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2,6-dipicolinic acid-(ferrocene monoformic acid)triphenyltin complex, its preparation method and its application

A technology of dipicolinic acid and triphenyltin, applied in drug combination, antineoplastic drugs, organic chemistry, etc., to achieve high anticancer activity, simple preparation method and high anticancer activity

Inactive Publication Date: 2012-03-28
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the organotin compounds with ferrocene monocarboxylic acid and 2,6-pyridinedicarboxylic acid mixed diacid as ligands and their biological activities have not been reported in the literature.

Method used

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  • 2,6-dipicolinic acid-(ferrocene monoformic acid)triphenyltin complex, its preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: 1.0 mmol FcCOOH (ferrocene monocarboxylic acid), 1.0 mmol NEt 3 (Triethylamine) was dissolved in 15ml of methanol, and then the solution was slowly dropped into 2.0 mmol Ph 3 In the methanol solution of SnCl (triphenyltin chloride), stir at room temperature for 0.5 h, then add 1.0 mmol of 2,6-pyridinedicarboxylic acid dropwise into the above mixed solution, and continue stirring at room temperature for 20 h. Filter and let the filtrate stand at room temperature. After three months, red blocky crystals were obtained, namely organotin compounds 1， The compound yield was 86.5%. The resulting organotin compound ， Through infrared spectrum analysis and X-single crystal diffraction analysis, the results are as follows: IR (KBr, cm -1 ): υ = 2984, 2930 (Cp), 1591, 1474 (COO), 1430 (C=N), 795, 686(Sn-O), 509(Sn-C).

[0018] Crystallographic data: The crystal system of the compound belongs to the monoclinic system, the space group is P2(1) / c, and the unit cell p...

Embodiment 2

[0019] Example 2: 1.0 mmol FcCOOH (ferrocene monocarboxylic acid), 1.5 mmol NEt 3 (Triethylamine) was dissolved in 15ml of methanol, and then the solution was slowly dropped into 2.0 mmol Ph 3 In the methanol solution of SnCl (triphenyltin chloride), stir at room temperature for 0.5 h, then add 1.0 mmol of 2,6-pyridinedicarboxylic acid dropwise into the above mixed solution, and continue stirring at room temperature for 21 h. Filter and let the filtrate stand at room temperature. After three months, red blocky crystals were obtained, and the yield of the compound was 87.3%.

Embodiment 3

[0020] Example 3: 1.0 mmol FcCOOH (ferrocene monocarboxylic acid), 2.0 mmol NEt 3 (Triethylamine) was dissolved in 15ml of methanol, and then the solution was slowly dropped into 2.0 mmol Ph 3 In the methanol solution of SnCl (triphenyltin chloride), after stirring at room temperature for 0.5 h, 1.0 mmol of 2,6-pyridinedicarboxylic acid was added dropwise to the above mixed solution, and continued to stir at room temperature for 22 h. Filter and let the filtrate stand at room temperature. After three months, red blocky crystals were obtained, and the yield of the compound was 86.2%.

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Abstract

The invention discloses a 2,6-dipicolinic acid-(ferrocene monoformic acid)triphenyltin complex, its preparation method and its application. The complex of the invention has high anticancer activity, and can be used as a raw material for preparing a medicine to treat mouse chronic granulocytic leukemia and human cervical carcinoma. Compared with current platinum anticancer medicines, the organotincomplex of the present invention has the characteristics of high anticancer activity, good fat solubility, low cost, simple preparation method and the like.

Description

technical field [0001] The invention relates to a 2,6-pyridinedicarboxylic acid-(ferrocene monocarboxylic acid) triphenyltin coordination polymer, a preparation method thereof, and an application of the compound in anticancer drugs. Background technique [0002] Since the first report by Lockhart et al. (CH 3 ) 2 Sn(O 2 CCH 3 ) 2 Since the crystal structure of organotin carboxylate complexes has been widely used in medicine, catalysis, organic synthesis, marine coatings, wood preservation and PVC plastic heat stabilizers, many chemists have been interested in the structure of such complexes. Relationships between unique properties generate intense interest. In the 1980s, through the research and screening of metal anticancer drugs, Crowe et al. found that certain organotin compounds had higher antitumor activity than cisplatin, which greatly promoted the research on the relationship between the structure and properties of organotin compounds. . The development and app...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F19/00A61P35/02A61P35/00
Inventor 李媛媛李大成窦建民
Owner LIAOCHENG UNIV
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