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Application of sunset abelmoschus flower total flavone to preparation of medicament for preventing and treating hepatofibrosis

A technology of liver fibrosis and hollyhock flower, which is applied to the application field of total flavonoids of hollyhock flower in the preparation of medicine for preventing and treating liver fibrosis

Inactive Publication Date: 2012-05-23
陈志武 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing commercially available preparations of hollyhock flowers include huangkui capsules, which are used to treat nephritis. Studies have also shown that the total flavonoids of hollyhock flowers can treat oral ulcers and cardiovascular and cerebrovascular diseases, and have protective effects on ischemic and hypoxic brain damage; and The research and development of this drug for the role of liver fibrosis has not yet

Method used

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  • Application of sunset abelmoschus flower total flavone to preparation of medicament for preventing and treating hepatofibrosis
  • Application of sunset abelmoschus flower total flavone to preparation of medicament for preventing and treating hepatofibrosis
  • Application of sunset abelmoschus flower total flavone to preparation of medicament for preventing and treating hepatofibrosis

Examples

Experimental program
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Embodiment Construction

[0088] Get 10Kg of hollyhock peanut medicinal powder, add 10 times the amount of 100L70% ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, let cool, filter, recover ethanol under reduced pressure until there is no alcohol smell, and concentrate to a relative density of 1.3 (70°C) extract. Add boiling water equivalent to 6 times the amount of the crude drug, stir to dissolve, filter, add the filtrate to the treated polyamide column (14-30 mesh, equivalent to 7 times the amount of the crude drug), and elute with water until the effluent is light yellow. , eluted with 70% ethanol, collected the eluted ethanol until the eluate was pale yellow, recovered the ethanol under reduced pressure, dried under reduced pressure at 80°C to a dry extract, and pulverized to obtain the total flavonoids of marshmallow flowers.

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Abstract

The invention relates to application of sunset abelmoschus flower total flavone, and particularly relates to application of the sunset abelmoschus flower total flavone to a medicament for preventing and treating hepatofibrosis. The sunset abelmoschus flower total flavone is an effective part extracted from a medicinal material, namely a sunset abelmoschus flower. Animal experiments show that the sunset abelmoschus flower total flavone has a protective action on carbon tetrachloride-induced acute hepatic injury of a mouse; and a model of rat hepatofibrosis induced by carbon tetrachloride and swine serum proves that the sunset abelmoschus flower total flavone has a better prevention and treatment action on chronic hepatofibrosis. The results show that the sunset abelmoschus flower total flavone has a definite action of resisting fibrosis, thereby being capable of being used for preparing the medicament for preventing and treating the hepatofibrosis.

Description

Technical field: [0001] The invention relates to the application of the total flavonoids of hollyhock flowers, in particular to the application of the total flavonoids of hollyhock flowers in medicines for preventing and treating liver fibrosis. Background technique: [0002] Hollyhock flower is the dried flower of Malvaceae plant Abelmoschus manihot L.Medic, recorded in "Chinese Pharmacopoeia" (2010 edition), its main components are hyperin, quercetin-3'-glucoside, isoquercetin Flavonoids such as dermatidine, gossycetin-3′-glucoside, quercetin and myricetin are used in the folk to treat boils, mumps, urinary tract infection, lung heat cough and burns. The existing commercially available preparations of hollyhock flowers include huangkui capsules, which are used to treat nephritis. Studies have also shown that the total flavonoids of hollyhock flowers can treat oral ulcers and cardiovascular and cerebrovascular diseases, and have protective effects on ischemic and hypoxic br...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61K133/00
Inventor 陈志武杜安全周正华方明
Owner 陈志武
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