Application of 9-cis-retinoic acid in preparing medicament for treating diabetic skin ulcer

A technology for cis-retinoic acid and skin ulcers, which is applied in the application field of medicines, can solve the problems of intractable diabetes, decreased anti-infection ability, etc., and achieves the effect of improving the area or depth of skin ulcers

Inactive Publication Date: 2011-11-23
天津拓飞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many diabetic foot ulcers are difficult to heal due to blood circulation disturbance and decreased resistance to infection

Method used

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  • Application of 9-cis-retinoic acid in preparing medicament for treating diabetic skin ulcer
  • Application of 9-cis-retinoic acid in preparing medicament for treating diabetic skin ulcer
  • Application of 9-cis-retinoic acid in preparing medicament for treating diabetic skin ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1MDI301 (9-cis retinoic acid) regulates the function of collagen

[0021] Due to insufficient insulin in the body of diabetic patients, it not only inhibits the synthesis of collagen, but also accelerates the decomposition of collagen capsules. Experiments have found that 9-cis retinoic acid (0.025%-0.05%) has a good up-regulation function on collagen I and collagen III, and increases the collagen content in the skin of diabetic patients, thereby effectively inhibiting their ulcers. The regulation of collagen by 9-cis retinoic acid, see Figure 1a , 1b . Example 29 - Regulatory function of cis-retinoic acid on matrix metalloproteinase (MMP)

Embodiment 29

[0022] Matrix metalloproteinase 1 is highly expressed in skin cells of diabetic patients. Experiments have found that 9-cis retinoic acid (0.025%-0.05%) has a good regulatory effect on matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in the skin of diabetic patients, reducing the activity of these matrix metalloproteinases. Express. Such as Figure 2a , 2b shown.

Embodiment 39

[0023] Example 39 - Up-regulation function of cis-retinoic acid on tissue inhibitor of metalloproteinase 1

[0024] Experiments have shown that the expression of tissue inhibitor of metalloproteinase 1 in the skin of diabetic patients is lower than that of normal human skin cells, and 9-cis retinoic acid (0.025%-0.05%) can improve the expression of tissue inhibitor of metalloproteinase 1 positively correlated, such as image 3 shown.

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Abstract

The invention discloses an application of 9-cis-retinoic acid in preparing a medicament for treating diabetic skin ulcer. In experiments, a diabetic mouse model is used, and the mouse is fed until the skin of the mouse is ulcerous or abnormal. Proven by the experiments, the skin ulcer is better improved in area or depth after the mouse is treated by the composition of 0.025%-0.05% of 9-cis-retinoic acid and 0.5%-1% of hydrocortisone in mass percent.

Description

technical field [0001] The invention relates to the field of medicines related to diabetes, in particular to the application of 9-cis retinoic acid in the preparation of medicines for treating diabetic skin ulcers. Background technique [0002] Skin complications, a common complication in people with diabetes, are ulcers that develop from areas of pressure on the foot or ankle and can become progressively more severe, allowing infection or ischemia The situation is more serious. Due to blood circulation disorder and decreased anti-infection ability, many diabetic foot ulcers are difficult to heal. Due to diabetic endarteritis leading to ischemia and an unmanageable bacterial infection, the patient had to amputate the limb. Research shows that half of diabetics lose their other foot within three years of having one foot removed. Therefore, there is an urgent need for a drug that can effectively treat diabetic ulcers, which can save patients with diabetic skin ulcers from t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/203A61P3/10A61P17/02
Inventor 李瑛
Owner 天津拓飞科技有限公司
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