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Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof

A technology of effective parts and hemp leaves, which is applied in the field of traditional Chinese medicine pharmacy, can solve the problems of unspecified effective components and their content, chemical component types, content differences, weak basic research on medicinal substances, etc., and achieve harvesting, processing and extraction. The effect of simple process, simple method, and easy industrial production

Inactive Publication Date: 2012-01-04
中国人民解放军第四五一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The comprehensive research results show that: there are many research contents about Zushima (stem bark and root bark), the main medicinal ingredients are clear (coumarin and saponin), the preparation technology and pharmacodynamics research are more in-depth, while the research on Zushima leaves It is almost blank, and the basic research on its pharmacodynamic substances is weak. Its effective components and their content are not clear, and there are very few pharmacodynamic experimental studies. difference

Method used

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  • Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof
  • Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof
  • Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation method of effective fractions of Zushi hemp leaves

[0039] 5 kg of Zushi hemp leaves were crushed through a No. 4 sieve (65 mesh), extracted three times with 12 times of 60% ethanol under reflux, each time for 1 hour, combined the extracts, filtered, and the filtrate decompressed (-0.084Mpa) to recover the ethanol, added water Disperse until the crude drug content is 0.3g / ml, centrifuge (4000 rpm), put the supernatant on a LS-300 macroporous adsorption resin column, wash with water first, remove water-soluble impurities, wash until the effluent is nearly colorless, and then use 2.5BV 70% ethanol was eluted, the eluate was decompressed (-0.084Mpa) to recover ethanol, diluted with water to contain crude drug 1.5g / ml, followed by extraction with an equal amount of ethyl acetate for 4 times, combined extracts, decompressed (- 0.084Mpa) to recover the solvent and concentrate to a relative density of 1.20 (80°C), vacuum-dry and pulverize.

Embodiment 2

[0040] Example 2: The preparation method of the effective parts of Zushi hemp leaves

[0041] 5 kg of Zushi hemp leaves were crushed through a No. 4 sieve (65 mesh), soaked in 5 times of 60% ethanol for 36 hours, put into a percolation barrel, and mixed with 3ml min -1 kg -1 The flow rate of percolation is carried out, 12 times of the common solvent is collected, the percolation liquid is collected, the solvent is recovered under reduced pressure (-0.084Mpa), the solvent is dispersed by adding water to contain crude drug 0.3g / ml, centrifuged (4000 rpm), and the supernatant is LS-303 type macroporous adsorption resin column, first wash with water to remove water-soluble impurities, wash until the effluent is nearly colorless, then elute with 2.5BV70% ethanol, and the eluent is decompressed (-0.084Mpa) to recover ethanol, Dilute with water to contain crude drug 1.5g / ml, then extract 4 times with an equal amount of ethyl acetate, combine the extracts, recover the solvent under r...

Embodiment 3

[0042] Example 3: Preparation method of effective fractions of Zushi hemp leaves

[0043] 5 kg of Zushi hemp leaves were crushed through No. 4 sieve (65 mesh), extracted three times with 8 times of ethyl acetate, 2 hours each time, combined the extracts, filtered, and the filtrate was decompressed (-0.084Mpa) to recover the solvent, and added water Disperse until the crude drug content is 0.3g / ml, centrifuge (4000 rpm), put the supernatant on a LS-300 macroporous adsorption resin column, wash with water first, remove water-soluble impurities, wash until the effluent is nearly colorless, and then use 2.5BV was eluted with 70% ethanol, and the eluate was collected. The eluate was decompressed (-0.084Mpa) to recover ethanol and concentrated to a relative density of 1.20 (80°C), vacuum dried, and pulverized to obtain the product.

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Abstract

The invention relates to an effective site group of daphne giraldii nitsche leaf, a preparation method thereof, a medicinal composition containing the effective site group of the daphne giraldii nitsche leaf and application of the effective site group of the daphne giraldii nitsche leaf to the preparation of medicaments for treating diseases such as traumatic injury, arthritis and the like, and belongs to the technical field of pharmaceutics of traditional Chinese medicine. The effective site group of the daphne giraldii nitsche leaf is high in active ingredients and obvious in medicinal effect, medicinal sites do not damage vegetations and environment, the extraction process is easy and convenient, and the operability is high.

Description

technical field [0001] The present invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to effective parts of Zushi hemp leaves, a preparation method thereof, a pharmaceutical composition containing the effective parts of Zushi hemp leaves, and its preparation as a medicine for treating bruises, arthritis and other diseases. the use of. Background technique [0002] Zushima, also known as Zusima and Zushima, is the root bark of Daphnegiraldii Nitsche, D. tangutica Maxim and D. retusa Hemsl of Daphnegiraldii Nitsche. or stem bark. Spicy, bitter, warm in nature, slightly poisonous, has the effects of expelling wind and dampness, relieving pain and dispelling blood stasis, and is mainly used for rheumatic arthralgia, numbness of limbs, headache, stomach pain, bruises and other diseases. There is a folk proverb that "you can't crawl all over the ground without the ancestor's hemp", which also shows that its analgesic effect is deeply...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P19/02A61P29/00A61K127/00
Inventor 康阿龙汤迎爽李伟张娴张琳静张苏蘅
Owner 中国人民解放军第四五一医院
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