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Breviscapine albumin nanoparticles prepared by adsorbing breviscapine through albumin nanoparticles

A technology of albumin nanoparticles and breviscapine, which can be used in respiratory diseases, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as low oral bioavailability, low solubility, and short half-life

Inactive Publication Date: 2012-04-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to literature research, scutellarin has low solubility (water solubility is 20.47±0.26μg / ml), low oral bioavailability (canine oral bioavailability is 0.40±0.19%), and short half-life (canine oral elimination half-life is 79.98±0. 44.50min, the elimination half-life of dog intravenous injection is 55.70±19.09min) and other disadvantages

Method used

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  • Breviscapine albumin nanoparticles prepared by adsorbing breviscapine through albumin nanoparticles
  • Breviscapine albumin nanoparticles prepared by adsorbing breviscapine through albumin nanoparticles
  • Breviscapine albumin nanoparticles prepared by adsorbing breviscapine through albumin nanoparticles

Examples

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Embodiment 1

[0029] 100 parts by volume of albumin nanoparticle suspension (albumin nanoparticle is an 80% ethanol solution, and the concentration of albumin nanoparticle is 3%);

[0030] 250 parts by volume of breviscapine solution (breviscapine concentration is 1.45mg / mL);

[0031] (a) get bovine serum albumin (BSA) and be made into 10% concentration with distilled water, under the stirring condition of 25 ℃, 600r / min, add 4 times of volume 95% ethanol with the speed of 1mL / min, form colloidal solution, Then add 5% glutaraldehyde aqueous solution (0.95 μL per 1 mg of BSA, which can theoretically cross-link 100% of BSA amino groups), and cross-link and solidify at 25° C. for 12 hours on a shaking table.

[0032] (b) Centrifuge the bovine serum albumin nanoparticles (BSA-NPs) solidified in a at a speed of 15000r / min for 15min to remove the organic solvent therein for 3 times, and discard the supernatant after each centrifugation solution, the precipitate was added to its original volume w...

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Abstract

The invention provides breviscapine albumin nanoparticles prepared by adsorbing breviscapine through albumin nanoparticles. The breviscapine albumin nanoparticles comprise the breviscapine serving as an active ingredient and the albumin nanoparticles, and are obtained by adsorbing the prepared and freeze-dried albumin nanoparticles to the breviscapine under a certain condition to carry medicines. Through the breviscapine albumin nanoparticles prepared by adsorbing the breviscapine through the albumin nanoparticles, the problem of low dissolubility of breviscapine aqueous solution is solved; and the breviscapine albumin nanoparticles have obvious slow release characteristic.

Description

technical field [0001] The invention relates to albumin nanoparticles loaded with scutellarin and a preparation method for absorbing scutellarin through albumin nanoparticles, belonging to the technical field of preparations. Background technique [0002] Breviscapine is a flavonoid compound extracted from the natural plant breviscapine, and its main component is scutellarin. Modern pharmacological studies have proved that breviscapine dilates fine arteries, improves heart function and blood supply to the heart and brain; reduces blood viscosity, resists platelets and red blood cell aggregation, and improves red blood cell deformability. Increase tissue perfusion, improve microcirculation and metabolism; scavenge free radicals to prevent tissue reperfusion injury, and reduce white blood cell spontaneous activity. Clinical indications are cerebral thrombosis, cerebral hemorrhage recovery period, coronary heart disease angina pectoris, myocardial infarction, hyperviscosity, a...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/7048A61K47/42A61P3/06A61P7/02A61P9/10A61P11/00A61P13/12A61P35/00
Inventor 高缘席一峰李来存张建军
Owner CHINA PHARM UNIV
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