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Completely-biodegraded nanometer starch grafted poly glutamic acid benzyl ester

A technology of polybenzyl glutamate and nano-starch, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems that the synthesis of nano-starch-g-polybenzyl glutamate has not been reported, and achieve Effect of Compatibility Improvement

Inactive Publication Date: 2011-10-19
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report on the synthesis of nano-starch-g-polybenzyl glutamate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of alkynyl-terminated polybenzyl glutamate

[0023] Dissolve 7.5632g of γ-benzyl-L-glutamate-N-carboxylic acid anhydride in 70ml of dioxane, add 4.1084ml of propargylamine monomer, react at room temperature for 72h, settle with 400ml of ether, filter, and After washing three times and vacuum drying for 24 hours, the alkynyl-terminated polyglutamic acid benzyl ester with a molecular weight of 1500 was obtained.

Embodiment 2

[0024] Embodiment 2: Preparation of alkynyl-terminated polybenzyl glutamate

[0025] Dissolve 14.6853g of γ-benzyl-L-glutamate-N-carboxylic acid anhydride in 140ml of dioxane, add 3.9884ml of propargylamine monomer, react at room temperature for 72h, settle with 800ml of ether, filter, and After washing three times, vacuum drying for 24 hours, the alkynyl-terminated polyglutamic acid benzyl ester with a molecular weight of 3000 was obtained.

Embodiment 3

[0026] Embodiment 3: Preparation of alkynyl-terminated polybenzyl glutamate

[0027] Dissolve 10g of γ-benzyl-L-glutamate-N-carboxylic acid anhydride in 100ml of dioxane, add 1.6522ml of propargylamine monomer, react at room temperature for 72h, settle with 700ml of ether, filter, and wash with ether Three times, vacuum-dried for 24 hours to obtain benzyl alkynyl-terminated polyglutamate with a molecular weight of 10,000.

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PUM

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Abstract

The invention provides a preparation method for completely-biodegraded nanometer starch grafted poly glutamic acid benzyl ester. The nanometer starch grafted poly glutamic acid benzyl ester is prepared by taking nanometer starch as raw materials and adopting a click chemistry method. The preparation method comprises the steps of: first, utilizing reaction activity of hydroxyl in the nanometer starch structure, reacting with methanesulfonyl chloride and sodium azide sequentially, and introducing azide group in molecules of nanometer starch; reacting N-carboxylic acid anhydride (BLG-NCA) of glutamic acid benzyl ester with propargylamine monomer, and preparing poly glutamic acid benzyl ester with tribond function as end group; and secondly, utilizing azide function group in the nanometer starch molecule and tribond function group in poly glutamic acid benzyl ester molecule to generate azide-alkynyl Husigen addition reaction to prepare nanometer starch poly glutamic acid benzyl ester grafted copolymer. The copolymer is prepared by the click chemistry method and is characterized in that the reaction has efficiency and controllability, the grafted rate of the poly glutamic acid benzyl ester is clear and controllable, the copolymer has a clear structure, the hydrophilcity of starch and hydrophobicity of poly glutamic acid benzyl ester can be improved, the melting point of the nanometer starch is lowered, and the copolymer materials can be used as fillers, bulking agents and drug carriers.

Description

Technical field: [0001] The invention belongs to the technical field of preparation of fully biodegradable nanometer starch-based graft copolymers. technical background: [0002] Click chemistry, proposed by the American chemist Sharpless, who won the Nobel Prize in Chemistry in 2001, is a new method for rapidly synthesizing a large number of compounds. It places particular emphasis on developing new approaches to chemistry based on the synthesis of carbon-heteroatom bonds (C-X-C). The representative reaction of click chemistry is the copper-catalyzed azide-alkynyl Husigen cycloaddition reaction. Due to the high efficiency and high control of click chemistry, this method has been rapidly developed in many research fields, such as DNA, self-assembly, surface modification, dendrimers, functional polymers, combinatorial chemistry and biomedicine. Application prospects. [0003] Starch is an important renewable and biodegradable natural resource that is widely available and i...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G69/10A61K47/36
Inventor 陈莉单红玲张喆孙静茹庄秀丽陈学思
Owner NORTHEAST NORMAL UNIVERSITY
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