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Carrier polypeptide for forming medical compositions and preparation method and application of carrier polypeptide

A technology for carrier polypeptides and drugs, applied in chemical instruments and methods, non-active components of polymer compounds, peptides, etc., can solve the problems of low bioavailability, short half-life, poor stability, etc., to reduce drug intake and prolong concentration. time, the effect of reducing medical costs

Active Publication Date: 2014-04-09
天津药物研究院药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Proteins and peptides also have outstanding problems, such as imperfect drug delivery systems, poor stability, short half-life in vivo, low bioavailability, etc.

Method used

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  • Carrier polypeptide for forming medical compositions and preparation method and application of carrier polypeptide
  • Carrier polypeptide for forming medical compositions and preparation method and application of carrier polypeptide
  • Carrier polypeptide for forming medical compositions and preparation method and application of carrier polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The preparation of embodiment 1 carrier polypeptide 1-4

[0058] Using the solid-phase peptide synthesis method of the Fmoc strategy, the CS 336X instrument produced by CSBio Company was used to synthesize carrier peptides 1-4. The method of synthesis was carried out according to the manufacturer's instruction manual.

[0059] The prepared polypeptide was purified using HPLC C18 semi-preparative column, and the mobile phase was acetonitrile. The polypeptide freeze-dried powder is obtained by desalting and freeze-drying.

Embodiment 2

[0060] Example 2 Complex of Small Molecule Drug and Carrier Polypeptide 1

[0061] Polar small-molecule drugs choose penicillin drug amoxicillin, according to the molar ratio (the following ratios are not indicated as the same molar ratio) the ratio of amoxicillin to carrier polypeptide 1 is 10:1.

[0062] Weigh amoxicillin, dissolve it in normal saline to form a 1mmol / L solution, mix thoroughly, weigh 0.1mmol carrier polypeptide 1, dissolve it in 1L of the above normal saline, mix well, and mix by ultrasonic at 4°C After 5 minutes, the complex solution was obtained and lyophilized.

Embodiment 3

[0063] The complex of embodiment 3GLP-1 polypeptide and carrier polypeptide 1

[0064] Weigh 0.3 mg of GLP-1 lyophilized powder, dissolve it in 1 ml of normal saline, mix well, weigh 3.3 mg of carrier polypeptide 1 lyophilized powder, dissolve it in the above GLP-1 normal saline, mix well, and °C, stirred for 3 hours, and freeze-dried to obtain a solid powder of the complex.

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Abstract

The invention provides a carrier polypeptide, a preparation method of the carrier polypeptide, carrier agents based on the carrier polypeptide and medical compositions prepared by the carrier agents, wherein the carrier polypeptide has a general formula of GLWWX1X2WWX3X4WWX5X6X7WWX8X9X10X11X12X13X14. The carrier agents can prolong duration time of concentration of the carrier agents in bodies and has a sustained-release function. Besides, according to the medical compositions prepared by the carrier agents, medicine uptake is reduced, so that medical treatment cost is decreased.

Description

technical field [0001] The present invention relates to the field of pharmaceutical excipients. Specifically, the present invention relates to a carrier polypeptide and its preparation method and application. ) The ability to form a complex can increase the stability of the drug to degradation factors in the body and prolong its half-life in the body. Background technique [0002] Research on biotechnology drugs (especially proteins and peptides) as drugs has achieved rapid development. In a survey report in 2009, 324 biotechnology drugs (including clinical trials or drugs under review by regulatory authorities) covered almost 150 diseases, including cancer, autoimmune diseases, and infectious diseases such as AIDS. Proteins and peptides also have outstanding problems, such as imperfect drug delivery systems, poor stability, short half-life in vivo, and low bioavailability. It is a common method to optimize the metabolic kinetic properties of proteins through modification ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/00A61K47/42
Inventor 龚珉徐为人任晓文王玉丽付刚汤立达郑学敏刘鹏
Owner 天津药物研究院药业有限责任公司
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