft capsule manufacturing machine, then carry out soft capsule molding according to the pressing process of conventional gelatin soft capsules, and place the gelatin capsules at the same time as molding. The medicine that needs to be filled is put into the soft capsule. The prepared soft capsules are similar to gelatin soft capsules in terms of transparency, elasticity and mechanical strength, and the disintegration time limit meets the standard stipulated in the 2005 e...

Embodiment 3

[0029] Weigh 100g of pullulan polysaccharide and 2g of gellan gum, mix well, add 70g of glycerin, then add 900mL of deionized water, mix well, place in a constant temperature water bath at 70°C to heat and stir to dissolve, place in a 0.09~0.1Mpa Degassing under vacuum for 30 minutes, then poured into a film forming device, dried in a drying oven at 60~70°C for 18 hours, and peeled off the film. Put two gelatin-free diaphragms prepared by the above-mentioned process on the two rollers of the rotary film method soft capsule manufacturing machine, then carry out soft capsule molding according to the pressing process of conventional gelatin soft capsules, and place the gelatin capsules at the same time as molding. The medicine that needs to be filled is put into the soft capsule. The prepared soft capsules are similar to gelatin soft capsules in terms of transparency, elasticity and mechanical strength, and the disintegration time limit meets the standard stipulated in the 2005 e...

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Abstract

A preparation method of a soft capsule without gelatin belongs to the technical filed of processing of soft capsules. The preparation method is that pullulan taken as major ingredient is respectively mixed with xanthan gum, carrageenan or gellan gum and other microbial polysaccharide gum or seaweed polysaccharide gum, the mixture is subjected to such procedures as sol, degassing, drooling and drying to form a gum skin film, and the gum skin film is pressed through a soft capsule pressing machine via a film rotating method to form the soft capsule. According to the invention, the soft capsule only adopts the pullulan, xanthan gum or carrageenan and other microbial polysaccharide gum or seaweed polysaccharide gum as the raw materials, and does not use the gelatin, adopts two processes of drooling to form the film and soft capsule pressing through the film rotating method; and meanwhile, during pressing, any oil-soluble drugs or health care food can be installed, so that the soft capsule without gelatin can be made.

Description

technical field [0001] The invention discloses a method for preparing gelatin-free soft capsules, which belongs to the technical field of soft capsule processing. Background technique [0002] Soft capsules refer to capsules in which medicinal material extracts, liquid medicines or appropriate excipients are mixed evenly and then sealed in soft capsules by dripping or pressing methods. They are prepared by dripping or pressing methods, and their shapes are round, Oval shape, fish shape, tube shape etc. According to statistics, in the current new drug development process, more than 40% of the new chemical systems exhibit poor biopharmaceutical properties, such as low solubility or poor permeability. These deficiencies pose a serious challenge to the development of orally absorbable compounds and oral formulations. The development of soft capsule preparations has made up for the poor water solubility of some oral compounds to a certain extent. Compared with other oral prepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 童群义连正淦
Owner JIANGNAN UNIV
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