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Multilayered composite tube, manufacturing method thereof, and application thereof

A tube and inner layer technology, applied in the field of medical devices, can solve the problems of imperfect drug release system, drug shedding, drug loss, etc., to save spraying drugs, improve production efficiency, and shorten the production process.

Active Publication Date: 2014-06-11
SHANDONG HUAAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the uniformity of the drug on the surface of the stent is also challenged
[0018] What's more deadly is that in order to ensure the support of the stent, the micropores etched on the surface can only exist in the micron-level depth of the inner and outer surfaces, and the embedded drug will fall off in large quantities when it is washed by external force or blood
In particular, the force deformation of the stent during the assembly process and the friction during the implantation process will lose a large amount of drugs, causing fatal damage to the imperfect drug release system, and the implanted stent cannot play the role of the initial setting well.

Method used

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  • Multilayered composite tube, manufacturing method thereof, and application thereof
  • Multilayered composite tube, manufacturing method thereof, and application thereof
  • Multilayered composite tube, manufacturing method thereof, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Component A: PCL500g Component B: PCL500g

[0051] Drug 1: Cilostazol 10g Drug 2: Rapamycin 10g

[0052] Melt 500g of component APCL and 500g of component BPCL on the screw respectively to prepare a melt. While preparing the melt, uniformly add 10g of drug 1 cilostazol to component A, and add 10g of drug 2 rapamycin into B component. The component A PCL melt of completely miscible cilostazol and the component B PCL melt of completely miscible rapamycin were further mixed uniformly through two static filters respectively.

[0053] Component A PCL melt containing cilostazol enters channel A of the distribution plate, and component B PCL melt containing rapamycin enters channel B of the distribution plate.

[0054] The component A PCL melt containing cilostazol and the component B PCL melt containing rapamycin are ejected together from the nozzle H under pressure, and the component containing cilostazol is ejected at the same time The A PCL melt was completely coated in...

Embodiment 2

[0057] Component A: PLGA500g Component B: PLGA500g Component C: PLLA1000g

[0058] Drug 1: Cilostazol 10g Drug 2: Rapamycin 10g

[0059] 500g of Component A PLGA, 500g of Component B PLGA and 1000g of Component C PLLA were respectively added to a sufficient amount of chloroform to prepare a polymer solution. While the solution was being prepared, 10g of drug 1 cilostazol was evenly added to the For component A, add 10 g of drug 2 rapamycin to component B. Component A PLGA solution that is completely miscible with cilostazol, component B PLGA solution that is completely miscible with rapamycin, and component C PLLA solution are further mixed uniformly through three static filters respectively.

[0060] Component A PLGA solution containing cilostazol enters channel A of the distribution plate, component B PLGA solution containing rapamycin enters channel B of the distribution plate, and component C PLLA solution enters channel C of the distribution plate.

[0061] The componen...

Embodiment 3

[0065] Component A: 500g of PLLA+PDLLA mixture Component B: 500g of PLLA+PDLLA mixture

[0066] Component C: PLLA2000g

[0067] Drug 1: Probucol 10g Drug 2: Paclitaxel 10g

[0068] 500g component A PLLA+PDLLA mixture and 500g component B PLLA+PDLLA mixture and 2000g PLLA were melted on the screw respectively to prepare a melt. While the melt was being prepared, 10g of drug 1 probucol was evenly added to component A, Add 10 g of drug 2 paclitaxel to component B. The melt of component A PLLA+PDLLA mixture of probucol completely mixed and the melt of component B PLLA+PDLLA mixture of paclitaxel and the melt of component C PLLA were respectively passed through three

[0069] Static filter for further mixing.

[0070] Component A PLLA+PDLLA mixture melt containing probucol enters channel A of the distribution plate, component B PLLA+PDLLA mixture melt containing paclitaxel enters channel B of the distribution plate, and component C PLLA melt enters channel C of the distribution ...

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Abstract

The invention discloses a multilayered composite tube, a manufacturing method thereof, and a human endoluminal stent manufactured from the tube. The composite tube at least comprises two layers, which are an inner layer component A and an outer layer component B. The tube can also comprise an interlayer component C. At least one of the component A and the component B is a degradable polymer. The component A comprises a medicine component 1. The outer layer component B comprises a medicine component 2. The component C does not comprise medicine. With a fusion or solution method, the components A, B and C are subject to injection molding by using a special distribution plate, such that the composite multilayered tube is formed. The tube is cut or etched, such that hollowed stent is manufactured. Therefore, customization of functional stent aiming at the treatment of different diseased regions can be realized, such that defects of metal stent used in treating angiostegnosis are overcome.

Description

technical field [0001] The invention relates to a multi-layer composite pipe and its manufacturing method and application, more particularly to a human body lumen stent made of the pipe, which belongs to the field of medical devices. Background technique [0002] Interventional medical engineering is an emerging technical discipline that has developed rapidly in recent years. It refers to medical engineering technology that uses a series of interventional devices and materials (or minimally invasive devices and materials) and modern digital diagnosis and treatment equipment for diagnosis and treatment operations. "Minimally invasive, painless, and comfortable" has become the medical concept pursued by people today and the development trend of clinical medicine in the 21st century. Therefore, minimally invasive interventional medicine, as a brand-new surgical method, has grown rapidly at a rapid rate. The scope covers almost cardiovascular, cerebrovascular, cancer, surgery, g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/16B29C45/00
Inventor 葛均波谢建魏征
Owner SHANDONG HUAAN BIOTECH CO LTD
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