Application of thaspine derivative HMQ1611 in inhibition of mammary cancer

A technology of tospinine and derivatives, applied in the field of compound pharmacology and molecular biology, can solve the problem that breast cancer cannot be really inhibited

Inactive Publication Date: 2012-02-15
XI AN JIAOTONG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Endogenous estrogen plays a major role in the occurrence of breast cancer, so estrogen receptor (ER) blockers have targeted therapeutic significance. In addition, epidermal growth factor receptor (EGFR) and ErbB2 (HER-2 / neu) is also an important part of the most deeply studied growth factor receptor system in the field of breast cancer, but so far none of these can really play a role in inhibiting breast cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of thaspine derivative HMQ1611 in inhibition of mammary cancer
  • Application of thaspine derivative HMQ1611 in inhibition of mammary cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Below in conjunction with embodiment the present invention is described in more detail.

[0014] In the in vivo experiment, the cultured human breast cancer cell line ZR-75-30 was diluted in the medium to make the cell density 2.5×10 7 Each nude mouse was subcutaneously inoculated with 0.2 mL under the fat pad of the second papilla on the right side. After the inoculation, it was reared in a breeding room without special pathogens, and the tumor growth was regularly observed and recorded until the tumor volume was nearly 100mm. 3 When (measure the volume with a vernier caliper, the calculation formula: V=a×b 2 / 2, where a is the long diameter of the tumor, and b is the short diameter of the tumor), the initial tumor volume and initial body weight were recorded, administered in groups, and the in vivo experiment was divided into 6 groups, 6 rats / group, a total of 36 rats.

[0015] Negative control group: 0.5% CMC-Na physiological saline group.

[0016] Tuspinine deriva...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to application of thaspine derivative HMQ1611 in inhibition of mammary cancer. In an integral level, a mammary cancer ZR-75-30 tumor transplantation tumor model is built on the basis of a nude mouse transplantation tumor model, the inhibition effect of the thaspine derivative HMQ1611 on mammary cancer is researched, and then the mammary cancer resistance passageway of the thaspine derivative HMQ1611 is also researched, thus the inhibition effect of the thaspine derivative HMQ1611 on ER (estrogen receptor)-dependent mammary cancer is verified, and the influence of the thaspine derivative HMQ1611 on ER passageway of mammary cancer cells is also verified, thereby showing that the thaspine derivative HMQ1611 can truly inhibit mammary cancer.

Description

technical field [0001] The invention belongs to the field of compound pharmacological action and molecular biology technology, and specifically relates to the application of a tospinine derivative HMQ1611 for inhibiting breast cancer. Background technique [0002] Breast cancer is a common malignant tumor that threatens the health and life of women all over the world, and its incidence rate ranks first among urban female tumors in my country. Epidemiological data show that with the development of society, the incidence of breast cancer will continue to increase. The development of new anti-mammary tumor drugs will be one of the important means for humans to overcome breast tumors. In recent years, with the development of immunology and molecular biology, people have a more in-depth understanding of the receptors, genes and signal transduction in the process of tumor formation, and the targeted therapy developed on this basis has achieved breakthrough results. Progress, res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/366A61P35/00A61P15/14
Inventor 贺浪冲展颖转张杰张彦民陈寅南王楠刘翠翠李西玲
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap