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Pantoprazole sodium medicine compound and preparation technology thereof

A technology of pantoprazole sodium and its composition, applied in the treatment of gastric ulcer, in the field of compound medicine, can solve the problems of insignificant therapeutic effect, large toxic and side effects, easy rebound, etc., achieve good therapeutic effect, quick effect, The effect that is not easy to relapse

Active Publication Date: 2012-07-04
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the problem of the treatment of gastric ulcer, overcome the problems that the Western medicine pantoprazole sodium is easy to rebound, has large toxic and side effects, and the treatment effect is not significant, and achieves the purpose of treating both symptoms and root causes

Method used

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  • Pantoprazole sodium medicine compound and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A compound pantoprazole sodium pharmaceutical composition is characterized in that it is prepared by following weight ratio raw materials,

[0027] 0.5 parts of pantoprazole sodium, 35 parts of astragalus, 27 parts of magnolia bark, 18 parts of pinellia, 15 parts of curcuma

[0028] The above-mentioned compound pantoprazole sodium pharmaceutical composition preparation method is: get pantoprazole sodium 0.5g, astragalus 35g, Magnolia officinalis 27g, pinellia 18g, curcuma 15g and make capsule through pulverizing by conventional method, every 0.5g, After passing the inspection, it is a finished product.

[0029] Acute Toxicity Study

[0030] Healthy rats and mice were given the Chinese and Western medicine compound pantoprazole sodium pharmaceutical preparation for the treatment of gastric ulcer of the present invention through single oral gavage respectively, and the gavage dose was 100 times of the planned clinical dosage. After the administration, the mice showed a ...

Embodiment 2

[0036] 1. Clinical data

[0037] 90 cases of gastric ulcer patients with complete clinical data were randomly divided into treatment group and control group, 50 cases in the treatment group, 21 cases were male, 29 cases were female, aged 18-60 years old, average age 39 years old, course of disease 2 months-8 year. Control group 40 cases, male 20 cases, female 20 cases, age is 21-58 years old, average age is 37 years old, course of disease 1 month-7 years, there is no significant difference in gender, age, course of disease etc. before two groups of cases are treated ( P>0.05), comparable.

[0038] 2. Diagnostic criteria

[0039] With reference to the "Guiding Principles for Clinical Research of Digestive System Drugs" promulgated by the Ministry of Health in 1993, stomach heat syndrome: burning pain in the epigastric cavity, thirsty mouth, cold drinks, and acid regurgitation. Swollen and painful gums, dry stool, yellow urine, red tongue with yellow coating. Stomach Cold Sy...

Embodiment 3

[0066] typical embodiment

[0067] Zhao, female, 45 years old, has been suffering from epigastric pain for more than three years, especially at night and before meals, dark stool, barium meal examination, gastric ulcer, pain in the epigastric cavity when visiting the doctor, after eating The onset occurred in about 1 hour, accompanied by belching, acid regurgitation, noisy discomfort, irritability, uncomfortable stool, red tongue with yellow coating, and rapid pulse. Combined with gastroscopic examination, it was found that the gastric wall tissue defect was found in the fundus of the stomach, forming a depression, an ulcer with a diameter of about 10mm, covered with white coating on the surface, hyperemia and edema around the ulcer, showing obvious inflammation. A diagnosis of gastric ulcer was made. Take the compound pantoprazole sodium pharmaceutical composition preparation that embodiment 1 prepares, every day three times, each two, take before three meals.

[0068] Afte...

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Abstract

The invention relates to a pantoprazole sodium medicine compound and a preparation technology thereof. The pantoprazole sodium medicine compound is prepared by taking the following raw materials by weight part: 0.5 parts of pantoprazole sodium, 35 parts of astragalus mongholicus, 27 parts of mangnolia officinalis, 18 parts of pinellia ternata and 15 parts of curcuma zedoary. According to the traditional medicine preparation method, after pharmaceutic adjuvants, such as starch or edible cellulose, are added, the medicine is prepared into capsules, tablets, grains, and the like. The pantoprazole sodium medicine compound provided by the invention has the function of treating both principal and secondary aspects of gastric ulcer, is non-toxic and harmless to human body, is free from side effect, is low in cost, is conveniently prepared and is wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese and western medicine preparation for treating gastric ulcer, in particular to the application of a compound medicine made of western medicine pantoprazole sodium and Chinese herbal medicine in treating gastric ulcer. Background technique [0002] Gastric ulcer is one of the common diseases of the digestive system. In recent years, with the acceleration of the pace of life and irregular diet, the incidence rate has increased. The main symptoms are often recurrent rhythmic upper abdominal pain or chronic arrhythmic upper abdominal pain, often accompanied by acid reflux, fullness, belching, burning, noisy, etc., and even nausea, vomiting, hematemesis, blood in the stool, etc., a few can develop to gastric cancer, seriously threatening the lives of patients. The main pathogenic factors of gastric ulcer are: ① Helicobacter pylori (Hp): Hp is a kind of digestive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/04A61K31/4439
Inventor 赵振桥聂昌盛张玉美徐平田王丽娟杜宾芳
Owner 仁和堂药业有限公司
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