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Processing principle-based individualized and characteristic quality evaluation method for Gardenia jasminoides Ellis decoction pieces

A quality evaluation and gardenia technology, which is applied in the field of quality evaluation of traditional Chinese medicine gardenia clinical decoction pieces, can solve the problems of restricting gardenia, inability to effectively control the quality of decoction pieces, lack of modern scientific quality evaluation methods, etc., and achieve standard, scientific and reasonable results

Inactive Publication Date: 2012-02-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] "Chinese Pharmacopoeia" (2005 Edition Part One) only stipulates the content standard of geniposide in gardenia medicinal materials under the gardenia item, and the fried gardenia and burnt gardenia contained in it lack modern scientific and exclusive quality evaluation methods. The quality of decoction pieces cannot be effectively controlled, which affects and restricts the production and clinical application of different decoction pieces of Gardenia

Method used

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  • Processing principle-based individualized and characteristic quality evaluation method for Gardenia jasminoides Ellis decoction pieces
  • Processing principle-based individualized and characteristic quality evaluation method for Gardenia jasminoides Ellis decoction pieces
  • Processing principle-based individualized and characteristic quality evaluation method for Gardenia jasminoides Ellis decoction pieces

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The collection of embodiment 1 Gardenia medicinal materials

[0030] According to the resource distribution of gardenia medicinal materials, gardenia is mainly distributed in the provinces south of the Yangtze River in my country. The medicinal materials used in this experiment were purchased from Taihe Yanxi Town, Jiangxi Province, Jinxi Xiugu, Jiangxi Province, Fengshuling, Chun'an, Zhejiang Province, Liuyang, Hunan Province, and Ji'an, Jiangxi Province. There are at least 10 batches of samples from 7 different producing areas, including Yongfeng County, Cangnan County, Zhejiang Province, and Guanling Town, Fuding City, Fujian Province. representative.

Embodiment 2

[0031] Example 2 Reference Substance Extraction, Isolation, Identification and Purification

[0032] Take 50kg of Jiangxi Taihe gardenia fruit coarse powder, extract by percolation with 95% ethanol, collect the percolation liquid, recover ethanol under reduced pressure until it is in the form of extract, and use HP-20 Dakong adsorption resin for rough separation, and then separate the eluent from each part. Separation and purification by silica gel column chromatography and ODS column chromatography. Using chemistry, spectroscopy (IR, 1 H-NMR, 13 C-NMR, 1 H- 1 H COZY, 1 H- 13C COZY, HMBC, MS) and other techniques identified the structures of 18 compounds. Among them, there are 4 diterpene pigment compounds: crocetin (1), crocetin-1 (crocin 1, 2), crocin 2 (crocin 2, 3) and crocetin-3 (crocin 3 , 4); 3 iridoids: geniposide (geniposide, 5), genipin-1-β-gentiobioside (genipin-1-β-gentiobioside, 6) and 6″- p-coumaroylgenipin gentiobioside (6″-O-P-coumaroyl genipingentiob...

Embodiment 3

[0033] Embodiment 3 Preparation of different decoction pieces of Gardenia jasmine

[0034] Processing equipment: DW-2*8.3 belt dryer, rotary frying machine (DY-640, Henan Zhoukou Pharmaceutical Machinery Factory), rotary disc cutting machine (QY1204), SF-500 sealing machine.

[0035] Preparation of Gardenia decoction pieces: According to the processing methods under the relevant items of "Chinese Pharmacopoeia" or "National Standards for Processing Traditional Chinese Medicine", raw gardenia fruits are taken whole or crushed to prepare raw gardenia products, fried yellow products, and fried coke products and fried charcoal products.

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Abstract

Belonging to the technical field of traditional Chinese medicines, the invention provides a processing principle-based individualized and characteristic quality evaluation method for Gardenia jasminoides Ellis decoction pieces. Based on preliminary revealing of the processing principle of Gardenia jasminoides Ellis, the method conducts quality evaluation to different Gardenia jasminoides Ellis decoction pieces through diterpenoid pigment components with obvious changes, an HPLC (high-performance liquid chromatography) standard fingerprint of iridoid glycoside and representative compound content. While enriching, perfecting and distinguishing quality evaluation methods for different Gardenia jasminoides Ellis decoction pieces, the method of the invention provides the basis for standardized production and clinical application of Gardenia jasminoides Ellis decoction pieces, provides a demonstration for establishing individualized and characteristic quality standards for crude and cooked decoction pieces. In addition, the method provided in the invention can also be used in quality control and evaluation of resources, plantation, identification, preparations, and drug effects etc. in connection with Gardenia jasminoides Ellis medicinal materials.

Description

1. Technical field [0001] The present invention belongs to the field of traditional Chinese medicine technology and involves the quality evaluation method of commonly used slices commonly used in Chinese medicine gardenia. This method is based on the research of gardenia fried principles. Second, background technology [0002] Drinking the medicine into medicine, raw and cooked treatment is a distinctive characteristic and advantage of Chinese medicine.The quality of Chinese medicine drinking tablets is directly related to the clinical effect of traditional Chinese medicine.Therefore, the use of modern scientific and technological methods to explore the establishment of scientific, reasonable, objective and practical, and in line with the characteristics of Chinese medicine decoction tablets is a key issue for stabilizing the quality of drinks and ensuring the clinical efficacy of drinks. [0003] Most of the Chinese medicine drinks came by different methods such as frying, steam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744G01N30/86
Inventor 肖永庆张村李丽李文陈红
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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