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Method for quick and nondestructive measurement of aldioxa content in aldioxa raw material and preparation

A technology for the content of aluminum allantoin, which is applied in the field of drug analysis, can solve the problems of tedious and time-consuming detection of allantoin aluminum and the detection samples cannot be reused, and achieve accurate and reliable results

Active Publication Date: 2014-08-06
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above current situation of allantoin aluminum analysis technology, the present invention provides a method for rapid and non-destructive determination of allantoin aluminum content in allantoin aluminum and its preparations by near-infrared spectroscopy. Non-destructive analysis, the result is accurate and reliable, the error is less than 5%, which solves the problems of cumbersome and time-consuming detection of allantoin and aluminum, and the detection samples cannot be reused.

Method used

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  • Method for quick and nondestructive measurement of aldioxa content in aldioxa raw material and preparation
  • Method for quick and nondestructive measurement of aldioxa content in aldioxa raw material and preparation
  • Method for quick and nondestructive measurement of aldioxa content in aldioxa raw material and preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Step 1 Collect 15 batches of allantoin aluminum raw materials, and collect 20 samples in each batch. A total of 300 samples are used as modeling samples. There is no need to process the samples and can be directly used as the samples to be tested.

[0034] Step 2 Take about 0.5~3g directly into the quartz sample cup, mix well, flatten gently, and add BaSO 4 As a blank, place it in the integrating sphere sample tank of the near-infrared detector, and obtain the absorption spectrum of aluminum allantoin through near-infrared light scanning. Sample measurement method: integrating sphere diffuse reflection, resolution 8cm -1 , The number of scans is 64, the scan range is 12000-4000cm -1 , Room temperature: 18-25℃, scan each sample 3 times, record the absorption spectrum of each sample in the near-infrared spectral region, select First derivative+Vector normalization for spectral preprocessing (Table 1), and extract characteristic spectrum information. The allantoin aluminum cont...

Embodiment 2

[0042] Step 1 Collect 25 batches of allantoin aluminum tablets, and collect 10 samples in each batch. A total of 250 samples are used as modeling samples. The samples are about 1 to 6 tablets or pellets. The samples are the test objects without processing.

[0043] Step 2 Place the sample directly on the front end of the optical fiber probe and use BaSO 4 As a blank, place it in the integrating sphere sample tank of the near-infrared detector, and obtain the absorption spectrum of aluminum allantoin through near-infrared light scanning. Sample measurement method: integrating sphere diffuse reflection, resolution 8cm -1 , The number of scans is 64, the scan range is 12000-4000cm -1 , Room temperature: 18-25℃, scan each sample 3 times, record the absorption spectrum of each sample in the near-infrared spectral region, select First derivative+Vector normalization for spectral preprocessing (Table 1), and extract characteristic spectrum information. The allantoin aluminum content of th...

Embodiment 3

[0047] Step 1 Collect 20 batches of allantoin aluminum capsules, and collect 15 samples in each batch. A total of 300 samples are used as modeling samples. There is no need to process the samples and can be directly used as samples to be tested.

[0048] Step 2 The capsule sample is about 1 to 6 capsules, and the tip of the optical fiber probe is directly placed with BaSO 4 As a blank, place it in the integrating sphere sample tank of the near-infrared detector, and obtain the absorption spectrum of aluminum allantoin through near-infrared light scanning. Sample measurement method: integrating sphere diffuse reflection, resolution 8cm -1 , The number of scans is 64, and the scan range is 12000-4000cm -1 , Room temperature: 18-25℃, scan each sample 3 times, record the absorption spectrum of each sample in the near-infrared spectral region, select First derivative+Vector normalization for spectral preprocessing (Table 1), and extract characteristic spectrum information. The allantoin...

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Abstract

The invention relates to a method for the quick and nondestructive measurement of an aldioxa content in an aldioxa raw material and a preparation. The method comprises the following steps of: 1, taking a sample including aldioxa; 2, scanning the sample including the aldioxa by using a near infrared spectrometer; and 3, calculating the aldioxa content in the sample according to a spectrogram obtained by the scanning. The method has the advantages that the pretreatment of the sample is simple, the detection is quick and nondestructive, the production efficiency is improved, and the method is a big innovation for the content measurement of the aldioxa and the preparation thereof and has bigger economic benefit and social benefit.

Description

1. Technical Field [0001] The invention belongs to the technical field of medicine analysis, and particularly relates to a method for quickly and non-destructively determining the content of allantoin aluminum in allantoin aluminum and its preparations by near infrared spectroscopy. 2. Background technology [0002] Aluminum allantoin was synthesized in 1956. In 1962, French R.cachen et al. found that it has a good anti-ulcer effect. After a large number of basic pharmacological research and clinical trials, since the drug was launched in Japan in the 1970s, more than 20 manufacturers have applied for production. Currently, there are multiple dosage forms such as tablets, powders, and granules. This product is included in the Twelfth Edition of the Japanese Pharmacopoeia (pharmacopoeia). This product has a history of more than 20 years in foreign markets, enduring for a long time, and has been widely used in clinical practice. It has achieved good results in the treatment of ga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359
Inventor 杨春艳
Owner WUXI JIYU SHANHE PHARM CO LTD
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