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Application of campsis radicans polysaccharide to preparation of anticoagulant medicines

An anticoagulant technology of Lingxiaohua, which is applied in the application field of the American Lingxiaohua polysaccharide in the preparation of anticoagulant drugs, to achieve the effects of prolonging the bleeding time of the tail tip, inhibiting the formation of fibrin, and prolonging the thrombin time

Inactive Publication Date: 2013-06-12
SUZHOU UNIV
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  • Abstract
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Problems solved by technology

[0005] At the same time, there is no report in the prior art about whether the polysaccharide of Lingxiaohua has anticoagulant effect

Method used

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  • Application of campsis radicans polysaccharide to preparation of anticoagulant medicines

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Experimental program
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Effect test

Embodiment 1

[0018] The medicines and reagents used in this example include: Polysaccharides of Lilyflower americana (content ≥ 50%, measured by ultraviolet spectrophotometry) provided by Soochow University, prepared with 0.5% CMC-Na for animal administration. Aspirin enteric-coated tablets (batch number: H32026500), Nanjing Baijingyu Pharmaceutical Co., Ltd., prepared with 0.5% CMC-Na for animal administration. Prothrombin time (PT) kit (No.: YZB / Shanghai 0556-40-2009), activated partial thromboplastin time (APTT) kit (No.: YZB / Shanghai 0555-40-2009) and thrombin time (TT ) Kit (No.: YZB / Shanghai 0558-40-2009), Shanghai Sun Biological Products Co., Ltd.

[0019] (1) Preparation of polysaccharides from Lilyflower americana:

[0020] 100g of Glycyrrhiza americana, extracted twice with reflux water, the first time with 1500ml water, reflux extraction for two hours; the second time with water 1000ml, reflux extraction for one hour, the extracts were filtered and combined. Concentrate the fi...

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Abstract

The invention relates to application of a campsis radicans polysaccharide, in particular to application of a campsis radicans polysaccharide to the preparation of anticoagulant medicines. The action of the campsis radicans polysaccharide on the blood coagulation time of capillaries and bleeding time of tail tips of mice is measured by intracorporeal administration; and the influence of the campsis radicans polysaccharide on the thrombin time, prothrombin time, active part thromboplastin time and plasma recalcification time of the mice is measured. Anticoagulation experiments indicate that thecampsis radicans polysaccharide can prolong the blood coagulation time of the capillaries and bleeding time of the tail tips of the mice obviously, and prolong the thrombin time, prothrombin time andplasma recalcification time of the mice obviously, and display that the activity of exogenous blood coagulation factors is inhibited, so that the generation of hemaleucin is inhibited, and the thrombin time is prolonged obviously. Experiment results prove that the campsis radicans polysaccharide has an obvious anticoagulation effect.

Description

technical field [0001] The present invention relates to the application of the polysaccharide of the American Lingxiao flower, in particular to the application of the American Lingxiao flower polysaccharide in the preparation of anticoagulant medicine. Background technique [0002] The coagulation system and anticoagulation system in the human body are in a state of dynamic balance, and excessive coagulation can lead to serious diseases such as myocardial infarction and cerebral thrombosis. In the process of thrombus formation, platelet activation and coagulation system activation play an important role. The two are closely related in the body. The thrombin produced after the coagulation system is activated is a powerful platelet activating factor, and the platelet activation will promote the coagulation process. Antithrombotic therapy mainly targets the coagulation system and platelets, which are called anticoagulant therapy and antiplatelet therapy, respectively. At prese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P7/02
Inventor 张健韩海燕姚士褚纯隽孙群吴双庆
Owner SUZHOU UNIV
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