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Degradable fiber-enhanced polycaprolactone degradable bone nail and preparation method thereof through solution method

A technology of polycaprolactone and degradable fiber, which is applied in the fields of medical science and surgery, can solve the problems of low breaking strength and easy fatigue, and achieve the effects of good compatibility, pain relief and simple operation

Inactive Publication Date: 2011-11-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The proposal of calcium phosphate bone cement solves the problem of polymethyl methacrylate. Calcium phosphate bone cement has degradability, good osteoconductivity, biocompatibility, and has been proved to be reasonable as a bone repair material. Calcium phosphate Bone cement can withstand compressive loads, but has low fracture strength, brittleness, and fatigue

Method used

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  • Degradable fiber-enhanced polycaprolactone degradable bone nail and preparation method thereof through solution method
  • Degradable fiber-enhanced polycaprolactone degradable bone nail and preparation method thereof through solution method
  • Degradable fiber-enhanced polycaprolactone degradable bone nail and preparation method thereof through solution method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A polycaprolactone (PCL) degradable bone nail reinforced with degradable fibers, the bone nail is a nail-like object, comprising: degradable fibers and PCL resin; wherein the weight ratio of the degradable fibers in the bone nail It is 20%; the degradable fiber dispersed in the bone nail plays the role of strengthening and toughening, while the PCL resin plays the role of the bone nail matrix.

[0030] The preparation includes: (1) Take some PLA slices and dry them under vacuum at 150°C for 5 hours; then extrude them in a melt spinning machine to obtain PLA primary single fibers; The diameter is 0.05 mm; the fibers are cut into staple fibers with an average length of 8 mm long.

[0031] (2) Weigh 98 g of PCL and 2 g of TBC with a balance, and put PCL and TBC into 50 ml of ethyl acetate for dissolution to obtain a PCL solution.

[0032] (3) Put PLA short fibers into PCL solution, the weight ratio of fiber to PCL is PLA:PCL=10:100, and stir evenly.

[0033] (4) Cast the...

Embodiment 2

[0036] (1) Take a number of PGA slices and dry them under vacuum at 120°C for 6 hours; then extrude them in a melt spinning machine to obtain PGA primary single fibers; after stretching, obtain PGA stretched fibers with a single filament diameter of 0.08 mm; the fibers were cut into staple fibers with an average length of 10 mm long.

[0037] (2) Weigh 98 g of PCL and 2 g of dodecyl methacrylate with a balance, and put PCL and dodecyl methacrylate into 50 ml of ethyl acetate for dissolution to obtain a PCL solution.

[0038] (3) Put the PGA short fiber into the PCL solution, the weight ratio of the fiber to the PCL is PLA:PCL=15:100, and stir evenly.

[0039] (4) Cast the PCL solution mixed with PGA short fibers into a cylindrical mold several times, and vacuumize to remove the solvent; after the casting is completed, put the mold into an oven after the solvent is basically removed, and set it at 45°C for 1 hour Allow the compound to cure.

[0040] (5) Take out the PGA fiber...

Embodiment 3

[0042] (1) Take a number of PGLA slices and dry them under vacuum at 120°C for 6 hours; then extrude them in a melt spinning machine to obtain PGLA primary fiber bundles, each bundle of fibers has 8 single fibers; after stretching, PGLA fibers are obtained. Stretch the fiber bundle, and its single fiber diameter is 0.03mm; Preserve the fiber bundle in the state of long filament bundle.

[0043] (2) Weigh 98 g of PCL and 2 g of myristyl methacrylate with a balance, and put PCL and myristyl methacrylate into 50 ml of ethyl acetate for dissolution to obtain a PCL solution.

[0044] (3) Arrange the PGLA fiber bundles neatly in the mold so that the axial direction of the fiber bundles is parallel to the central axis of the cylindrical mold, and the weight ratio of the fibers to PCL is PGLA:PCL=20:100.

[0045] (4) Cast the PCL solution into a cylindrical mold several times, and remove the solvent by vacuuming; after the casting is completed, the mold is put into an oven after the s...

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Abstract

The invention relates to a degradable fiber-enhanced polycaprolactone degradable bone nail and a preparation method thereof through a solution method. The bone nail is a nail-shaped object and comprises degradable fibers and polycaprolactone resin, wherein the degradable fibers are dispersed in the bone nail. The preparation method comprises the following steps of: (1) drying a high molecular material which can be absorbed by a human body and spinning into nascent fibers in a screw extruder in a molten mode, and drawing to obtain drawn fibers; (2) dissolving the polycaprolactone and an interface cosolvent in acetic ether to prepare a polycaprolactone solution; and (3) casting and pouring the polycaprolactone solution in a mould for a plurality of times, simultaneously adding the drawn fibers and removing the solvent; after the casting is finished, shaping the mould after the solvent is removed; and demoulding and performing lathe processing to obtain the bone nail. The degradable bone nail has high mechanical performance and bioavailability; the problem that the bone nail is required to be taken out through a secondary operation can be completely solved due to the degradability; the pain of a patient can be greatly relieved; the degradation period is adjustable; the preparation method is simple; and the bone nail is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of degradable bone nails, in particular to a polycaprolactone degradable bone nail reinforced with degradable fibers and its solution method preparation. Background technique [0002] According to the latest data, the population aging is accelerating, and the elderly population will experience its first growth peak. The elderly population aged 60 and above will increase from an average annual net increase of 4.8 million in the "Eleventh Five-Year Plan" to about 9 million in the "Twelfth Five-Year Plan", and the total will exceed 200 million in 2015. 【The total population of our country will reach about 1.39 billion by the end of the 12th Five-Year Plan period Zhang Liyun Xinhua News Agency 2010-07-03】. With the advent of an aging society, osteoporosis and other fractures caused by aging and frailty will increase sharply. Jiao Hongwei from the 309 Hospital of the Chinese People's Liberation Army pointed out...

Claims

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Application Information

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IPC IPC(8): A61L31/06
Inventor 杨庆张洪瑞袁增艺郯志清沈新元
Owner DONGHUA UNIV
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