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Preparation method for silicon compound of Equisetum

A technology of silicide and fenugreek, applied in the field of natural medicinal chemistry, can solve the problem of low purity of fenugreek silicide, and achieve the effects of easy industrial production, simple method operation, and improved product purity.

Inactive Publication Date: 2012-06-27
江苏博益生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, these existing methods are all simple crude extraction, and the purity of the obtained silicide is relatively low, and the content of organic silicic acid is mostly about 10%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Remove impurities and wash fresh twigs, take 10kg for beating, add 50kg of appropriate amount of warm water to soak, extract the supernatant, filter and add to 3LD101 macroporous resin column, collect the next column liquid, then take 3BV water washing resin column, eluent and lower The column liquids were combined, molecular interception was carried out with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 2000, and an appropriate amount of water was added for dialysis, and the filtrate was concentrated with a hollow cellulose nanofiltration membrane with a molecular weight cut-off of 100, and the concentrated solution was spray-dried to obtain a light yellow 340g of powder, detected by spectrophotometry, has a content of 64%.

Embodiment 2

[0015] Remove impurities and wash fresh thorns, take 10kg for beating, add 60kg of appropriate amount of warm water to soak, extract the supernatant, filter it, add it to a 4L AB-8 macroporous resin column, collect the next column liquid, then take 3BV of water to wash the resin column, and elute The liquid and the lower column liquid are combined, molecular interception is carried out with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 6000, and an appropriate amount of water is added for dialysis, and the filtrate is concentrated with a hollow cellulose nanofiltration membrane with a molecular weight cut-off of 200, and the concentrated solution is spray-dried. Obtain 448g of light yellow powder, detected by spectrophotometry, the content is 85%.

Embodiment 3

[0017] Remove impurities and wash fresh thorns, take 10kg for beating, add 70kg of appropriate amount of warm water to soak, extract the supernatant, filter and add to 5L HPD100 macroporous resin column, collect the next column liquid, then take 4BV water sinking resin column, eluent Combine with the lower column liquid, carry out molecular interception with a hollow cellulose ultrafiltration membrane with a molecular weight cut-off of 3000, add an appropriate amount of water for dialysis, concentrate the filtrate with a hollow cellulose nanofiltration membrane with a molecular weight cut-off of 100, and spray-dry the concentrated solution to obtain Light yellow powder 380g, detected by spectrophotometry, the content is 78%.

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PUM

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Abstract

The invention discloses a preparation method for a silicon compound of Equisetum. The method comprises the following steps: with fresh Equisetum arvense as a raw material, carrying out impurity removal, cleaning and beating, soaking obtained slurry with a proper amount of warm water, extracting supernatant, allowing the supernatant to pass through a macroporous resin column after filtration, eluting the resin column with water, merging eluent and column-passing liquid, filtering obtained mixed liquid with an ultrafiltration membrane, condensing obtained filtrate with a nanofiltration membrane and carrying out spray drying on obtained condensate so as to obtain the silicon compound of Equisetum. The method provided in the invention has the advantages of simple operation and low energy consumption, enables the content a prepared product to be high and is easy for industrial popularization.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to a preparation method of silicide. Background technique [0002] It is the whole herb of Equisetum arvense L., which is a plant of the genus Equisetaceae Equisetum. "Supplements to Materia Medica", "Pharmacology of Traditional Chinese Medicine", "New Edition of Traditional Chinese Medicine", "Sichuan Traditional Chinese Medicine" and "Shaanxi Chinese Herbal Medicine" all have records. Most of the treatises believe that Qujing has the effects of clearing away heat, diuresis, hemostasis, and detumescence. Mainly treat urinary tract infection, painful urination, bone fracture, epistaxis, hemoptysis, intestinal bleeding, menorrhagia and other diseases. Modern studies have shown that quince contains flavonoids, alkaloids, organic acids and silicides, among which silicides are high in quince. Pharmacological tests have found that silicide has the functions of prot...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P1/16A61P3/06A61P7/10A61P9/12
Inventor 陈洪生程志鹏
Owner 江苏博益生物科技有限公司
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