Method of complex frequency-domain optical coherence tomography using differential sinusoidal phase modulation

Abstract

A method of complex frequency-domain optical coherence tomography using differential sinusoidal phase modulation includes: based on complex frequency-domain optical coherence tomography using differential sinusoidal phase modulation, introducing sinusoidal phase modulation to transverse scan interference signals, subjecting acquired interference spectral signals to inverse Fourier transform along the wave-number direction, using a phase difference of adjacent complex tomographic signals to replace phases of complex tomographic signals obtained in conversion so that new differential complex tomographic signals are formed, respectively subjecting a real part and an imagery part of each differential complex tomographic signal to phase demodulation prior to addition so as to obtain mirror-removed complex tomographic signals, and removing amplitude to obtain a full-depth structural tomographic map of a tested sample. By the method, complex conjugate mirror images, direct current background and autocorrelation noise in the frequency-domain optical coherence tomographic images are eliminated, sensitivity does not decrease with increase of transverse scanning distance, the affection of internal high-speed movement of a sample on mirror image elimination is reduced, and the method is applicable to in vivo imaging of biological samples.

Description

Technical field [0001] The present invention relates to frequency domain optical coherence tomography (Fourier-Domain Optical Coherence Tomography, FD-OCT for short), in particular to a differential sine phase modulation complex frequency domain optical coherence tomography method. Background technique [0002] Optical Coherence Tomography (OCT) technology is a non-invasive high-resolution imaging method that can perform in-vivo non-destructive tomography imaging within a few millimeters of depth in biological tissues, and is widely used in ophthalmology and skin Diagnosis and research in many medical fields. [0003] Frequency-domain optical coherence tomography (FD-OCT) is a new type of OCT imaging technology. Traditional time-domain OCT uses low-coherence optical interferometry technology to obtain the reflection of changes in the depth of the sample by mechanically scanning the sample along the depth direction Rate information (A-line); then through lateral scanning, tomograph...

AI Technical Summary

Problems solved by technology

However, this method extracts the fundamental frequency and double frequency harmonic components through a low-pass filter to reconstruct the complex interference spectrum signal, which has little redundancy for the motion of the measured sample, and is not suitable for in vivo imaging of biological samples.

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