Doxofylline freeze-dried powder injection

Abstract

The invention relates to a freeze-dried powder injection, in particular to a doxofylline freeze-dried powder injection. The injection is characterized by being prepared according to the following preparation method: adding 200 g of doxofylline and 150 g of mannitol into a container with scales; adding injection water to 4,800 ml; stirring while adding; adding 4.8 g of active carbon according to a standard that 1 mg of active carbon is added per 1 ml of solution; stirring and adsorbing for 30 minutes; decarburizing; adjusting pH value to be 4.5-6.5 by using 0.01 mol / L hydrochloric acid solution; adding injection water to 6,000 ml; removing bacteria and filtering; then filling in the amount of 5.8-6.3 ml per bottle; and finally, placing the filled injection into a freeze-dryer to freeze-dry, pressing a plug after the freeze-drying is finished, and capping to obtain the freeze-dried powder injection. The freeze-dried powder injection has the advantages that: the process is adjusted scientifically and rationally, so that the allocation quantity filled in a penicillin bottle before freeze-drying is about 6 ml; and therefore, the freeze-dry evaporation energy consumption is reduced, and the production cost is reduced.

Description

technical field [0001] The invention relates to a freeze-dried powder injection, in particular to a doxofylline freeze-dried powder injection. Background technique [0002] In the current preparation process of doxofylline freeze-dried powder injection, due to the poor water solubility of doxofylline, the original configuration process does not coordinate the dissolution temperature and dissolution pH, and can only combine doxofylline and doxofylline at most. The concentration of the auxiliary material is prepared at 0.038-0.042g / ml, which increases the filling volume, slows down the sublimation speed of water in the freeze-drying process, and increases energy consumption. Contents of the invention [0003] The object of the present invention is to provide a doxofylline freeze-dried powder injection, which can increase the concentration of doxofylline and its auxiliary materials and reduce the filling volume, thereby accelerating the sublimation speed of water in the freez...

AI Technical Summary

Problems solved by technology

[0002] In the current preparation process of doxofylline freeze-dried powder injection, due to the poor water solubility of doxofylline, the original configuration process does not coordinate the dissolution temperature and dissolution pH, and can only combine doxofylline and doxofylline at most. The concentration of its excipients is prepared at 0.038-0.042g / ml, which increases the filling volume, slows down the sublimation rate of water in the freeze-drying process, and increases energy consumption

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