Medicinal composition for treating mycotic infection at superficial part and application thereof

Abstract

The invention discloses a medicinal composition for treating mycotic infection at the superficial part and application thereof. The medicinal composition comprises miconazole and hanfangchin A, wherein the concentration of the hanfangchin A in a miconazole and hanfangchin A combined system is more than or equal to 40mug / ml. The medicinal composition can be used for an active component for preparing a medicament for treating the mycotic infection at the superficial part. After being verified by an in-vitro antimicrobial test, the hanfangchin A can be used for enhancing the antimycotic effect of the miconazole on dermatophyte and monilial to different degrees, in particular bacteriostasis effect on medicament-resistant fungi; and meanwhile, the dosage of the miconazole is reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating superficial fungal infection and its application. Background technique [0002] Superficial fungal infection is a group of fungal infectious diseases caused by pathogenic fungi infecting human mucous membranes, skin and their appendages such as nails and hair. It is a very common fungal infectious disease in the population, and its incidence has been increasing in recent years. , Seriously affecting people's physical and mental health, quality of life and beauty needs. The incidence of superficial fungal infections has obvious population distribution characteristics. For example, tinea capitis mainly occurs in children, onychomycosis mainly occurs in the elderly or malnourished patients, tinea corporis and tinea manus and pedis mainly occur in young adults, and candida infection of the mucosa It is mainly seen in the vulva and vagina of women and the oral mucosa of immunocompromised pa...

AI Technical Summary

Problems solved by technology

[0003] Miconazole belongs to imidazole antifungal drugs, and is currently the main drug used for the treatment of superficial fungal infections. Bacterial infections; although widely used, the clinical efficacy is not very good, recurrent vulvovaginal candidiasis and tinea manuum are still very common superficial fungal infections

Moreover, due to the increasing number of drug-resistant strains, or the reduction of sensitivity to drugs due to the formation of biofilms of Candida infecting the oral cavity, and the impairment of immune function caused by patients with HIV infection, abuse of antibiotics and glucocorticoids, etc., shallow Local fungal infection not only has a high prevalence rate, but also has a high recurrence rate

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