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Application of Bacillus licheniformis live bacteria in preparation of medicine for preventing and treating intestinal endotoxemia

A Bacillus licheniformis, endotoxemia technology, applied in antibacterial drugs, pharmaceutical formulations, medical raw materials derived from bacteria, etc. Symptoms, drugs, etc.

Inactive Publication Date: 2012-07-11
NORTHEAST PHARMA SHENYANG SCI & TECH DEV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] So far, there has been no report on the preparation of Bacillus licheniformis for the prevention of acute and chronic enterogenous endotoxemia and the treatment of chronic enterogenous endotoxemia.

Method used

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  • Application of Bacillus licheniformis live bacteria in preparation of medicine for preventing and treating intestinal endotoxemia
  • Application of Bacillus licheniformis live bacteria in preparation of medicine for preventing and treating intestinal endotoxemia
  • Application of Bacillus licheniformis live bacteria in preparation of medicine for preventing and treating intestinal endotoxemia

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Embodiment Construction

[0036] The invention drug animal experimental scheme is as follows.Animal observation object is the acute acute of sulfuridide (TAA), chronic liver injury of enterotoxin ledchenia caused by mice, detection of toxins, serum galcopanosinase (ALT), and serum gyanosanase (AST)The changes in serum propylene (MDA) and serum lactic acid dehydrogenase (LDH) are analyzed and analyzed liver pathology to observe the role of vectorbacteria live bacteria to prevent and therapeutic effects on enterotoxin.

[0037] There are 160 clean-grade SD rats, male, weighing 240-290g, randomly divided into 3 major groups: 40 acute liver injury prevention control groups, 60 chronic liver injury prevention control groups, and 60 chronic liver injury treatment groups.Each large group is randomly divided into 4 groups: normal control group, TAA model group, Liga Live bacteria live bacteria low -dose group, and high -dose group of Lidobacteria living bacteria.The specific experimental scheme is as follows.

[0...

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Abstract

The invention relates to an application of Bacillus licheniformis live bacteria which is applied in the field of biotechnology in preparation of medicine for preventing acute and chronic intestinal endotoxemia and medicine for treating chronic intestinal endotoxemia; an application of the Bacillus licheniformis live bacteria in preparation of medicine for preventing acute and chronic intestinal endoxemia; and an application of the Bacillus licheniformis live bacteria in preparation of medicine for treating chronic intestinal endotoxemia. The intestinal endotoxemia is caused by factor causing damage to liver; a dosage of the Bacillus licheniformis live bacteria is 0.45-1.35 billion live bacteria per kilogram every day. The Bacillus licheniformis live bacteria provided by the invention ameliorates the intestinal endotoxemia caused by acute and chronic liver injury in rat induced by thioacetamide, improves histopathology change of the liver injury of rat, relieves lipid peroxidatic injury of hepatic tissue when chronic liver injury occurs, and partially decreases levels of serum glutamic pyruvic transaminase, glutamic-oxalacetic transaminease and lactic dehydrogenase.

Description

Technical field [0001] The invention involves a new use of a living bacteria in the field of biotechnology as a preparation to prevent acute chronic intestinal endogenous endotoxemia and treat the application of chronic enterotoxemia. Background technique [0002] In 1979, BERG proposed the concept of "bacterial displacement", defining it as "the intestinal living bacteria invaded the intestinal mucosa, such as the infection process of intestinal lymph nodes, liver, spleen, blood, and even the whole body."In 1990, Alexander expanded its content into "microbial displacement", that is, "the intestinal or dead bacteria and its products, including internal toxins, and the process of anatomical intestinal mucosa barrier invaded outside the intestine. 1995 in 1995.Professor Han De Wu from Shanxi Medical University proposed the "theory of enterotoxin ledmia" for the first time in China. It believes that enterological endotoxemia plays a decisive role in the development of liver disease....

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P31/04A61K35/742
Inventor 苏显英顾佩菲刘立新马大中陈铮
Owner NORTHEAST PHARMA SHENYANG SCI & TECH DEV
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