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Preparation method for Chinese medicinal Chinese thorowax root injection

A technique for Bupleurum injection and traditional Chinese medicine, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as unstable quality and poor clarity.

Inactive Publication Date: 2012-05-23
裘建社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Bupleurum Injection mainly has the problems of poor clarity and unstable quality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Weigh 1000g of Radix Bupleurum, clean it, wash it, and soak it in purified water. Add 4000ml of purified water, boil, distill, collect 2000ml of the initial distillate, and then redistill, collect about 800ml of the double distillate, filter to obtain the Bupleurum double distillate; take an appropriate amount of water for injection, add polysorbate 80, stir to dissolve, Then add sodium chloride, add Bupleurum double distillate, stir evenly, adjust the pH value to 5.5 with 20% disodium hydrogen phosphate solution, add water for injection to 1000ml, stir for 5 minutes, filter through 0.45μm and 0.22μm, and potting , sterilized at 105°C for 30 minutes, inspected by light, and packaged.

Embodiment 2

[0011] Weigh 10kg of Bupleurum bupleuri, clean it, wash it, and soak it in purified water. Add 40,000 ml of purified water, boil, distill, collect 20,000 ml of the initial distillate, and then redistill, collect about 8,000 ml of the double distillate, filter to obtain the Bupleurum double distillate; take an appropriate amount of water for injection, add polysorbate Ester 80, stir to dissolve, then add sodium chloride, add Bupleurum double distillate, stir evenly, adjust the pH value to 5.8 with 10% concentrated ammonia solution, add water for injection to 10,000 ml, stir for 5 minutes, and pass through 0.45 μm, Filter at 0.22 μm, potting, sterilize at 105°C for 30 minutes, light inspection, and packaging.

Embodiment 3

[0013] Weigh 700kg of Radix Bupleurum, clean it, wash it, and soak it in purified water. Add 2.8 million ml of purified water, boil, distill, collect 1.4 million ml of initial distillate, and then redistill, collect about 560,000 ml of double distillate, filter to obtain Bupleurum double distillate; take appropriate amount of water for injection, add polysorbate Ester 80, stir to dissolve, then add sodium chloride, add Bupleurum double distillate, stir evenly, adjust the pH value to 5.8 with 10% concentrated ammonia solution, add water for injection to 700,000 ml, stir for 5 minutes, and pass through 0.45 μm, Filter at 0.22 μm, potting, sterilize at 105°C for 30 minutes, light inspection, and packaging.

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PUM

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Abstract

The invention relates to a preparation method for a Chinese medicinal Chinese thorowax root injection. The preparation method disclosed by the invention comprises the following steps of: distilling Chinese thorowax root with water steam; collecting a primary distillate; redistilling; collecting a redistillate; adding polysorbate 80 and sodium chloride; mixing uniformly; adjusting the pH value to 4.0-7.0 with a pH adjusting agent; uniformly stirring; filtering with filter cores of 0.45 mum and 0.22 mum, and encapsulating; sterilizing at the temperature of 105 DEG C for 30 minutes; performing light inspection; and packing to obtain the Chinese thorowax root injection. The Chinese thorowax root injection has the effects of clearing heat and relieving exterior syndrome, and has remarkable clinical curative effects on fever caused by cold, influenza, malaria and the like.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine Bupleurum bupleuri preparation, in particular to a preparation method of a traditional Chinese medicine Bupleurum bupleurum injection. Background technique [0002] Bupleurum is a commonly used traditional Chinese medicine, listed as top grade in "Shen Nong's Materia Medica", and it is the dried root of Bupleurum chinese DC or Bupleurum scor zonerifolium Willd. Bitter in the mouth, slightly cold in nature. It is mainly produced in Hebei, Henan, Liaoning, Hubei, Shaanxi and other provinces. It has the effects of reconciling the exterior and interior, soothing the liver, and promoting yang. It is used for colds and fever, alternating cold and heat, chest and rib pain, irregular menstruation, uterine prolapse, and anal prolapse. Treatment. Bupleurum injection is a traditional Chinese medicine injection made by steam distillation of Bupleurum bupleuri. The active ingredient i...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/08A61K47/02A61K47/04A61P1/00A61P15/00A61P29/00
CPCY02A50/30
Inventor 裘建社何国增曾德智
Owner 裘建社
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