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Long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres, and preparation method thereof

The technology of levofloxacin and sustained-release microspheres is applied in the field of long-acting sustained-release wound dressings, and can solve the problems of hemostatic activity, accelerated wound healing, increased workload of medical workers, poor mechanical tensile properties, etc., and achieves good killing function, The effect of improving bioavailability and good moisture permeability

Inactive Publication Date: 2012-01-04
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan is a polymer obtained by alkaline deacetylation of chitin, which has good biocompatibility, degradability, hemostatic activity and accelerated wound healing, but the mechanical properties of wound dressings prepared solely from chitosan Poor tensile properties limit its application field, (Sakurai T, Nimura Y. Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic [J]. J Biomed Mater Res Part A, 2003, 64: 47 -52) Therefore, other fibers can be added to improve its mechanical strength and tensile properties
[0004] Usually, wound dressings have the function of sucking out wound exudate, keeping the physiological environment of the wound moist, reducing scar formation, reducing wound microorganisms to prevent infection, but there are still defects in effectively controlling wound infection for a long time, which has led to frequent dressing changes Or excise the infected skin, which brings great pain to the patient, and also increases the workload of the medical workers

Method used

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  • Long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres, and preparation method thereof
  • Long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres, and preparation method thereof
  • Long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one: preparation and particle size analysis of levofloxacin microspheres

[0033] Under the temperature condition of 25℃, at 1500r·min -1 50ml of liquid paraffin, 2ml of Span80 and 4ml of n-butanol are mixed and stirred evenly at a rotating speed to form an oil phase; 60mg of levofloxacin and 30mg of chitosan with a molecular weight of 98000 are mixed and added to 10ml of 1% acetic acid aqueous solution to form an aqueous phase; 50ml of phase and 10ml of water phase were emulsified and dispersed for 30 minutes; 29ml of glutaraldehyde was cross-linked and solidified with chitosan, and finally washed and dehydrated with excess petroleum ether and absolute ethanol in turn, and freeze-dried to obtain levofloxacin sustained-release microspheres;

[0034] Another chitosan with a molecular weight of 100,000 was taken, and 28 ml of glutaraldehyde was cross-linked and solidified with the chitosan. The dosage and operation steps of the remaining reagents were the same ...

Embodiment 2

[0036] Example 2: Preparation of long-acting sustained-release wound dressing

[0037] Take an appropriate amount of microspheres and disperse them in purified water by ultrasonic waves to prepare a concentration of 0.104 mg·ml -1 of the suspension. The composite medical non-woven fabric cut into 3cm*4cm is immersed in the above suspension, and the water bath is 50r min at 37°C -1 Shake for 1h, dry in vacuum at 60°C for 4h, vacuum pack in aluminum foil, Co 60 25KGy sterilization, finally made a long-acting slow-release wound dressing containing levofloxacin microspheres, its TEM electron microscope photo is as follows figure 2 As shown, its release curve is as image 3 shown.

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Abstract

The invention discloses a long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres. According to the preparation method of the wound dressing, levofloxacin sustained-release microspheres with grain diameter between 10 and 20mu m are fixed in a composite medical non-woven fabric which mainly comprises chitosan fiber, alginate fiber, viscose fiber, and hydrophobic ethylene propylene fiber; and the long-acting sustained-release wound dressing is prepared by taking the levofloxacin sustained-release microspheres as a medicinal component. In a use process, the medicament quickly release levofloxacin after contacting the blood, tissues and surrounding skin of the wound, and can continuously release levofloxacin for a long time, and the effective release of levofloxacin accumulatively reaches 168h. The long-acting sustained-release wound dressing is applied to treatment of bacterium infection of burnt and scalded skin, and the microsphere state medicament can remarkably improve the bioavailability of effective components of the medicament; and the long-acting sustained-release wound dressing has excellent moisture penetrability, hygroscopicity, mechanical tensile property and biocompatibility, the frequency of dressing change can be reduced, and the curative effect and administration safety cam be enhanced.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a long-acting slow-release wound dressing containing levofloxacin slow-release microspheres. Background technique [0002] Levofloxacin is currently one of the most widely used antibacterial drugs in China. However, its own toxicity and increasing drug resistance greatly limit its further application. Studies have shown that the resistance of bacteria to levofloxacin is related to the intensity of the drug, the interval of the drug and the cycle of the drug. Levofloxacin is prepared in the form of sustained-release microspheres, which can maintain effective blood drug concentration on the wound surface by slowly releasing the drug for a long time, so as to achieve the purpose of sterilization and reduce drug resistance; chitosan can effectively increase the penetration of levofloxacin, Improve its stability and bioavailability, reduce toxic and side effects. (Henry A. Okeri, Ikhuoria M. Arhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/5383A61L15/44A61P31/04
Inventor 黄姝杰关静李志宏武继民张西正程鹏董丽芝李卫红
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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