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Compound albendazole suspension containing ivermectin nanoemulsion and preparation method thereof

A technology of albendazole and ivermectin, which is applied in the direction of medical preparations containing active ingredients, emulsion delivery, liquid delivery, etc., can solve problems such as poisoning, uneven drug dispersion, and affecting therapeutic effects, and reduce cost, enhanced bioavailability, effect of prolonged residence time

Active Publication Date: 2012-05-09
HUBEI WUDANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For this reason, someone prepared albendazole and abamectin (the similar product of ivermectin) into a compound preparation, such as the Chinese patent application number 98113660.5-compound probendazole milk for expelling internal and external parasites of livestock and its preparation The method is to suspend albendazole (that is, albendazole) in liquid paraffin, form an 0 / W emulsion with water under the action of an emulsifier, dissolve abamectin in propylene glycol, and then dissolve it in water , but because avermectin is insoluble in water, although it is dissolved in this medicine with the help of propylene glycol, the whole crystal of abamectin will precipitate and precipitate when it meets water, resulting in uneven dispersion of the medicine, affecting the therapeutic effect, and even causing poisoning

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The albendazole suspension containing ivermectin nanoemulsion, its formula is respectively by weight: ingredient drug: 2.5 parts of albendazole, 0.08 part of ivermectin, oil item: glyceryl triacetate 3 Parts, co-surfactant: 5 parts of ethanol, dispersant: 5 parts of Tween-60, suspending agent: 0.12 part of dextran-70, thickener: 0.32 part of xanthan gum, preservative: 0.1 part of benzoic acid, benzene 0.25 parts of sodium formate.

[0025] The preparation method of the albendazole suspension containing ivermectin nanoemulsion, its concrete process is as follows:

[0026] 1. Take 0.08g of ivermectin and add 3g of ethanol, heat to 40°C, stir to dissolve, add 3g of glycerol triacetate, stir evenly, add 5g of Tween-60, stir evenly, set aside.

[0027] 2. Take 2.5g of albendazole and add it to item 1, stir it into a paste, moisten it, and set aside.

[0028] 3. Take 2g of ethanol and add 0.32g of xanthan gum to moisten it, set aside.

[0029] 4. Take 0.12g of dextra...

Embodiment 2

[0032] Containing the albendazole suspension of ivermectin nanoemulsion, its formula is respectively by weight: ingredient drug: 5 parts of albendazole, 0.16 part of ivermectin, oil item: 6 parts of ethyl acetate , co-surfactant: 1, 8 parts of propylene glycol, dispersant: 8 parts of Pingpingjia A-20, suspending agent: 0.1 part of dextran-20, thickener: 0.35 parts of peach gum, preservative: 0.25 parts of citric acid , 0.45 parts of sodium citrate.

[0033] The preparation method of the albendazole suspension containing ivermectin nanoemulsion, its concrete process is as follows:

[0034] 1. Take 0.16g of ivermectin and add 5g of 1,2 propylene glycol, heat to 40°C, stir to dissolve, add 6g of ethyl acetate, stir evenly, add 8g of hot-melted Pingpingjia A-20, stir evenly, and set aside.

[0035] 2. Take 5g of albendazole and add it to item 1, stir it into a paste, moisten it, and set aside.

[0036] 3. Take 3g of 1,2 propylene glycol and add 0.35g of peach gum to moisten...

Embodiment 3

[0040] Containing the albendazole suspension of ivermectin nanoemulsion, its formula is respectively by weight: ingredient drug: 7.5 parts of albendazole, 0.2 part of ivermectin, oil item: glyceryl triacetate 3 Parts, co-surfactant: 5 parts of ethanol, dispersant: 5 parts of Tween-60, suspending agent: 0.12 part of dextran-70, thickener: 0.28 part of xanthan gum, preservative: 0.1 part of benzoic acid, benzene 0.25 parts of sodium formate.

[0041] The preparation method of the albendazole suspension containing ivermectin nanoemulsion, its concrete process is as follows:

[0042] 1. Take 0.2g of ivermectin and add 4g of ethanol, heat to 40°C, stir to dissolve, add 3g of glycerol triacetate, stir evenly, add 5g of Tween-60, stir evenly, set aside.

[0043] 2. Take 7.5g of albendazole and add it to item 1, stir it into a paste, moisten it, and set aside.

[0044] 3. Take 1g of ethanol and add 0.28g of xanthan gum to moisten it, set aside.

[0045] 4. Take 0.12g of dextran-7...

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PUM

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Abstract

The invention relates to an albendazole suspension containing ivermectin nanoemulsion, which is characterized by comprising the following components in parts by weight: 1-30 parts of albendazole, 0.01-1 part of ivermectin, 1-10 parts of oil phase, 1-20 parts of cosurfactant, 1-25 parts of dispersant (emulsifier), 0.01-10 parts of suspending agent, 0.01-10 parts of thickening agent and 0.1-10 parts of preservative. The invention ingeniously uses the oil phase of the ivermectin nanoemulsion as a wetting agent for wetting albendazole, thereby reducing the consumption of the surfactant and solvent, enhancing the safety of the preparation and greatly lowering the cost of the preparation.

Description

technical field [0001] The invention belongs to the field of preparation of veterinary medicine preparations, and relates to a medicine for treating internal and external parasitic diseases of livestock, an albendazole suspension containing ivermectin nanoemulsion and a preparation method thereof. Background technique [0002] The deworming effects of Albendazole and Ivermectin have been fully affirmed by the industry after years of clinical application. However, since the anthelmintic spectrum of these two drugs has its own emphasis, this brings a lot of inconvenience to the clinical application of veterinary medicine. For example, albendazole has a wide deworming spectrum for endoparasites in animals, but is ineffective for ectoparasites. Ivermectin has a wide deworming spectrum against ectoparasites, and is also effective against some internal parasites (mainly nematodes), but it is ineffective against tapeworms and trematodes. [0003] For this reason, someone prepared...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4184A61K9/10A61P33/00A61P33/14
Inventor 郑国祥
Owner HUBEI WUDANG ANIMAL PHARMA
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