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Product made from rosemary extract for treating alcoholic liver and fatty liver, and processing technology thereof

A technology of rosemary and fat-soluble extracts, which is applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve problems such as ineffective effects, high drug costs, and long courses of treatment, so as to prevent harm to the human body The existence of substances, the guarantee of naturalness, and the effect of improving production efficiency

Inactive Publication Date: 2011-09-28
YUZHOU SENYUAN BENCAO NATURAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, there are a variety of products for the treatment of alcoholic liver and fatty liver, but the current liver disease treatment drugs have the disadvantages of ineffective effect, long course of treatment, and high cost of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0027] (1) Cut rosemary fresh leaves or rosemary fresh branches and leaves into segments larger than 0.25 cm, and use ultrasonic countercurrent extraction, the extraction solvent is 65% edible alcohol, the solid-liquid ratio is 1:25, and the extraction temperature is 65 ° C. Extraction time 30 minutes.

[0028] (2) The extract is filtered through a tubular membrane or a ceramic membrane (the pore size of the membrane is 30nm), and the filtrate is re-filtered through a roll-type membrane and sodium-filtered to obtain interceptions of different molecular weights, and the non-permeate is concentrated under reduced pressure until precipitation or no ethanol smell occurs , solid-liquid separation to obtain solid A and liquid B.

[0029] (3) The solid matter A was spray-dried to obtain the rosemary fat-soluble antioxidant (carnosic acid content 20%-40%). Liquid B, with macroporous resin adsorption, 40, 50, 60, 70, 80% ethanol gradient desorption, the desorption solution is concentr...

Embodiment example 2

[0032] (1) According to the steps (1)(2)(3) in "Example 1", the content of carnosic acid is 20%~40% rosemary fat-soluble antioxidant, and the content of rosmarinic acid is about 50% of water-soluble antioxidants.

[0033] (2) Mix the fat-soluble antioxidant and water-soluble antioxidant in step (1) by 1:1, and dissolve the mixed extract in soybean oil to make soft capsules, which are then treated with aluminum-plastic blister pressing plates and packed into library.

Embodiment example 3

[0035] (1) According to the steps (1)(2)(3) in "Example 1" until the content of carnosic acid is 20%~40% rosemary fat-soluble antioxidant, and the content of rosmarinic acid is about 50% of water-soluble antioxidants.

[0036] (2) Stir the fat-soluble antioxidant and water-soluble antioxidant obtained in step (1) evenly with a mixer at a ratio of 1:1, mix in an appropriate amount of compressible starch to make a soft material, and press it into a 0.25g tablet Cores are coated and then packaged into finished products.

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PUM

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Abstract

The invention relates to a product made from rosemary extract for treating alcoholic livers and fatty livers, and a processing technology of the product. According to the invention, fat-soluble extracts and water-soluble extracts of rosemary are processed through an ultra-low temperature extraction technology in modern biology, and are formulated and combined into finished products. The extracts are prepared through a series of technologies: an ultrasonic countercurrent and membrane separation (molecular sieve) technology, a membrane separation (molecular sieve) technology, and a macroporous resin adsorption technology. With the technologies, high contents of fat-soluble and water-soluble extracts are obtained from rosemary. The product is stable in quality, safe in use, and provides substantial curative effects against alcoholic livers and fatty livers.

Description

Technical field: [0001] The invention belongs to a pure natural solution product derived from plant extracts for treating alcoholic liver and fatty liver, and specially designs a production process for separating and obtaining two kinds of antioxidants from the Lamiaceae plant rosemary. Background technique: [0002] The pathogenesis of fatty liver can basically be divided into the following categories: abnormal fat metabolism, hormone influence, environmental factors, genetic factors, oxygen stress and lipid peroxidation damage, immune response, changes in liver screening, the role of free fatty acids, deficiency Oxygen and hepatic microcirculation disturbance, oxygen stress and lipid peroxidation damage refer to oxygen stress with increased pro-oxidants and decreased anti-oxidants, which can lead to increased production of free radicals or reactive oxygen from molecular oxygen, and reactive Oxygen reacts with polyunsaturated fatty acids to generate lipid peroxidation. [...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61K9/48A61P1/16A61K127/00A61K135/00
Inventor 解克伟张明礼范媛媛
Owner YUZHOU SENYUAN BENCAO NATURAL PRODS
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