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Antimicrobial peptide preparation for mucosal tissues

A technology of antimicrobial peptides and preparations, which is applied in the field of carbomer resin and antimicrobial peptide preparations, can solve the problems of great influence on the working environment, achieve the effect of increasing the scope of application, not easy to produce, and not easy to drug resistance

Active Publication Date: 2012-02-29
RISE TECHNOLOGY CO LTD (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while expanding its scope of application, its corresponding working environment will also have a great impact on it.

Method used

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  • Antimicrobial peptide preparation for mucosal tissues
  • Antimicrobial peptide preparation for mucosal tissues
  • Antimicrobial peptide preparation for mucosal tissues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Selection of Antimicrobial Peptides

[0067] The antimicrobial peptides used in the present invention and their nomenclature are shown in Table 1, and each amino acid is represented by three letters.

[0068] The selected antimicrobial peptide name and amino acid sequence of table 1 present invention

[0069] name amino acid sequence serial number Sequence No. 1 Lys Trp His Arg Trp Lys Val Lys Arg Leu Ala Ala Lys SEQ ID: NO.1

Embodiment 2

[0071] Composition of main additives in new formulations of antimicrobial peptide drugs for mucosal tissues

[0072] Other additives of the present invention are shown in following table 2, comprise ethylenediaminetetraacetic acid disodium (EDTA disodium), because it has the function of chelating metal, can be used as preservative of the present invention; Sorbitol (sorbitol) then has moisturizing In addition to sorbitol, the moisturizing agent of the present invention can also be replaced by other moisturizing agents with similar effects such as hyaluronic acid, so as to maintain the moistening of the medicament to facilitate the combination of the medicament and the affected part, and promote the healing of ulcer wounds after infection , and help to improve the comfort of the patient's affected area; the isotonic buffer solution provides an appropriate pH buffer zone, and its appropriate concentration also provides an osmotic pressure corresponding to the organism, which help...

Embodiment 3

[0077] Adjustment of pH value and concentration of Carbopol 980 NF

[0078] (A)pH value

[0079] An appropriate pH value can provide an appropriate substrate environment for antimicrobial peptides, which is helpful for the correct folding of the peptides. Carbopol resin can be used as a base agent related to dosage forms. In order to provide a suitable working environment for peptides, it is necessary to adjust the resin to a suitable pH value range, and its concentration must also be taken into account. The best embodiment obtained so far is that adding 3.2 grams of sodium hydroxide per 10 grams of kappa resin can adjust the pH value to pH 6.0. Table 3 shows the dosage of kappa gel resin preparation.

[0080] Table 3 Dosage of Kappa Resin Formulation

[0081] 1% Carbopol 980 NF added to the ratio of NaOH 0.25％ 0.30％ 0.35％ 0.40％ pH value 5 5.6 6 6.7

[0082] (B) Concentration

[0083] The concentration of kabber wave resin determine...

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Abstract

The invention provides an antimicrobial peptide preparation for mucosal tissues. The antimicrobial peptide preparation comprises an effective amount of antibacterial peptide of which the sequence is SEQIDNO.1, preservative, humectant and isltonic buffer solution, and optionally comprises carbopol. Compared with the conventional antibiotics, the antimicrobial peptide preparation has the advantagesthat the preparation has quick response, residues are avoided, medicine resistance is hardly generated, and biological activity spectra are varied and the like.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, more particularly, the present invention relates to antimicrobial peptide preparations for mucosal tissue comprising antimicrobial peptides, preservatives, humectants, isotonic buffer solutions, and optionally kappa wave resin. Background technique [0002] At present, the abuse of antibiotics and the ravages of viral diseases make human health and aquaculture face more and more challenges. The extensive use of antibiotics, on the one hand, seriously threatens the health of humans and animals due to the residues of antibiotics in food. There are more and more drug-resistant bacteria in the body, which causes a vicious circle, resulting in the continuous decline of the autoimmunity of humans and animals. At present, in developed countries, the amount and type of antibiotics added to feed have been strictly regulated. Europe has banned the addition of antibiotics in feed as earl...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K47/32A61P1/00A61P1/02A61P15/02A61P31/00A61P31/04A61P31/10A61P31/12
Inventor 程家维周箭威
Owner RISE TECHNOLOGY CO LTD (BEIJING)
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