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Rosa davurica total flavone extract, its extracting method and its medical use

An extraction method and a technology of total flavonoids, which are applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of less development and application, and achieve the effect of abundant resources

Inactive Publication Date: 2011-11-02
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Rosa rosea is rich in natural resources and has a wide range of pharmacological activities, but its development and application are less

Method used

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  • Rosa davurica total flavone extract, its extracting method and its medical use
  • Rosa davurica total flavone extract, its extracting method and its medical use
  • Rosa davurica total flavone extract, its extracting method and its medical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] a. Dry and pulverize the Rosa rosea fruit, extract with 6 times the amount of 75% ethanol under heat reflux for 3 times, each time for 5h, 3h, and 1h, filter, and combine the extracts;

[0019] b. Put the extract obtained in step a on a 30-mesh polyamide column, wash it with water until it becomes colorless, then elute with 75% ethanol, collect the eluate, recover the ethanol to obtain an extract, and dry to constant weight.

Embodiment 2

[0021] a. Dry and pulverize the Rosa rosea fruit, extract with 8 times the amount of 70% ethanol under heat reflux for 3 times, each time for 5h, 3h, and 1h, filter, and combine the extracts;

[0022] b. Put the extract obtained in step a on a 45-mesh polyamide column, wash with water until it becomes colorless, then elute with 70% ethanol, collect the eluate, reclaim the ethanol to obtain an extract, and dry to constant weight.

Embodiment 3

[0024] a. Dry and pulverize the Rosa rosea fruit, extract 3 times with 10 times the amount of 65% ethanol under heat reflux, each time for 5h, 3h, 1h, filter, and combine the extracts;

[0025] b. Put the extract obtained in step a on a 60-mesh polyamide column, wash with water until colorless, then elute with 65% ethanol, collect the eluate, recover ethanol to obtain extract, and dry to constant weight.

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Abstract

The invention provides a rosa davurica total flavone extract, its extracting method and its medical use, and relates to a traditional Chinese medicine extract in effective medical parts, an extracting method thereof and the medical use thereof. The invention comprises the following steps: drying and crushing traditional Chinese medicine rosa davurica and performing a heat backflow extraction by 65% to 75% of ethanol, putting an extraction solution into 30 to 60 meshes of polyamide column, washing to colorless and eluting with ethanol of the concentration of 65 to 75 %, collecting an eluent and recovering ethanol to obtain raw material medicines used for the research of new medicines of traditional Chinese medicine. According to the invention, the total flavone content in the extract detected by using an UV spectrophotometry method is more than 50%. The rosa davurica total flavone extract which is extracted and purified by the invention has the functions of treating coronary heart diseases, cardiac muscle ischemia, arrhythmia, hyperlipidemia and the like.

Description

technical field [0001] The invention relates to an extract of a traditional Chinese medicine, an extraction method thereof and a medicinal use thereof. Background technique [0002] Rosa davurica Pall., Rosa davurica Pall., is a deciduous shrub plant belonging to the Rosaceae Rosa, mainly distributed in the northeast of my country. Its fruit is also known as Rosa davurica Pall. Food, made into fruit wine, tea, etc., rose rosy fruit taste slightly sour, warm in nature. Traditional medicine lists rose thorn fruit as a tonic. According to the "Chinese Dictionary": rose thorn fruit has the effects of invigorating the spleen and regulating qi, nourishing blood and regulating menstruation. Modern medical research has found that thorn rose fruit has anti-aging, anti-fatigue, resistance to hypoxia, and enhances the immune function of the human body. Long-term consumption can significantly increase the SOD content in the human body. The pulp is rich in vitamins, and rose fruit is on...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61P3/06A61P9/06A61P9/10A61K131/00
Inventor 钟方丽李平亚王晓林
Owner JILIN INST OF CHEM TECH
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