Chinese medicinal composition for resisting hepatic fibrosis and preparation method and use thereof

Abstract

The invention discloses a Chinese medicinal composition for resisting hepatic fibrosis and a preparation method and use thereof. The Chinese medicinal composition is prepared from the following Chinese medicinal materials: herb of virgate vormwood, white atractylodes rhizome, prepared aconite root, dried ginger, honey-fried licorice root and cinnamon, according to the mass ratio of 3:6:1.5:1.5:3:1. The Chinese medicinal composition is prepared through subjecting the Chinese medicinal materials, i.e. the herb of virgate vormwood, the white atractylodes rhizome, the prepared aconite root, the dried ginger, the honey-fried licorice root and the cinnamon to water decoction according to a matching ratio, extracting and concentrating. Proved by the pharmacodynamic tests, the Chinese medicinal composition disclosed by the invention can lower the serum transaminase of hepatic fibrosis model mice, can relieve the degree of the liver collagen deposition of the hepatic fibrosis model mice, can improve the hepatic inflammation and the fibrosis pathological change of the hepatic fibrosis model mice, and has the effect of resisting the pathological change of the hepatic fibrosis, so that the Chinese medicinal composition can be used for preparing a pharmaceutical preparation for resisting the hepatic fibrosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for resisting liver fibrosis, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Liver fibrosis is the common pathological basis for the development of various chronic liver diseases to cirrhosis. Its essence is the imbalance between the synthesis and degradation of intrahepatic extracellular matrix, which leads to a large amount of extracellular matrix, especially collagen, deposited in the liver. The continuous development of liver fibrosis leads to corresponding organ dysfunction and failure, which seriously endangers life and health. Slowing down, preventing or even reversing liver fibrosis is of great significance to reducing the occurrence of serious complications, improving the quality of life of patients and increasing the survival rate. Therefore, the development of anti-hepatic fibro...

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Problems solved by technology

[0003] Liver fibrosis is a dynamic pathological process, including multiple stages of occurrence, development and regression, and each stage has multiple links that affect each other. Therefore, the effect of treating liver fibrosis only for a single link is not ideal

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