Maternal inheritance of acquired character -phenotype of acquired character test animal model test method

Abstract

The invention discloses a maternal inheritance of acquired character -phenotype of acquired character test animal model test method and relates to the fields of life science and medicines. The invention provides a test animal model method capable of breeding-cultivating higher mammals with spontaneous diseases applied to simulating human diseases. The descendant test animals with metabolic syndrome-hyperglycemia and diabetes mellitus are obtained by feeding gestational mother animals with high-energy feed and are applied to contrast experiment detection / analysis to obtain a biological energy metabolism regulation and control pathogenesis mechanism and a treatment mechanism of human metabolic syndrome-hyperglycemia, diabetes mellitus, obesity and the like, develop new generation treatment medicines and guide clinical intervention treatment. Existence of 'inheritance of acquired character' is confirmed, so that the conventional modern biological foundation / applied science theory method is overturned fundamentally and completely.

Description

technical field [0001] The invention relates to a maternally acquired trait inheritance-acquired trait phenotype experimental animal model experiment method. It involves the fields of life sciences and medicine. Background technique [0002] Modern preventive-therapeutic medicine—the research and development of existing medicine / drug (vaccine), the development of a new drug that can be approved and successfully marketed, currently requires 1.2 billion US dollars of venture capital and a 12-year trial cycle, of which clinical trials account for about 70% of venture capital. , about 80% of the test cycle; the implementation of basic experimental biological research - that is, after the experimental animal model experiments have achieved results, the success rate of new drugs that can pass III III clinical trials and finally obtain approval for clinical application is only 1%; it may even be Lower: Looking back on the application of nerve cell protective drugs in clinical tria...

AI Technical Summary

Problems solved by technology

The fundamental reason is: human stroke (stroke) is not only caused by the involvement of the "criminal blood vessel" in the blood supply area of ​​a certain hemorrhagic area or ischemic area of ​​the brain center, resulting in acute injury and lesion of the brain cell tissue in the blood supply area of ​​the "criminal blood vessel"; Due to complex different biological factors, or mental factors, or physical factors, or genetic factors, or age factors and life aging factors, or environmental factors... or a variety of different comprehensive factors, all the different blood supply vessels in the brain center They are all affected, all of which are caused by a variety of comprehensive factors, slow natural physiological and pathological time and space scales, blood vessels in the blood supply area are all involved in various degrees of insufficient blood supply, so that all brain cells in the blood supply domain, and cells, molecules, and biological life in the blood supply domain blood vessels Metabolic mechanisms / functions, etc., have undergone various physiological and pathological changes-both damage, "criminal blood vessels" in the hemorrhagic area and the blood supply area of ​​the ischemic area are only the most seriously affected blood vessels; human stroke (stroke) ) patients are mostly middle-aged and elderly people. With the increase of age, the life vitality of aging cells decreases, and the blood vessels involved in the brain center are more susceptible to damage, resulting in a sharp increase in the natural incidence of human stroke, and the incidence of death and disability. The level of disability increases sharply, the recurrence rate of stroke (multiple) increases sharply, and the damaged neurological function becomes more and more difficult to be (partially) restored

Therefore, the streptokinase thrombolytic intervention treatment plan implemented in the last century by modern therapeutic medicine is easy to cause damage to the affected blood vessels of all different blood supply domains in the stroke brain center of middle-aged and elderly people, which has led to multi-center evidence-based As confirmed by medical randomized controlled trials, it not only increases the incidence of symptomatic intracranial hemorrhage, but also increases the mortality rate..., the costly multi-center randomized controlled trial of evidence-based medicine failed! The pre-clinical experiments are not rigorous, and the implementation of simplified basic experimental biological research is (not) consistent with the experimental animal model experiments that simulate clinical human disease characteristics-character phenotypes-scientific research "loopholes"-both human factors science A typical example of the inevitable result of mistakes