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Biodegradable poly(butylene adipate/terephthalate) hollow foamed particle and preparation method thereof

A technology of terephthalic acid and polyadipic acid, which is applied in the direction of medical preparations, pharmaceutical formulas, and capsule delivery of non-active ingredients, and can solve problems such as difficult large-scale industrial production, a large amount of organic solvents, and low production efficiency , to achieve the effects of universality, low requirements for production equipment, and low production costs

Active Publication Date: 2011-10-19
浙江博发新材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the shell of the hollow material is made into a foamed material, raw materials can be saved, and the deficiency of the shell performance of the hollow material can be overcome, but there is no report on its preparation method at present.
In addition, most of the current methods for preparing hollow materials are relatively complicated and cumbersome, requiring the use of a large amount of organic solvents, the products require post-processing, low production efficiency, high cost, and difficult to large-scale industrial production

Method used

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  • Biodegradable poly(butylene adipate/terephthalate) hollow foamed particle and preparation method thereof
  • Biodegradable poly(butylene adipate/terephthalate) hollow foamed particle and preparation method thereof
  • Biodegradable poly(butylene adipate/terephthalate) hollow foamed particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] PBAT particles are placed in a high-pressure mold in a molded physical gas foaming device to ensure that the total volume of the particles does not exceed 1 / 25 of the mold volume, so that the particles have enough space for foaming. When the mold reaches the set temperature of 110°C, fill it with 16MPa of CO 2 , kept at constant temperature and pressure for 5-15 minutes, and then released to normal pressure at a speed of 23MPa / s. The foamed material was taken out and subjected to optical microscope analysis and density measurement, the results are shown in Table 1.

[0040] Table 1 Comparison of structural properties of PBAT hollow expanded particles prepared by different holding times

[0041]

Embodiment 2

[0043] PBAT particles are placed in a high-pressure mold in a molded physical gas foaming device to ensure that the total volume of the particles does not exceed 1 / 25 of the mold volume, so that the particles have enough space for foaming. When the mold reaches the set temperature of 100-120°C, fill it with 16MPa of CO 2 , kept at constant temperature and pressure for 15 minutes, and then released to normal pressure at a speed of 23MPa / s. The foamed material was taken out and subjected to optical microscope analysis and density measurement, the results are shown in Table 2.

[0044] Table 2 Comparison of structural properties of PBAT hollow expanded particles prepared at different foaming temperatures

[0045]

Embodiment 3

[0047] PBAT particles are placed in a high-pressure mold in a molded physical gas foaming device to ensure that the total volume of the particles does not exceed 1 / 25 of the mold volume, so that the particles have enough space for foaming. When the mold reaches the set temperature of 120°C, fill it with CO at the set pressure. 2 , kept at constant temperature and pressure for 15 minutes, and then released to normal pressure at a certain speed. The foamed material was taken out and subjected to optical microscope analysis and density measurement, the results are shown in Table 3.

[0048] Table 3 Comparison of structural properties of PBAT hollow expanded particles prepared by different foaming pressures

[0049]

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Abstract

The invention discloses a biodegradable poly(butylene adipate / terephthalate) hollow foamed particle and a preparation method thereof. The preparation method is characterized by comprising the following steps of: carrying out a mould pressing physical gas foaming method on poly(butylene adipate / terephthalate) granules with a melting point of Tm DEG C in the presence of a physical gas foaming agent at the temperature of (Tm-25 DEG C)-(Tm+15 DEG C) and the pressure of 8-20MPa; performing constant temperature pressure preservation for 5-20 minutes; releasing pressure at the speed of 5-30MPa / s, and sampling and cooling within 30 seconds so as to obtain hollow foamed particles with a foamed shell layer and a hollow inside. Because the foamed layer is more beneficial to drug release and filling as compared with a solid and the hollow foamed particle has the biodegradable characteristic, thus the hollow foamed particle has excellent property, and is hopeful to be widely used in the fields of drug controlled release, agricultural fertilizer controlled release, filling material storage and use and the like. The preparation method is convenient, has simple process flow, wide applicable range, short production period and low cost, is environmentally-friendly and is suitable for industrial product; and the hollow foamed particle disclosed by the invention has no solvent and no impurities, and the size of the particle is controllable and adjustable.

Description

Technical field: [0001] The invention relates to a biodegradable polyadipate-terephthalate-butylene glycol (PBAT) hollow foaming particle and a preparation method thereof, belonging to the field of polymer hollow sphere materials or hollow capsules. Background technique: [0002] Polymer hollow material is a polymer material with a special structure, the shell part is polymer, and the interior is hollow air bubbles. This polymer material with special structure has broad application prospects in the fields of food, light industry, medicine, petrochemical industry, agriculture and animal husbandry, and biotechnology. There are various methods for preparing hollow materials reported so far, which can be divided into chemical methods (in-situ polymerization method, interfacial polymerization method, etc.), physical and chemical methods (composite coacervation method, composite emulsion method, etc.) and physical methods ( Air suspension method, spray drying method, etc.), in th...

Claims

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Application Information

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IPC IPC(8): C08L67/02C08J9/12C08J9/14A61K9/50A61K47/34
Inventor 李文光虞晨阳王亚吴炳田
Owner 浙江博发新材料股份有限公司
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