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Method for preparing D-arabinose

A technology of arabinose and sugar liquid, applied in the field of functional sugar, can solve the problems of high production cost, complicated process, low yield of D-arabinose, etc., and achieve the effect of reducing production cost and simple steps

Inactive Publication Date: 2012-02-15
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing D-arabinose, so as to solve the problems of complex processes in the prior art, expensive intermediate raw materials, low yield of D-arabinose, and high production costs.

Method used

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  • Method for preparing D-arabinose

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Effect test

Embodiment 1

[0018] (1) Preparation of D-arabinose solution

[0019] Raw material formula adopts weight percentage, and 150 grams of calcium gluconate are dissolved in water, and concentration is 5%, and ferric sulfate is added as catalyst, and the consumption of catalyst is 1.5% of calcium gluconate quality, while stirring, slowly add hydrogen peroxide, peroxidation in hydrogen peroxide The hydrogen concentration was 30%, the reaction temperature was 71°C, the addition rate of hydrogen peroxide was 30 mL / h, and the equivalent of hydrogen peroxide was 6 times that of calcium gluconate.

[0020] (2) Refining of D-arabinose solution

[0021] The D-arabinose solution prepared in step (1) is filtered to remove the insoluble matter produced by the reaction. The insoluble matter is slightly soluble in water, and sodium carbonate is added to the insoluble matter solution to produce a white precipitate, which dissolves in dilute hydrochloric acid and produces a large number of bubbles. Combined w...

Embodiment 2

[0032] The raw material formula adopts weight percentage, and 235 grams of calcium gluconate are dissolved in water, and concentration is 30%, add ferric sulfate as catalyst, the consumption of catalyst is 4.5% of calcium gluconate quality, while stirring, slowly add hydrogen peroxide. The concentration of hydrogen peroxide in hydrogen peroxide was 30%, the reaction temperature was 75°C, the rate of adding hydrogen peroxide was 150 mL / h, and the equivalent of hydrogen peroxide was 10 times that of calcium gluconate. The reacted D-arabinose solution was filtered to remove calcium hydroxide. At 80°C, slowly add 30% sulfuric acid solution to the sugar solution, stir slowly, and precipitate occurs, then filter. The sugar solution passes through the ion exchange resin. At a temperature of 75°C, concentrate in vacuo to a solid content of 43%. After chromatographic separation, the D-arabinose sugar liquid component and miscellaneous sugar components are obtained. Among them, the D...

Embodiment 3

[0034] The raw material formula adopts weight percentage, and 400 grams of calcium gluconate is dissolved in water, and concentration is 20%, and ferric sulfate is added as catalyst, and the consumption of catalyst is 3% of calcium gluconate mass, and hydrogen peroxide is slowly added while stirring. The concentration of hydrogen peroxide in hydrogen peroxide was 30%, the reaction temperature was 75°C, the rate of adding hydrogen peroxide was 100 mL / h, and the equivalent of hydrogen peroxide was 7 times that of calcium gluconate. The reacted D-arabinose solution was filtered to remove calcium hydroxide. At 80°C, slowly add 20% sulfuric acid solution to the sugar solution, stir slowly, and precipitate occurs, then filter. The sugar solution passes through the ion exchange resin. At 75°C, concentrate in vacuo to a solid content of 45%. After chromatographic separation, the D-arabinose sugar liquid component and miscellaneous sugar components are obtained. Among them, the D-ar...

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Abstract

The invention relates to a method for preparing D-arabinose, and belongs to the technical field of functional sugar. In the method, hydrogen peroxide is controllably added to convert calcium gluconate serving as a raw material into the D-arabinose in the presence of iron sulfate serving as a catalyst; D-arabinose liquid obtained through reaction is subjected to subsequent treatment processes of precipitation reaction, filtration, decolorization, ion exchange and chromatographic separation to form D-arabinose liquid with the purity of over 85 percent; and the D-arabinose liquid is subjected to evaporation concentration and natural cooling crystallization to form D-arabinose crystals. The method comprises the following process steps of: (1) preparing the D-arabinose liquid; (2) refining the D-arabinose liquid; and (3) crystallizing to obtain the D-arabinose crystals with the purity of 96 to 99.9 percent. The calcium gluconate is converted into the D-arabinose, and the steps are simple; and relatively cheap iron sulfate is used as the catalyst, so that the production cost of the D-arabinose is reduced, and the yield of the D-arabinose is improved.

Description

technical field [0001] The invention belongs to the technical field of functional sugars, and relates to a method for producing D-arabinose by using calcium gluconate as a raw material. Background technique [0002] D-arabinose is widely used in the fields of food and biomedicine. D-arabinose, or its oxidized D-arabinonic acid, can be used to produce riboflavin. D-arabinose is also an intermediate in the production of the anticancer drug cytarabine. These uses are limited by the high price of arabinose due to the lack of a low-cost, economical process for the production of D-arabinose. There are various methods of producing D-arabinose. [0003] British patent 953012, a patent applied by Sankyo Company, introduces a process for preparing D-arabinose by total synthesis. This method needs to prepare five intermediate reaction products, so the process is too tedious in terms of industrialization. [0004] Another method is the well-known RUFF method. In the presence of iro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00
Inventor 黄伟红孙鲁周娟杜瑞锋张亮
Owner FUTASTE PHARM CO LTD
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