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A kind of total extract of Scallops and its use in the preparation of medicines for treating hepatitis or protecting liver

A technology of extract and scallion, which is applied to the total extract of scallion and its preparation in the field of treating hepatitis or hepatoprotective medicine, and can solve the problems such as no report and description of the total extract of saffron, elaboration of the pharmacological action of the total extract and the like.

Inactive Publication Date: 2011-12-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Li Quanmiao, Wang Guangshu and others studied the extraction, separation and structural identification of flavonoid glycosides in Saffron onion [J]; Journal of Jilin University (Medical Edition); Issue 01, 2010), but did not further elaborate on the pharmacological effects of the total extract of its effective parts
In addition, in other related documents, there is no report and description on the treatment of hepatitis and hepatoprotective effects of the total extract of Scutellaria japonicus

Method used

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  • A kind of total extract of Scallops and its use in the preparation of medicines for treating hepatitis or protecting liver
  • A kind of total extract of Scallops and its use in the preparation of medicines for treating hepatitis or protecting liver
  • A kind of total extract of Scallops and its use in the preparation of medicines for treating hepatitis or protecting liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of the total extract of Sophora japonica

[0035] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet pack the column, and elute with 95% alcohol until the eluent is mixed with distilled water (1:5) and does not appear turbid. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry at room temperature.

[0036] The whole scallion herb is crushed into powder and extracted with 50% ethanol to obtain the scallion ethanol extract. Put the pretreated macroporous resin column on the ethanol extract of scallion, rinse the water-soluble impurities such as protein and polysaccharide with distilled water, and then eluted with 70% ethanol aqueous solution, collect and concentrate the dried eluate to a powder form, Total extract.

Embodiment 2

[0037] Example 2: Preparation of the total extract of Sophora japonica

[0038] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet pack the column, and elute with 95% alcohol until the eluent is mixed with distilled water (1:5) and does not appear turbid. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry at room temperature.

[0039] The whole scallion herb is crushed into powder and extracted with 70% ethanol to obtain the scallion ethanol extract. Disperse the extract in water and extract with ether. After evaporating the ether from the water layer, apply the scallion ethanol extract on the pretreated macroporous resin column. First rinse the water-soluble impurities such as protein and polysaccharide with distilled water, and then use 30% Elute with ethanol aqueous solution, collect the eluate and concentrate and dry to powder to obtain the total extract.

Embodiment 3

[0040] Example 3: Preparation of the total extract of Sophora japonica

[0041] Take a certain amount of macroporous resin, soak it in 95% ethanol for 24 hours, wet pack the column, and elute with 95% alcohol until the eluent is mixed with distilled water (1:5) and does not appear turbid. Wash away the ethanol with distilled water, pour out the macroporous resin, and dry at room temperature.

[0042] The whole scallion herb is pulverized into powder and extracted with 95% ethanol to obtain the scallion ethanol extract. Disperse the extract in water and extract with petroleum ether. After evaporating the ether from the water layer, apply the scallion ethanol extract on the pretreated macroporous resin column. First rinse the water-soluble impurities such as protein and polysaccharide with distilled water, and then use 95% The eluate is eluted with an aqueous ethanol solution, and the eluate is collected and concentrated and dried to powder to obtain the total extract.

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Abstract

The invention discloses a scorzonera total extract and application thereof to the preparation of medicaments for treating hepatitis or protecting liver. A preparation method for the scorzonera total extract comprises the following steps of: 1) crushing scorzonera whole herbs into powder, extracting by using 30 to 95 percent ethanol, and concentrating to obtain ethanol extractum; 2) loading the ethanol extractum onto a macroporous resin column to perform chromatography; and 3) eluting by using distilled water, eluting the resin column by using 30 to 95 percent of alcohol water solution to obtain eluent, collecting, concentrating and drying the eluent to form powder, namely the scorzonera total extract. The invention also relates to new application of the scorzonera total extract to the preparation of the medicaments for treating the hepatitis or protecting the liver and provides possibility for the preparation and marketing of the two medicaments.

Description

Technical field [0001] The present invention relates to the field of medicines, and in particular to a total extract of Solanum chinensis and its use in preparing medicines for treating hepatitis or protecting liver. Background technique [0002] The liver is the human body’s largest and most complex important metabolic organ. It plays an important role in the metabolism of sugars, lipids, proteins, vitamins, hormones, and bile. At the same time, the liver also plays a role in secretion, excretion, and biotransformation. Function: The liver is also an important shielding organ of the body, and its detoxification function has an important protective effect on the body. Therefore, when liver function is damaged, it will cause metabolic disorders and affect other organ functions. In severe cases, it will be life-threatening. [0003] Hepatitis is one of the diseases that seriously endanger human health. It is mainly caused by a group of pathogens that mainly damage the liver. At pres...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P1/16
Inventor 王广树杨晓虹周小平杨锦竹孙薇陈滴王艳张沐新刘银燕
Owner JILIN UNIV
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