Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition for treating rheumatoid arthritis and preparation method and application thereof

A rheumatoid and composition technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., and can solve the problem of large dosage

Active Publication Date: 2012-03-21
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF6 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Most of the prescriptions have more medicinal flavors and a large dosage
[0009] At present, there are no reports on the compatible use of Tripterygium wilfordii, Qingfengteng, Chuanshanlong, licorice and related preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for treating rheumatoid arthritis and preparation method and application thereof
  • Medicinal composition for treating rheumatoid arthritis and preparation method and application thereof
  • Medicinal composition for treating rheumatoid arthritis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0082] Get 24g of Tripterygium wilfordii, 18g of Qingfengteng, 18g of Rhizoma chinensis, 12g of Radix Glycyrrhizae, grind into coarse powder, reflux extract twice with 80% ethanol, each time 2 hours, filter, combine filtrate, reclaim ethanol, concentrate into liquid extract ( ρ=1.05~1.10); add 60% ethanol and make into 240ml, after mixing, leave standstill, filter, obtain pharmaceutical composition tincture of the present invention.

Embodiment 2

[0083] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0084] Take 24g of Tripterygium wilfordii, 18g of Qingfengteng, 18g of Chuanshanlong, and 12g of licorice. The above four flavors, Tripterygium wilfordii, Qingfengteng, Chuanshanlong, and licorice are crushed into coarse powder; reflux and extract twice with 70% ethanol for 1.5 hours each time, filter, combine the filtrates, recover ethanol, and concentrate until no alcohol smell Add water to a concentration of crude drug 0.4g / ml, add D101 macroporous adsorption resin (36g), the adsorption flow rate is 2BV / h, first wash with 5 times the amount of water, then use 8 times the amount of 50% ethanol to elute. The flow rate was 2BV / h, the eluate was collected, ethanol was recovered, and dried to obtain 3.02g of purified powder.

[0085]Put 2.5g of glyceryl monostearate, 1.0g of paraffin, 9.0g of liquid paraffin, 800.1g of Span-800.1g, and 0.01g of ethylparaben in a dry beaker, heat to 70-8...

Embodiment 3

[0086] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0087] Take 24g of Tripterygium wilfordii, 18g of Qingfengteng, 18g of Chuanshanlong, 12g of licorice, the above four flavors, tripterygium wilfordii, Qingfengteng, Chuanshanlong and licorice are crushed into coarse powder; reflux extraction twice with 70% ethanol 8 times, each time 1.5 Hour, filter, merge filtrate, reclaim ethanol, after concentrating, make dry extract powder 8g; Get 4g dry extract powder and carry out the preparation of cataplasm, preparation method is as follows:

[0088] Sodium polyacrylate (NP700) 1.8g and carboxymethylcellulose sodium CMC-Na 0.3g are physically mixed and dispersed in part of glycerin 6g, and then poured into 12ml of water mixed with 1g of kaolin to swell under stirring conditions. Phase A: Dissolve 0.1g of polyvinyl alcohol (PVA-124) in 4ml of water at 80°C, transfer to a water bath at 45°C, add 0.1g of gelatin to dissolve, and form phase B; use ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicinal composition for treating rheumatoid arthritis. The medicinal composition is a preparation prepared from the following Chinese herbal medicines in part by weight: 16.8 to 31.2 parts of common threewingnut root, 12.6 to 23.4 parts of ovientvine, 12.6 to 23.4 parts of Ningpo yam rhizome and 8.4 to 15.6 parts of liquoric root. The invention also discloses application of the medicinal composition, and a cataplasm and a preparation method thereof. The medicinal composition has an obvious treatment effect on rheumatoid arthritis; meanwhile, the toxic and side effects of the common threewingnut root are effectively reduced, medication safety is improved, and a safer and more reliable new choice is provided for clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, a preparation method and application thereof. Background technique [0002] Rheumatoid arthritis, also known as rheumatoid (RA), is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, belonging to autoimmune inflammatory disease. Although modern medicine has carried out in-depth research on the pathogenesis and treatment of RA, and achieved certain results, there is still a lack of ideal drugs for treatment, while traditional Chinese medicine has shown a good trend in the treatment of RA. The therapeutic effect of rheumatoid arthritis has attracted extensive attention. [0003] Rheumatoid arthritis is also called Gubi in traditional Chinese medicine. The so-called Gubi in Chinese medicine traditionally refers to joint pain and heaviness of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8945A61K9/70A61P19/02A61P29/00
Inventor 陈立典阮时宝褚克丹徐伟李煌
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com