Esomeprazole magnesium enteric-coated pellet and preparation method thereof

Abstract

The invention belongs to the field of pharmacy and relates to a medicinal preparation taking esomeprazole magnesium as an active ingredient, in particular to an esomeprazole magnesium enteric-coated pellet and a preparation method thereof. According to the esomeprazole magnesium enteric-coated pellet, medicines can be rapidly released in intestinal tracts. The esomeprazole magnesium enteric-coated pellet comprises the following structural layers in sequence from inside to outside: a medicine-contained layer, an isolation layer and an enteric-coated layer.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a pharmaceutical preparation with esomeprazole magnesium as an active ingredient, in particular to an esomeprazole magnesium enteric-coated pellet and a preparation method thereof. Background technique [0002] The structural formula of esomeprazole magnesium is: [0003] [0004] Esomeprazole is the left-handed isomer of omeprazole, and is the first pure left-handed optical isomer proton pump inhibitor (PPI). It was approved for marketing in the United States and European countries in 2001. The original research company Aspen Tera applied for a compound patent (ZL94190335.4) in my country. The original research company launched esomeprazole, a replacement product of omeprazole, in 2002, another optical isomer of esomeprazole and omeprazole ( Compared with R)-omeprazole, only a small part is metabolized by CYP2C19, so esomeprazole exhibits low metabolic rate and high plasma concentration....

AI Technical Summary

Problems solved by technology

Chinese patent 201110007462.2 uses a centrifuge to sprinkle powder and granulate pellets. The yield is low, the material loss is large, the environment is polluted, the working hours are long, and the production process has a lot of factors affecting product quality.

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