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Co-containing sandwich heteropolyacid as well as synthesis method and application thereof

A synthesis method and technology of heteropolyacids, applied in cobalt compounds, chemical instruments and methods, drug combinations, etc., can solve the problems that polyoxometalates have not yet been developed, and research has not been reported.

Inactive Publication Date: 2012-06-20
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Scholars at home and abroad have explored polyoxometalates against colorectal tumors, such as in 1992, Na[IMo 6 o 24 ] As an anti-colorectal cancer drug, it has been clinically used in Japan, but polyoxometalates have not yet been used as colorectal tumor chemotherapy drugs, especially the research of polyoxometalates based on transition metal cobalt in anti-colorectal tumors has not yet been carried out. see the report

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  • Co-containing sandwich heteropolyacid as well as synthesis method and application thereof
  • Co-containing sandwich heteropolyacid as well as synthesis method and application thereof
  • Co-containing sandwich heteropolyacid as well as synthesis method and application thereof

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specific Embodiment approach 1

[0011] Specific embodiment one: the molecular formula of the cobalt-containing sandwich heteropolyacid of the present embodiment is H 6 [Bi 2 W 20 co 2 (OH 2 ) 6 o 70 Na 4 (OH 2 ) 14 ](C 3 h 4 N 2 ) 2 .

[0012] H in this embodiment 6 [Bi 2 W 20 co 2 (OH 2 ) 6 o 70 Na 4 (OH 2 ) 14 ](C 3 h 4 N 2 ) 2It is pink powder crystal. H in this embodiment 6 [Bi 2 W 20 co 2 (OH 2 ) 6 o 70 Na 4 (OH 2 ) 14 ](C 3 h 4 N 2 ) 2 The growth inhibitory effect of the compound on human colon cancer HT-29 tumor cells was detected by thiazolium blue (MTT) method, and its half inhibitory concentration IC 50 =0.11 mmol / L, 24h. Fluorescent staining methods such as Hoechst 33342 and AO / EB detect the cobalt-containing sandwich heteropolyacid H in the present embodiment. 6 [Bi 2 W 20 co 2 (OH 2 ) 6 o 70 Na 4 (OH 2 ) 14 ](C 3 h 4 N 2 ) 2 It has apoptosis-inducing effect on human colon tumor cell lines. Adopt the agarose gel electrophoresis (DNAladder) ...

specific Embodiment approach 2

[0013] Specific embodiment two: the synthetic method of the cobalt-containing sandwich heteropolyacid of the present embodiment is carried out according to the following steps: one, under magnetic stirring, the Na of 4mmol~5mmol 2 WO 4 Dissolve in 80mL-120mL deionized water, and heat to 80°C-120°C, then add hydrochloric acid with a concentration of 6mol / L dropwise to adjust the pH to 5.0-7.0 to obtain solution A; 2. Mix 0.3mmol-0.8mmol of Bi(NO 3 ) 3 Dissolved in 10 mL of hydrochloric acid with a concentration of 6 mol / L, Bi(NO 3 ) 3 solution, and Bi(NO 3 ) 3 Solution, 0.5mmol ~ 1mmol CoCl 2 Add 0.8mmol ~ 1.2mmol imidazole to the solution A obtained in step 1 and mix evenly, heat to 80°C ~ 120°C and keep it for 1h ~ 2h under stirring condition, then cool to room temperature, after filtering, the filtrate is still for 5 After ~10 days, crystals were precipitated to obtain a cobalt-containing sandwich heteropolyacid.

specific Embodiment approach 3

[0014] Specific embodiment three: the difference between this embodiment and specific embodiment two is that in step one, 4.2mmol~4.8mmol of Na 2 WO 4 Dissolve in 90mL~110mL deionized water, and heat to 90℃~110℃. Other steps and parameters are the same as in the second embodiment.

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Abstract

The invention discloses Co-containing sandwich heteropolyacid as well as a synthesis method and application thereof, relating to heteropolyacid as well as synthesis method and application thereof. The invention provides a novel chemotherapy drug capable of resisting human colorectal adenocarcinoma and a synthesis method thereof. The molecular formula of the Co-containing sandwich heteropolyacid provided by the invention is H6[Bi2W20Co2(OH2)6O70Na4(OH2)14](C3H4N2)2. The synthesis method is as follow: firstly, dissolving Na2WO4 into water, heating and adjusting the pH value to obtain solution A; secondly, dissolving Bi(NO3)3, CoC12 and imidazole into the solution A at the same time to be uniformly mixed; heating to 80-120 DEG C and maintaining the temperature for 1-2h; and cooling, filtering and standing to obtain Co-containing sandwich heteropolyacid. The Co-containing sandwich heteropolyacid has the action of restraining the growth of cancer cells and the action of inducing death of the cancer cells. Therefore, the Co-containing sandwich heteropolyacid can be used as a chemotherapy drug for treatment of human colorectal adenocarcinoma.

Description

technical field [0001] The invention relates to a sandwich heteropolyacid and its synthesis method and application. Background technique [0002] Colorectal cancer is the third most common visceral malignancy and one of the leading causes of cancer-related death due to treatment resistance in the world. The main treatment methods received by patients are palliative surgery and chemotherapy. Chemotherapy has become the most important method of clinical tumor treatment. Chemotherapy drugs in clinical practice and experimental research stage mainly include synthetic compounds and natural product extracts or phytochemicals, but synthetic compounds are the first choice and have obvious effects. For example, in 2000, the main clinical chemotherapy drugs for colorectal malignant tumors were 5 - Fluorouracil conjugated with leucovorin. In order to further increase the survival rate of patients with colorectal malignant tumors, the development of highly efficient chemotherapy synt...

Claims

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Application Information

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IPC IPC(8): C07D233/58C01G51/00A61K33/24A61P35/00
Inventor 王路周百斌于凯苏占华王春晓初丽丽吴江山祁
Owner HARBIN INST OF TECH
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