Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles

A granule and Agui technology, applied in the field of medicine, can solve problems affecting clinical efficacy and product quality

Active Publication Date: 2012-07-18
JIANGXI JIMINKEXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the volatile oil is directly mixed with the granules, the prepared volatile oil often volatilizes, which affects the quality of the product and affects the clinical efficacy. Therefore, it is necessary to include the above-mentioned volatile oil. This technology has not been applied in Agui Yangxue Granules, and related technologies have not been reported yet.

Method used

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  • Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles
  • Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 【prescription】

[0060] Angelica 386g Codonopsis 24g White peony root 24g

[0061] Licorice (Honey Roast) 12g Poria 24g Astragalus 24g

[0062] Rehmannia glutinosa 24g Chuanxiong 12g donkey-hide gelatin 24g

[0063] Its [preparation method] is as follows:

[0064] The nine medicinal materials in the prescription, except donkey-hide gelatin, the other eight herbs such as angelica and codonopsis, are crushed into coarse powder, mixed evenly, and 60% ethanol is used as solvent, and continuous countercurrent extraction is used. The extract is recovered with ethanol, concentrated to an appropriate amount, and collected after standing still. The oil that floats up is clathrated with cyclodextrin, and the remaining concentrate is collected in another device; the dregs are decocted with water for 1 hour, filtered, and the filtrate is concentrated to an appropriate amount, and left to stand for 24 hours. Pour the above two concentrated liquid medicines, mix them well, then ad...

Embodiment 2

[0067] The following prescription process is used to further illustrate the preparation of Agui Yangxue Granules but is not limited to the present invention

[0068] 【prescription】

[0069] Angelica 386g Codonopsis 24g White peony root 24g

[0070] Licorice (Honey Roast) 12g Poria 24g Astragalus 24g

[0071] Rehmannia glutinosa 24g Chuanxiong 12g donkey-hide gelatin 24g

[0072] Its [preparation method] is as follows:

[0073] Prescription Craft 1

[0074]

[0075] Mix sucrose and dextrin, add clathrate and oil inclusion compound to prepare soft material, granulate with 18 mesh, dry at 60°C, control moisture content to less than 2.5%, granulate, inspect, and repackage after passing the test.

[0076] Among them, the preparation of cyclodextrin inclusion compound: weigh 60 g of β-cyclodextrin, add 1 times the amount of purified water, and grind evenly. The oily substance is equivalent to 1 times the prescription amount (about 5g), dissolved in an appropriate amount of e...

Embodiment 3

[0078] 【prescription】

[0079] Angelica 386g Codonopsis 24g White peony root 24g

[0080] Licorice (Honey Roast) 12g Poria 24g Astragalus 24g

[0081] Rehmannia glutinosa 24g Chuanxiong 12g donkey-hide gelatin 24g

[0082] Its [preparation method] is as follows:

[0083] Recipe Craft 2

[0084]

[0085] Mix sucrose and dextrin, add clathrate and oil inclusion compound to prepare soft material, granulate with 18 mesh, dry at 60°C, control moisture content to less than 2.5%, granulate, inspect, and repackage after passing the test.

[0086] Among them, the preparation of cyclodextrin inclusion compound: weigh 60 g of β-cyclodextrin, add 1 times the amount of purified water, and grind evenly. The oily substance is equivalent to 1 times the prescription amount (about 5g), dissolved in an appropriate amount of ethanol (1-5g), added dropwise to the evenly ground β-cyclodextrin, and ground for 4 hours. The optimum ratio of oil to ethanol is 5:3.

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Abstract

The invention relates to a new preparation method of donkey-hide gelatin and Angelica blood-nourishing particles, and belongs to the technical field of medicines. The formula of the donkey-hide gelatin and Angelica blood-nourishing particles is composed of the following components: 386 g of Angelica, 24 g of radix codonopsitis, 24 g of white peony roots, 12 g of honey-processed licorice, 24 g of tuckahoe, 24 g of astragalus root, 24 g of prepared rehmannia root, 12 g of hemlock parsley and 24 g of donkey-hide gelatin.

Description

field of invention [0001] The invention relates to a new preparation method of Agui Yangxue Granules, belonging to the technical field of medicine. Background technique [0002] Agui Yangxue Granules are granules processed from angelica, donkey-hide gelatin, Codonopsis pilosula, white peony and other medicinal materials. After the prepared granules are dry, add volatile oil and mix well. Because the volatile oil is directly mixed with the granules, the finished volatile oil often volatilizes, which affects the quality of the product and affects the clinical efficacy. Therefore, it is necessary to include the above-mentioned volatile oil. This technology has not been applied to Agui Yangxue Granules, and related technologies have not been reported yet. [0003] Cyclodextrin is a cyclic oligosaccharide compound obtained from starch with more than six D-glucopyranose units connected by 1,4-glycosidic bonds. The unique structure of cyclodextrins enables them to form host-guest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K47/40A61P1/14A61P7/06A61P15/00
Inventor 文万江彭常春何平清赵有红
Owner JIANGXI JIMINKEXIN PHARMA
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