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Benazepril hydrochloride tablets for cats and dogs and preparation method for benazepril hydrochloride tablets

A technology of benazepril hydrochloride tablets and magnesium stearate, which is applied in the field of medicine, can solve the problems of active drug degradation and other problems, and achieve the effects of small side effects, rapid onset of action, and good palatability

Inactive Publication Date: 2012-07-04
NANJING SBEED BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found through research that through dry granulation, the problem of sticking and punching is more serious, while using traditional wet granulation, due to the need for wet heating process, the active drug will be degraded during the contact between benazepril and water

Method used

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  • Benazepril hydrochloride tablets for cats and dogs and preparation method for benazepril hydrochloride tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This embodiment provides a benazepril hydrochloride tablet for cats and dogs, which includes main ingredients and auxiliary materials, and is characterized in that it is prepared according to the following mass percentages: main ingredients 0.1-2%, auxiliary materials 98.0%-99.0%. Concrete component mass percent is as follows:

[0042] The main ingredient accounts for the mass percentage of the whole benazepril hydrochloride tablets for cats and dogs: benazepril: 0.1-2%.

[0043] Each component accounts for the mass percent of whole benazepril hydrochloride tablet for cats and dogs in the auxiliary material as follows:

[0044] Lactose: 30-70%; microcrystalline cellulose: 10-50%; hydroxypropyl cellulose: 0.5-10%; cross-linked polyvinylpyrrolidone: 0.5-9%; polyvinylpyrrolidone K30: 1-10 %; Aspartame: 0.1-1%; Magnesium stearate: 0.2-1.5%.

[0045] The present inventors found that Benazepril is a new generation of powerful and long-acting ACE inhibitor of hydroxyl group,...

Embodiment 2

[0062] The benazepril hydrochloride tablets for cats and dogs provided in this example, including main ingredients and auxiliary materials, are formulated according to the following mass percentages: main ingredient 0.8%, auxiliary materials 99.2%.

[0063] Specifically, the benazepril hydrochloride tablet of the present embodiment is formulated from the raw materials of the following mass ratio:

[0064] Benazepril 0.8%; Lactose 58.8%; Microcrystalline Cellulose 27.9%; Hypromellose 4.0%; Crosslinked PVP 3.0%; A total of 1500 tablets were produced.

[0065] The preparation method of benazepril hydrochloride tablets for cats and dogs provided in this example mainly includes the steps of weighing and mixing raw materials and tableting. The specific process steps are as follows (ingredients are in accordance with the above-mentioned mass ratio):

[0066] (1) Take lactose, microcrystalline cellulose, and hydroxypropyl cellulose and mix them in a mixer for 30 minutes.

[0067] (2...

Embodiment 3

[0073] The benazepril hydrochloride tablets for cats and dogs provided in this example include main ingredients and auxiliary materials, and are characterized in that they are prepared according to the following mass percentages: main ingredient 0.76%, auxiliary materials 99.24%. The benazepril hydrochloride tablet for cats and dogs of the embodiment of the present invention is formulated from the raw materials of the following mass ratio:

[0074] Benazepril 0.76%; Lactose 60.2%; Microcrystalline Cellulose 26.2%; Hypromellose 4.3%; Cross-linked PVP 2.8%; A total of 1500 tablets were produced.

[0075] The preparation method of benazepril hydrochloride tablet of the present invention comprises raw material weighing and mixing, tabletting operation, is characterized in that concrete process step is as follows:

[0076] (1) Take lactose, microcrystalline cellulose, and hydroxypropyl cellulose and mix them in a mixer for 30 minutes.

[0077] (2) Take benazepril and mix it with ...

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Abstract

The invention discloses benazepril hydrochloride tablets for cats and dogs and a preparation method for the benazepril hydrochloride tablets. The benazepril hydrochloride tablets consist of the following components in percentage by mass: 0.1 to 2 percent of benazepril, 30 to 70 percent of lactose, 10 to 50 percent of microcrystalline cellulose, 0.5 to 10 percent of hydroxypropyl cellulose, 0.5 to 9 percent of cross-linked polyvinylpyrrolidone, 1 to 10 percent of polyvinylpyrrolidone K30, 0.1 to 1 percent of aspartame and 0.2 to 1.5 percent of magnesium stearate. After being taken, the tablets can be quickly disintegrated, and active ingredients can be quickly dissolved; and the tablets have high palatability, and small irritation on intestines and stomach.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a benazepril hydrochloride tablet for cats and dogs and a preparation method thereof. Background technique [0002] Heart disease in pets, especially dogs and cats, is not uncommon in small animal clinics. With the increasing number of elderly dogs and cats, the incidence of heart disease is on the rise, but the diagnostic techniques and treatment methods are still relatively backward. [0003] At present, drugs commonly used in the treatment of heart disease include renin-angiotensin-aldosterone system blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB) and aldosterone Receptor antagonists, sympathetic blockers, etc. ACEI is widely used in human medicine, and the effect is more significant. However, in veterinary clinics, there is no product specifically for dogs and cats, and most of them are used for human medicine. It is illegal to tra...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/55A61K47/38A61P9/04A61P9/10A61P9/12
Inventor 高国峰
Owner NANJING SBEED BIOTECH
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