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Application of prenylated flavonoid compound

A kind of technology of isopentenyl flavonoid and compound, applied in the field of medicine

Inactive Publication Date: 2012-07-25
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no prenyl flavonoid compound of the present invention in the prior art---anhydroicariin and 2 "-hydroxyl-3"-ene-anhydroicariin as active ingredients in the treatment of osteoarthritis. Reports on osteoporosis

Method used

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  • Application of prenylated flavonoid compound
  • Application of prenylated flavonoid compound
  • Application of prenylated flavonoid compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: The preparation of prenyl flavonoids --- dehydroicariin (I) and 2"-hydroxy-3"-ene-anhydroicariin (II), the specific steps are as follows:

[0037] Take dried Epimedium ( Epimedium brevicorum Maxim) whole herb 12 kg was pulverized, according to the mass / volume ratio of Epimedium: Acetone aqueous solution = 1:3, the concentration of 75% acetone aqueous solution was used to extract Epimedium three times at room temperature, and the amount of acetone water each time was 36 L, soaked for 24 hours, after combining the extracts for 3 times, distilled under reduced pressure until there is no acetone smell; according to the volume ratio of extract:petroleum ether=1:1, the extract was first extracted three times with petroleum ether at room temperature, The amount of petroleum ether used is 10 L each time. After the petroleum ether is recovered, the extract is obtained; according to the volume ratio of the extract: ethyl acetate = 1:1, the extract is extracted three ...

Embodiment 2

[0039] Embodiment 2: with Prenyl flavonoids are tablets prepared as active ingredients, and the tablet components and contents are as follows:

[0040] Active ingredient---prenyl flavonoid compound (I or II) 10mg

[0041] Lactose 156mg

[0042] Corn starch 55mg

[0043] Calcium Stearate 4mg

[0044] Preparation method: mix the active ingredients, lactose, and cornstarch, moisten them evenly with water until they can be kneaded into agglomerates, press to make soft materials that are easy to disperse, dry at 60-80°C, sieve, add calcium stearate, and mix well Finally, it is compressed into tablets, each tablet weighs 225 mg, and the active ingredient content is 10 mg.

Embodiment 3

[0045] Embodiment 3: with Prenyl flavone compound is the spray prepared by the active ingredient, and its components and contents are as follows:

[0046] Active ingredient prenylflavone compound (I or II) 8mg

[0047] Sodium chloride 9mg

[0048] EDTA 0.5mg

[0049] Sodium Phosphate Buffer (PH6.5) 10mg

[0050] Add distilled water to 2ml

[0051] Preparation method: Add each solid component in distilled water in turn to dissolve completely, filter and sterilize through a microporous membrane, and bottle it.

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PUM

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Abstract

The invention discloses a novel application of prenylated flavonoid compound, and particularly relates to application of the prenylated flavonoid compound. The application includes that anhydroicaritin and 2'- hydroxyl-3'- alkene- anhydroicaritin are used as active agents for preparing medicines which resist osteoporosis and promote bone repair. An experiment result shows that the compound has a remarkable anti-osteoporosis effect, is low in toxicity and high in safety, and can be used as an anti-osteoporosis medicine.

Description

Technical field [0001] The present invention involves isoprene flavonoids-dehydrated 淫 淫 素 and 2"-hydroxyl-3"--dehydrated 淫 淫Application belongs to the field of pharmaceutical technology. Background technique [0002] Orthopedic loosening is a health issue that has attracted much attention from the world.About 75 million women in the United States, Europe, and Japan suffer from osteoporosis after menopause, and the treatment of osteoporosis is $ 23 billion per year.The complications of osteoporosis after fracture of osteoporosis include: disability, paralysis, respiratory dynamic disorders, and pain.Social burden far exceeds direct medical expenses.As the aging society is approaching, the development of osteoporosis drugs is becoming more and more urgent.Although estrogen replacement therapy is effective, long -term application can increase the incidence of endometrial and breast cancer, which restricts its application.The development of estrogen -like analogs with tissue specifi...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P19/10A61P19/08
Inventor 李蓉涛李艳平邓旭亮李洪梅李海舟
Owner KUNMING UNIV OF SCI & TECH
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