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Synthesis method of allopurinol

A synthesis method, the technology of allopurinol, applied in the field of synthesis of chemical raw materials, can solve problems such as low yield and complicated method, achieve the effects of reduced environmental pollution, simple process, and improved product yield and quality

Inactive Publication Date: 2012-08-22
ZHEJIANG RUIQING PHARM C0 LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The synthetic method of the present existing allopurinol synthetic method is that the method is complicated, and the productive rate is very low

Method used

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  • Synthesis method of allopurinol
  • Synthesis method of allopurinol
  • Synthesis method of allopurinol

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Embodiment Construction

[0023] Typical embodiments embodying the features and advantages of the present invention will be described in detail in the following description. It should be understood that the present invention is capable of various changes in different embodiments without departing from the scope of the present invention, and that the descriptions therein are illustrative in nature rather than limiting the present invention.

[0024] The synthetic method of the present invention is as follows:

[0025] Step 1: Condensation reaction:

[0026]

[0027] Condensation process: The feeding ratio is as follows:

[0028] name Proportion Triethyl orthoformate 2±1.5W Morpholine 1.2±1W Acetonitrile 0.45±0.3W cyanoacetamide 1W

[0029] Operation process:

[0030] Put triethyl orthoformate, morpholine, acetonitrile, and cyanoacetamide into the reaction tank in sequence according to the weight ratio, and stir. Steam heated, warming to reflux. Duri...

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Abstract

The invention discloses a synthesis method of allopurinol, which comprises the following steps of: 1) condensation reaction; 2) ring salt synthesis reaction; 3) treatment at a crude product section; and 4) treatment at a refining section. The synthesis method provided by the invention has the advantages that the process is simple, the product yield and quality can be effectively improved through the process provided by the invention, the energy consumption and the environmental pollution are reduced during reaction and purified water is used for refining the allopurinol.

Description

technical field [0001] The present invention relates to a kind of synthetic method of chemical raw material, more specifically, the present invention relates to a kind of synthetic method of allopurinol. Background technique [0002] Allopurinol, chemical name: 4-hydroxypyrazolo[3,4-d]pyrimidine; 1H-pyrazolo[3,4-d]pyrimidin-4-ol English name: Allopurinol [0003] Molecular formula: C 5 h 4 N 4 O, molecular weight: 136.11. [0004] Structural formula: [0005] [0006] Physical and chemical properties: This product is white or off-white crystalline powder, odorless, melting point above 320°C (dissolution point), soluble in lye, slightly soluble in water and ethanol, insoluble in chloroform and ether. [0007] Function and usage: It is mainly used for gout caused by the increase of uric acid after eating high protein, and has an auxiliary therapeutic effect on leukemia. [0008] The synthesis method of the existing allopurinol synthesis method is that the method is co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04
Inventor 朱国胜黄骥武
Owner ZHEJIANG RUIQING PHARM C0 LTD
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